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Hormonal Regulation of Testicular Function

  • Chapter
Regulation of Male Fertility

Part of the book series: Clinics in Andrology ((CLAN,volume 5))

Abstract

The testis has two functions: spermatogenesis and androgen production, mainly testosterone. These two functions are localized in different compartments in the testis: the first in the seminiferous tubules, the second in the Leydig cells situated in the interstitial tissue. Spermatogenesis and testosterone secretion depend upon the pituitary, specifically, on the gonadotrophins. Through feedback mechanisms, these two functions in turn control the secretion of hypothalamic LH-RH and of the gonadotrophins upon which they depend. These interrelationships result in a hypothalamo- hypophysotesticular secretory axis which undergoes self-regulation. We shall examine the control of androgen secretion and of spermatogenesis in turn and then the feedback mechanisms which affect hypothalamopituitary secretion.

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References

  • Aragona C, Bohnet HG, Friesen HB (1977) Localization of prolactin binding in prostate and testis: the role of serum prolactin concentration on the testicular LH receptor. Acta Endocrinol (Kbh) 84: 402.

    CAS  Google Scholar 

  • Bartke A (1976) Pituitary-testis-relationship. Role of prolactin in the regulation of testicular function. Prog Reprod Biol 1: 136.

    CAS  Google Scholar 

  • Bixler EO, Santen RJ, Kales A, Soldator CR, Scharf MB (1977) Inverse effects of thioridazine (Mellaril ®) on serum prolactin and testosterone concentrations in normal men. In: Troen Ph Nankin RH (eds) The testis in normal and infertile men. New York: Raven p 403.

    Google Scholar 

  • Bullough WS (1967) The evolution of differentiation. New York: Academic.

    Google Scholar 

  • Catt KJ, Dufau ML (1973) Interactions of LH and HCG with testicular gonadotrophin receptors. Adv Exp Med Biol 36: 379.

    PubMed  CAS  Google Scholar 

  • Catt KJ, Tsuruhara T, Mendelson C, Ketelslegers JM, Dufau ML (1974) Gonadotrophin binding and activation of the interstitial cells of the testis. Curr Top Mol Endocrinol 1: 1.

    PubMed  CAS  Google Scholar 

  • Charreau EH, Attramadal A, Torjesen PA, Purvis K, Calandra R, Hansson V (1977) Prolactin binding in rat testis: specific receptors in interstitial cells. Mol Cell Endocrinol 6: 303.

    Article  PubMed  CAS  Google Scholar 

  • Chowdhury AK (1979) Dependence of testicular germ cells on hormones: a quantitative study in hypophysectomized testosterone-treated rats. J Endocrinol 82: 331.

    Article  PubMed  CAS  Google Scholar 

  • Clermont Y, Mauger A (1974) Existence of a spermatogonial chalone in the rat testis. Cell Tissue Kinet 7: 165.

    PubMed  CAS  Google Scholar 

  • Clermont Y, Mauger A (1976) Effect of a spermatogonial chalone on the growing rat testis. Cell Tissue Kinet 9: 99.

    PubMed  CAS  Google Scholar 

  • Dorrington JH, Vernon RG, Fritz IB (1972) The effect of gonadotropins on the 3’5’-AMP levels of seminiferous tubules. Biochem Biophys Res Commun 46: 1523.

    Article  PubMed  CAS  Google Scholar 

  • Dorrington JH, Fritz IB (1975) Cellular localization of 5 α- reductase and 3 α -hydroxysteroid dehydrogenase in the seminiferous tubule in the rat testis. Endocrinology 96: 879.

    Article  CAS  Google Scholar 

  • Dorrington JH, Fritz IB, Armstrong DT (1976) Site at which FSH regulates estradiol-17β biosynthesis in Sertoli cell preparations in culture. Mol Cell Endocrinol 6: 117.

    Article  PubMed  CAS  Google Scholar 

  • Dufau ML, Catt KJ, Tsuruhara T (1971) Gonadotrophin stimulating of testosterone production by the rat testis ‘in vitro’. Biochem Biophys Acta 252: 574.

    PubMed  CAS  Google Scholar 

  • Elkington JSH, Sanborn BM, Steinberger E (1975) The effect of testosterone proprionate on the concentration of testicular and epididymal androgen binding activity in hypophysec-tomized rat. Mol Cell Endocrinol 2: 157.

    Article  PubMed  CAS  Google Scholar 

  • Franchimont P, Roulier R (1977) Gonadotrophin secretion in male subject. In: Besser M, Martini L (eds) Clinical endocrinology. New York: Academic, p 197.

    Google Scholar 

  • Franchimont P, Chari S, Demoulin A (1975) Hypothalamus- pituitary-testis interaction. J Reprod Fert 44: 335.

