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Relationships between Sodium and Potassium Intake and Blood Pressure

  • Chapter
Epidemiology of Arterial Blood Pressure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 8))

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Abstract

Kempner’s demonstration of the effectiveness of a rice diet in reducing blood pressure in hypertensive individuals initiated a series of experiments that unequivocally established the therapeutic value of severe sodium restriction in lowering the blood pressure in hypertensive individuals [1,2]. Subsequent studies by Murphy [3], Dahl et al. [4, 5], and others [6–8] provided documentation that this decrease in blood pressure was associated with a decrease in total body sodium as indicated by a negative sodium balance. The magnitude of the blood pressure drop could be quantitatively linked with the magnitude of sodium loss in these studies, thereby establishing a clear association between total body salt content and blood pressure. A number of population studies beginning with the observations of Dahl [9–11], and representing sampling from different geographic regions, have shown that those populations with a high sodium intake have a higher point prevalence of essential hypertension and populations with very low sodium intakes exhibit virtually no elevation of blood pressure.

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References

  1. Kempner W: Treatment of kidney disease and hypertensive vascular disease with rice diet. NC Med J 5:125, 1944.

    Google Scholar 

  2. Kempner W: Treatment of hypertensive vascular disease with rice diet. Am J Med 4:454, 1948.

    Article  Google Scholar 

  3. Murphy RJF: The effect of ‘rice diet’ on plasma volume and extracellular fluid space in hypertensive subjects. J Clin Invest 29:912, 1950.

    Article  PubMed  CAS  Google Scholar 

  4. Dahl LK, Love RA: Evidence for relationship between sodium chloride intake and human essential hypertension. AMA Arch Intern Med 94:525, 1954.

    PubMed  CAS  Google Scholar 

  5. Dahl LK, Love RA: Etiologic role of sodium chloride intake in essential hypertension in humans. JAMA 164:397, 1957.

    CAS  Google Scholar 

  6. Dole VP, Dahl LK, Cotzias GC, Eder HA, Krebs ME: Dietary treatment of hypertension: Clinical and metabolic studies on patients on rice-fruit diet. J Clin Invest 29:1189, 1950.

    Article  PubMed  CAS  Google Scholar 

  7. Dustan HP, Cumming GR, Corcoran AC, Page IH: A mechanism of chlorothia-zide enchanced effectiveness of antihypertensive ganglioplegic drugs. Circulation 19:360, 1959.

    PubMed  CAS  Google Scholar 

  8. Wilson IN, Freis ED: Relationship between plasma and extracellular fluid volume depletion and the antihypertensive effect of chlorothiazide. Circulation 20:1028, 1959.

    PubMed  CAS  Google Scholar 

  9. Dahl LK, Love RA: Evidence for relationship between sodium (chloride) intake and essential hypertension. AMA Arch Intern Med 94:525, 1954.

    PubMed  CAS  Google Scholar 

  10. Page LB, Damon A, Moellering RC: Antecedents of cardiovascular disease in six Solomon Island Societies. Circulation 49:1132, 1974.

    PubMed  CAS  Google Scholar 

  11. Page LB: Epidemiological evidence on the etiology of human hypertension and its possible prevention. Am Heart J 91:527, 1976.

    Article  PubMed  CAS  Google Scholar 

  12. Sasaki N: The relationship of salt intake to hypertension in the Japanese. Geriatrics 19:735, 1964.

    PubMed  CAS  Google Scholar 

  13. Prior IAM, Evans JG, Harvey HPB, Davidson F, Lindsay M: Sodium intake and blood pressure in two Polynesian populations. N Engl J Med 279:515, 1968.

    Article  PubMed  CAS  Google Scholar 

  14. Dahl LK, Silver L, Christie RW and Genest J: Adrenocortical function after prolonged salt restriction in hypertension. Nature 185:110, 1960.

