The Potential Use of Chromogenic Assays in the Routine Monitoring of Oral Anticoagulant Therapy

  • R. M. Bertina
  • E. A. Loeliger
Part of the Developments in Hematology book series (DIHI, volume 1)

Abstract

The treatment of patients with oral anticoagulants proceeds in two phases. After an initial loading dose of anticoagulant the plasma concentration of the factors VII, IX, X and II decreases each according to its own half life (1–3). This is schematically illustrated in Figure 1. The factor VII activity rapidly disappears from the plasma, while the half life of factor II is about 10 times higher. After this loading dose, anticoagulant administration is gradually decreased until a maintenance dose is reached that result in the desired level of anticoagulation. In these so-called stabilized patients the administrations of the anticoagulant is such that the percentage of inhibition of the synthesis of procoagulant factors VII, II, IX and X is virtually the same for each factor (4).

Keywords

Carboxylate Half Life Thrombin Coumarin Prothrombin 

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Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1980

Authors and Affiliations

  • R. M. Bertina
    • 1
  • E. A. Loeliger
    • 1
  1. 1.Hemostasis and Thrombosis Research Unit, Department of MedicineUniversity Hospital LeidenLeidenThe Netherlands

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