    Article  CAS  Google Scholar 

  • Franchimont P, Verstraelen-Proyard J, Hazee-Hagelstein MT, Renard Ch, Demoulin A, Bourguignon JP, Hustin J (1979) Inhibin: from concept to reality. Vitam Horm (submitted for publication).

    Google Scholar 

  • French FS, Ritzen EM (1973) Androgen-binding protein in efferent duct fluid of rat testis. J Reprod Fert 32: 479.

    Article  CAS  Google Scholar 

  • Greep RO, van Dyke HB, Chow BF (1942) Gonadotropins of the swine pituitary. I. Various biological effects of purified thylakentrin (FSH) and pure metakentrin ( ICSH ). Endocrinology 30: 635.

    Google Scholar 

  • Hochereau de Reviers MTh, Courot M (1978) Sertoli cells and development of seminiferous epithelium. Ann Biol Anim Biochim Biophys 18: 573.

    Article  CAS  Google Scholar 

  • Jeffcoate SL (1975) The control of testicular function in the adults. Clin Endocrinol Metab 4: 521.

    Article  PubMed  CAS  Google Scholar 

  • Johnson BJ, Ewing LL (1971) Follicle-stimulating hormone and the regulation of testosterone secretion in rabbit testes. Science 173: 635.

    Article  PubMed  CAS  Google Scholar 

  • Kulin HE, Santen RJ (1976) Endocrinology of puberty in man. In: Spilman CH, Labl TL, Kirton KT (eds) Regulatory mechanisms of male reproductive physiology. Amsterdam: Excerpta Medica, North-Holland, p 175.

    Google Scholar 

  • Labrie F, Lagace L, Ferland L, Kelly PA, Drouin J, Massicotte J, Bonne CI, Raynaud JP, Dorrington JH (1978) Interactions between LHRH, sex steroids and ‘inhibin’ in the control of LH and FSH secretion. Int J Androl 2 [Suppl]: 81.

    Article  CAS  Google Scholar 

  • Legros J J, Demoulin A, Burger HG, Franchimont P (1974) Influence d’une dose faible d’éthinyl oestradiol sur la libération pulsatile des gonadotrophines et sur la libération hypophysaire sous l’influence du LRH chez l’homme. CR Soc Biol (Paris) 168: 1432.

    CAS  Google Scholar 

  • Lindner HR (1961) Androgens and related compounds in the spermatic vein blood of domestic animals. I. Neutral steroids secreted by bull testis. J Endocrinol 23: 139.

    Article  PubMed  CAS  Google Scholar 

  • Lostroh AJ, Squire PG, Li CH (1958) Bioassay of interstitial cell-stimulating hormone in the hypophysectomized male rat by the ventral prostate test. Endocrinology 62: 833.

    Article  PubMed  CAS  Google Scholar 

  • McCullagh DD (1932) Dual endocrine activity of the testis. Science 76: 19.

    Article  PubMed  CAS  Google Scholar 

  • Marynick SP, Loriaux DL, Sherins RJ, Pita JC Jr, Lipsett MB (1979) Evidence that testosterone acts as both an androgen and an estrogen in suppressing pituitary gonadotropin secretion in man. J Clin Endocrinol Metab 49: 396.

    Article  PubMed  CAS  Google Scholar 

  • Means AR (1975) Biochemical affects of follicle-stimulating hormone on the testis. Endocrinology 5: 203.

    CAS  Google Scholar 

  • Moger WH, Amstrong DT (1974) Changes in serum testosterone levels following acute LH treatment in immature and mature rats. Biol Reprod 11: 1.

    Article  PubMed  CAS  Google Scholar 

  • Mougdal NR (1979) Use of highly purified antisera to FSH in studies on hormonal regulation of spermatogenesis. Proceedings of the report on passive immunization of male monkey (Macaca radiata) chronically with characterized FSH anti-serum. Reprod Fertil [Suppl] 26: 147.

    Google Scholar 

  • Moyle WR, Ramachandran J (1973) Effect of LH on steroidogenesis and cyclic AMP accumulation in rat Leydig cell preparations and mouse tumour Leydig cells. Endocrinology 93: 127.

    Article  PubMed  CAS  Google Scholar 

  • Murad F, Strauch BS, Vaughan M (1969) The effect of gonado-tropins on testicular adenyl cyclase. Biochem Biophys Acta 177: 591.

    PubMed  CAS  Google Scholar 

  • Odell WD, Swerdloff RS (1976) Etiologies of sexual maturation: a model system based on the sexually maturing rat. Recent Prog Horm Res 32: 245.

    PubMed  CAS  Google Scholar 

  • Odell WD, Swerdloff RS, Jacobs HS, Hescox MA (1973) FSH Induction of sensitivity to LH: one cause of sexual maturation in the male rat. Endocrinology 92: 160.