    Article  PubMed  CAS  Google Scholar 

  15. Hamilton M, Pickering GW, Roberts JAF, Sowry GSC: The aetiology of essential hypertension. Part 2: Scores for arterial blood pressure adjusted for differences in age and sex. Clin Sci 13:37, 1954. Part 4: Role of inheritance. Clin Sci 13:273, 1954.

    PubMed  CAS  Google Scholar 

  16. Ambard L, Beaujard E: Causes de l’hypertension arterielle. Arch Gen Med 1:520, 1904.

    Google Scholar 

  17. Allen FM: Arterial hypertension. JAMA 74:652, 1920.

    Google Scholar 

  18. Allen FM: Treatment of arterial hypertension. Med Clin North Am 6:475, 1922.

    Google Scholar 

  19. Dahl LK: Medical progress. Salt intake and salt need. N Engl J Med 258:1152, 1205, 1958.

    Article  Google Scholar 

  20. Meneely GR, Tucker RG, Darby WJ, Auerbach SH: Chronic sodium chloride toxicity in the albino rat. II. Occurrence of hypertension and a syndrome of edema and renal failure. J Exp Med 98:71, 1953.

    Article  PubMed  CAS  Google Scholar 

  21. Meneely GR, Ball COT: Experimental epidemiology of chronic sodium chloride toxicity and the protective effect of potassium chloride. Am J Med 25:713, 1958.

    Article  PubMed  CAS  Google Scholar 

  22. Freis EDP: Salt, volume and the prevention of hypertension. Circulation 53:589, 1976.

    PubMed  CAS  Google Scholar 

  23. Dahl LK: Salt and hypertension. Am J Clin Nutr 25:231, 1972.

    PubMed  CAS  Google Scholar 

  24. Padfield PL, Brown JJ, Lever AF, Scalekamp MAD, Beevers DG, Davies DL, Robertson JIS, Tree M: Is low renin hypertension a stage in the development of essential hypertension or a diagnostic entity? Lancet 1:548, 1975.

    Article  PubMed  CAS  Google Scholar 

  25. Page LB: Hypertension and atherosclerosis in primitive and acculturating societies. In: Hunt JC, Cooper T, Fröhlich ED, Gifford RW, Kaplan NM, Laragh JH, Maxwell MH, Strong CG (eds) Hypertension update: mechanisms, epidemiology, evaluation, and management. Bloomfield NJ: Health Learning Systems, 1980.

    Google Scholar 

  26. Shaper AG: Cardiovascular disease in the tropics. III. Blood pressure and hypertension. Br Med J 3:805, 1972.

    Article  PubMed  CAS  Google Scholar 

  27. Walker WG, Whelton PK, Saito H, Russell RP, Hermann J: Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects Hypertension 1:287, 1979.

    PubMed  CAS  Google Scholar 

  28. Cooke CR, Ruiz-Maza F, Kowarski A, Migeon CJ, Walker WG: Regulation of plasma aldosterone concentration in anephric man and renal transplant recipients. Kidney Int 3:160, 1973.

    Article  PubMed  CAS  Google Scholar 

  29. Bayard F, Cooke CR, Tiller DJ, Beitins IZ, Kowarski A, Walker WG, Migeon CJ: The regulation of aldosterone secretion in anephric man. J Clin Invest 50:1585, 1971.

    Article  PubMed  CAS  Google Scholar 

  30. Cooke CR, Horvath JS, Moore MA, Walker WG: Modulation of plasma aldosterone concentration by plasma potassium in anephric man in absence of change in potassium balance. J Clin Invest 52:3028, 1973.

    Article  PubMed  CAS  Google Scholar 

  31. Walker WG, Cooke CR: Plasma aldosterone regulation in anephric man. Kidney Int 3:1, 1973.

    Article  PubMed  CAS  Google Scholar 

  32. Gann DS, Gill Jr JR, Thomas JP, Bartter FC: Control of aldosterone secretion by change of body potassium in hormonal man. Am J Physiol 207:104, 1964.

