Abstract
While discovery of the structure of LH-RH (Matsuo et al., 1971) and the relative ease of synthesis of the decapeptide and its analogues has led to a rapid increase in our knowledge of the control of LH and FSH secretion, the use of these gonadotropin-releasing peptides in the treatment of oligospermia and male infertility has had limited success (Schwarzstein, 1976). It thus has become important to analyze in detail the effects of such treatment with LH-RH agonists in experimental animals in an attempt to gain a better understanding of the mechanisms involved and to improve clinical treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Auclair C, Kelly PA, Labrie F, Coy DH, Schally AV (1977a) Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hor-mone agonist or human chorionic gonadotropin. Biochem Biophys Res Commun 76: 855.
Auclair C, Kelly PA, Coy DH, Schally AV, Labrie F (1977b) Potent inhibitory activity of [D-Leu6, des-Gly-NH210]LH-RH ethylamide on LH/hCG and PRL testicular receptor levels in the rat. Endocrinology 101: 1890.
Auclair C, Ferland L, Cusan L, Kelly PA, Labrie F, Azadian-Boulanger G, Raynaud JP (1978) Effet inhibiteur de la LHRH sur les récepteurs de la LH dans le testicule chez le rat. CR Acad Sci (Paris) [D] 286: 1305.
Bélanger A, Auclair C, Séguin C. Kelly PA. Labrie F (1979) Down-regulation of testicular androgen biosynthesis and LH receptor levels by an LHRH agonist: role of prolactin. Mol Cell Endocrinol 13: 47.
Bélanger A, Auclair C, Ferland L, Labrie F (1980a) Time-course of the effects of treatment with a potent LHRH agonist on testicular steroidogenesis and gonadotropin receptor levels in the adult rat. J Steroid Biochem 13: 191.
Bélanger A, Labrie F, Lemay A, Caron S, Moore S, Raynaud JP, (1980b) Inhibitory effects of a single intranasal administration of [D-Ser(TBU)6, des-Gly-NH210]LHRH ethylamide, a potent LHRH agonist, on serum steroid levels in normal adult men. J Steroid Biochem (in press).
Cigorraga SB, Dufau ML, Catt KJ (1978) Regulation of luteinizing hormone receptors and steroidogenesis in gonadotropin-desensitized Leydig cells. J Biol Chem 254: 4297.
Cusan L, Auclair C, Bélanger A, Ferland L, Kelly PA, Séguin C, Labrie F (1979) Inhibitory effects of long-term treatment with an LHRH agonist on the pituitary-gonadal axis in male and female rats. Endocrinology 104: 1369.
Labrie F. Auclair C, Cusan L. Kelly PA. Pelletier G. Ferland L (1978) Inhibitory effect of LHRH and its agonists on testicular gonadotropin receptors and spermatogenesis in the rat. Int J Androl [Suppl 2]: 303.
Matsuo H, Baba Y, Nair RMG, Arimura A, Schally AV (1971) Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun 43: 1334.
Pelletier G, Cusan L, Auclair C, Kelly PA, Desy L, Labrie F (1978) Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, des-Gly-NH210]LHRH ethylamide. Endocrinology 103: 641.
Sandow J, Recherberg WV, Köning W, Hahn M, Jerzabek G, Fräser H (1978) Physiological studies with highly active analogues of LHRH. In: Gupta D, Voelter w (eds) Hypothalamic hormone—chemistry, physiology and clinical applications. Chemie, p 307.
Schwarzstein L (1976) Diagnostic and therapeutic use of LHRH in the infertile man. In: Labrie F, Meites J, Pelletier G (eds) Hypothalamus and endocrine functions. Plenum, p 73.
Smith R, Donald RA, Espiner EA, Stromach SG, Edwards IA (1979) Normal adults and subjects with hypogonadotropin hypogonadism respond differently to [D-Ser(TBU)6, des-Gly- NH210]LHRH-EA. J Clin Endocrinol Metab 48: 167.
Wiegelman W, Solback HG, Kley MK, Nieschlag E, Rudorff KH, Kruskemper ML (1978) A new LHRG analogue: [D- Ser(TBU)6, des-Gly-NH2 10]LHRH-(l-9)-nonapeptide ethylamide. In: Gupta D. Voelter M (eds) Hypothalamic hormone-chemistry, physiology and clinical applications. Chemie, p 327.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Martinus Nijhoff Publishers bv. The Hague/Boston/London
About this chapter
Cite this chapter
Labrie, F. et al. (1980). LH-RH Agonists: Inhibition of Testicular Functions and Possible Clinical Applications. In: Cunningham, G.R., Schill, WB., Hafez, E.S.E. (eds) Regulation of Male Fertility. Clinics in Andrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8875-0_7
Download citation
DOI: https://doi.org/10.1007/978-94-009-8875-0_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8877-4
Online ISBN: 978-94-009-8875-0
eBook Packages: Springer Book Archive