    Article  PubMed  CAS  Google Scholar 

  • Orth J, Christensen AK (1978) Autoradiographic localization of specifically bound 125I-labeled follicle-stimulating hormone on spermatogonia of the rat testis. Endocrinology 103: 1944.

    Article  PubMed  CAS  Google Scholar 

  • Qazi MH, Romani P, Diczfalusy E (1974) Discrepancies in plasma LH activities as measured by radioimmunoassay and an ‘in vitro’ bioassay. Acta Endocrinol (Kbh) 77: 672.

    CAS  Google Scholar 

  • Rommerts FFG, Cooke BA, Kemp JWCM, Van der Molen H J (1972) Stimulation of 3’,5’-cyclic AMP and testosterone production in rat testis ‘in vitro’. FEBS Lett 24: 251.

    Article  PubMed  CAS  Google Scholar 

  • Rubin RT, Poland RE, Sobel I, Tower BB, Odell WD (1978) Effects of prolactin and prolactin plus luteinizing hormone on plasma testosterone levels in normal adult men. J Clin Endocrinol Metab 47: 447.

    Article  PubMed  CAS  Google Scholar 

  • Santen RJ (1975) Is aromatization of testosterone to estradiol required for inhibition of luteinizing hormone secretion in men? J Clin Invest 56: 1555.

    Article  PubMed  CAS  Google Scholar 

  • Simpson ME, Li CH, Evans HM (1951) Synergism between pituitary follicle stimulating hormone (FSH) and human chorionic gonadotrophin (HCG). Endocrinology 48: 370.

    Article  PubMed  CAS  Google Scholar 

  • Sivashankar S, Prasad MRN, Thampan TNRV (1977) Effects of a highly purified antiserum to FSH on testicular function in immature rats. Indian J Exp Biol 15: 845.

    PubMed  CAS  Google Scholar 

  • Sizonenko PC, Pappaport R, Josso N, Dray F (1977) FSH. II. Evidence for its mediating role on testosterone secretion in hypopituitarism. Acta Endocrinol (Kbh) 84: 390.

    CAS  Google Scholar 

  • Steinberger E (1971) Hormonal control of mammalian sper-matogenesis. Physiol Rev 52: 1.

    Google Scholar 

  • Steinberger E, Steinberger A, Sanborn BM (1978) Molecular mechanisms concerned with hormonal control of the semini-ferous epithelium. In: Fabbrini A, Steinberger E (eds) Recent progress in andrology. London, New York: Academic, p 143.

    Google Scholar 

  • Tcholakian RK. Chowdhury M, Steinberger E (1974) Time of action of oestradiol-17β on luteinizing hormone and testosterone. J Endocrinol 63: 411.

    Article  PubMed  CAS  Google Scholar 

  • Van Damme MP. Robertson DM, Diczfalusy E (1974) An improved ‘in vitro’ bioassay method for measuring luteinizing hormone (LH) activity using mouse Leydig cell preparations. Acta Endocrinol (Kbh 77: 655.

    Google Scholar 

  • Vernon RG. Kopec B, Fritz IB (1974) Observations on the binding of androgens by rat testis seminiferous tubules and testis extracts. Mol Cell Endocrinol 1: 167.

    Article  CAS  Google Scholar 

  • Vigersky RA. Easley RB, Loviaux DL (1976) Effect of fluoximesterone on the pituitary-gonadal axis: the role of testosterone-estradiol-binding globulin. J Clin Endocrinol Metab 43: 1.

    Article  PubMed  CAS  Google Scholar 

  • Woods MC, Simpson ME (1961) Pituitary control of the testis of the hypophysectomized rat. Endocrinology 69: 91.

    Article  PubMed  CAS  Google Scholar 

  • Yanaihara T, Troen P, Troen BR, Troen ML (1972) Studies of the human testis. III. Effect of estrogen on testosterone formation in human testis ‘in vitro’. J Clin Endocrinol Metab 34: 968.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. P. Franchimont
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Veterans Administration Center, 2002 Holcome Blvd., Houston, TX, 77211, USA

    G. R. Cunningham

  2. Andrology Unit of the Department of Dermatology, University of Munich, D-8000, Munich 2, Frauenlobstr. 9-11, West Germany

    W.-B. Schill

  3. Department of Gynecology-Obstetrics, Wayne State University School of Medicine, Medical Research Building, 550 E. Canfield Ave., Detroit, MI, 48201, USA

    E. S. E. Hafez

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© 1980 Martinus Nijhoff Publishers bv. The Hague/Boston/London

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Franchimont, P. (1980). Hormonal Regulation of Testicular Function. In: Cunningham, G.R., Schill, WB., Hafez, E.S.E. (eds) Regulation of Male Fertility. Clinics in Andrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8875-0_1

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  • DOI: https://doi.org/10.1007/978-94-009-8875-0_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8877-4

  • Online ISBN: 978-94-009-8875-0

  • eBook Packages: Springer Book Archive

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