    PubMed  CAS  Google Scholar 

  33. Walker WG, Saito H, Whelton PK, Russel RP, Hermann J: Blood pressure, renin, renin substrate, aldosterone and urinary electrolytes in ambulatory patients. In: Thurm RH (ed) Essential hypertension. Chicago: Year Book Medical, 1979, p 317.

    Google Scholar 

  34. Walker WG, Moore MA, Horvath JS, Whelton PK: Arterial and venous angiotensin II in normal subjects. Relation to plasma renin activity, plasma aldosterone concentration, and response to posture and volume changes. Circ Res 38:477, 1976.

    PubMed  CAS  Google Scholar 

  35. Walker WG, Horvath JS, Moore MA, Whelton PK, Russell RP: Relation between plasma renin activity, angiotensin, and aldosterone and blood pressure in mild untreated hypertension. Circ Res 38:470, 1976.

    PubMed  CAS  Google Scholar 

  36. Priddle WW: Observations on the management of hypertension. Can Med Assoc J 25:5, 1931.

    PubMed  CAS  Google Scholar 

  37. McQuarrie I, Thompson WH, Anderson JA: Effects of excessive ingestion of sodium and potassium salts on carbohydrate metabolism and blood pressure in diabetic children. J Nutr 11:77, 1936.

    CAS  Google Scholar 

  38. Addison WLT: The use of sodium chloride, potassium chloride, sodium bromide and potassium bromide in cases of arterial hypertension which are amenable to potassium chloride. Can Med Assoc J 18:281, 1928.

    PubMed  CAS  Google Scholar 

  39. Davies HW, Haidane JBS, Kennaway EL: Experiments on the regulation of blood alkalinity. J Physiol 54:32, 1920-21.

    PubMed  CAS  Google Scholar 

  40. Bunge G: Über die Bedeutung des Kochsalzes und das Verhalten der kalisalze im menschlichen Organismus. Z Biol 9:104, 1873.

    Google Scholar 

  41. Dahl LK, Heine M, Thompson K: Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ Res 40:94, 1974.

    PubMed  CAS  Google Scholar 

  42. Hamilton M, Pickering GW, Roberts JA, Sowry GSC: Arterial pressures of relatives of patients with secondary and malignant hypertension. Clin Sci 24:91, 1963.

    PubMed  CAS  Google Scholar 

  43. Dahl LK, Heine M, Tassinari L: Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 194:480, 1962.

    Article  PubMed  CAS  Google Scholar 

  44. Dahl LK, Heine M, Tassinari L: Effect of chronic excess salt ingestion. Role of genetic factors in both DOCA-salt and renal hypertension. J Exp Med 118:605, 1963.

    Article  PubMed  CAS  Google Scholar 

  45. Tobian L, Lange J, Azar S, Iwai J, Koop D, Coffee K, Johnson MA: Reduction of natriuretic capacity and renin release in isolated blood-perfused kidneys by Dahl hypertension-prone rats. Circ Res 43:1–92, 1978.

    Google Scholar 

  46. Meneely GR, Ball COT, Youmans JB: Chronic sodium chloride toxicity: Protective effect of added potassium chloride. Ann Intern Med 47:263, 1957.

    PubMed  CAS  Google Scholar 

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Authors
  1. W. G. Walker
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Editors and Affiliations

  1. Department of Cardiology, St.-Rafaël University Hospital, Leuven, Belgium

    H. Kesteloot

  2. Department of Epidemiology, St.-Rafaël University Hospital, Leuven, Belgium

    J. V. Joossens

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© 1980 Martinus Nijhoff Publishers bv, The Hague/Boston/London

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Walker, W.G. (1980). Relationships between Sodium and Potassium Intake and Blood Pressure. In: Kesteloot, H., Joossens, J.V. (eds) Epidemiology of Arterial Blood Pressure. Developments in Cardiovascular Medicine, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8893-4_17

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  • DOI: https://doi.org/10.1007/978-94-009-8893-4_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8895-8

  • Online ISBN: 978-94-009-8893-4

  • eBook Packages: Springer Book Archive

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