Interstitial Cells and Related Structures

  • S. S. Guraya
  • P. M. Motta
Part of the Developments in Obstetrics and Gynecology book series (DIOG, volume 2)


Although during the last ten years the interstitial cells of the ovary have been extensively studied with refined histochemical, biochemical and ultrastructural methods, many aspects of the histophysiology of this important ovarian component are still very poorly understood.


Lipid Droplet Corpus Luteum Interstitial Cell Smooth Endoplasmic Reticulum Atretic Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Amoroso, E.C., Bourne, G.H., Harrison, R.J., Matthews, L.H., Rowlands, I.W. and Sloper, J.C., Reproductive and endocrine organs of foetal, newborn and adult seals. J. Zool. 147: 430, 1965.Google Scholar
  2. Armstrong, D.T. and Flint, A.P.F., Isolation and properties of cholesterol ester-storage granules. Biochem. J. 134: 399, 1973.PubMedGoogle Scholar
  3. Armstrong, D.T., Jackanicz, T.M. and Keyes, P.L., Regulation of steroidogenesis in the rabbit ovary. In: The gonads, (ed. K.W. McKerns), Appleton-Century-Crofts, New York, pp. 3–26, 1969.Google Scholar
  4. Baillie, A.H., Ferguson, M.M. and Hart D. McK., Developments in steroid histochemistry. Academic Press, New York, 1966.Google Scholar
  5. Bjersing, L., Ovarian histochemistry. In: The ovary, (eds. S. Zuckerman and B.J. Weir), Academic Press, New York, vol. 1, pp. 303–391, 1977.Google Scholar
  6. Boucek, R., Telegdy, J., and Savard, K., Influence of gonadotropin on histochemical properties in the rabbit ovary. Acta Endocr. 54: 295, 1967.PubMedGoogle Scholar
  7. Carithers, J.R., Ultrastructure of rat ovarian interstitial cells III: response to luteinizing hormone. J. Ultrastruct. Res. 55: 96, 1976.PubMedCrossRefGoogle Scholar
  8. Carithers, J.R., and Green, J.A., Ultrastructure of rat ovarian interstitial cells I: normal structure and regressive changes following hypophysectomy. J. Ultrastruct. Res. 39: 239, 1972a.PubMedCrossRefGoogle Scholar
  9. Carithers, J.R. and Green, J.A., Ultrastructure of rat ovarian interstitial cells II: response to gonadotropins. J. Ultrastruct. Res. 39: 251, 1972b.PubMedCrossRefGoogle Scholar
  10. Christensen, A.K., Leydig cells. In: Handbook of physiology, section 7: Endocrinology, vol. 5: Male reproductive system (ed. R.O. Greep and E.B. Astwood), American Physiological Society, Washington, D.C., pp. 57–94, 1975.Google Scholar
  11. Claesson, L., Quantitative relationship between gonadotropic stimulation and lipid changes in the interstitial gland of the rabbit ovary. Acta Physiol. Scand. 31 (suppl. 113): 23, 1954.Google Scholar
  12. Claesson, L., Diczfalusy, E., Hillarp, N. and Hogberg, B., The formation mechanism of estrogenic hormones III: lipids of the pregnant rabbit ovary and their changes at gonadotropic stimulation. Acta Physiol. Scand. 16: 183, 1948.CrossRefGoogle Scholar
  13. Davenport, G.R. and Mallete, L.E., Some biochemical properties of rabbit ovarian hydroxysteroid dehydrogenases. Endocrinol. 78: 672, 1966.CrossRefGoogle Scholar
  14. Davies, J. and Broadus, C.D., Studies on the fine structure of steroid-secreting cells in the rabbit I: the normal interstitial cell. Am. J. Anat. 123: 441, 1968.PubMedCrossRefGoogle Scholar
  15. De Groodt, M. Lagasse A. and Seybruyns, M., L’Espace périvasculaire dans le tissu interstitiel de l’ovaire vu au microscope électronique. Bull. Microsc. Appl. 7: 101, 1957.Google Scholar
  16. Dorrington, J.H. and Kilpatrik, R., The synthesis of progestational steroids by the rabbit ovary. The gonads (ed. K.W. McKerns), Appleton-Century-Crofts, New York, pp. 27–54, 1969.Google Scholar
  17. Elfont, E.A., Roszka, J.P. and Dimino, M.J., Cytochemical studies of acid phosphatase in ovarian follicles: a suggested role for lysosomes in steroidogenesis. Biol. Reprod. 17: 787, 1977.PubMedCrossRefGoogle Scholar
  18. Endroczi, E., Hayward, J.N., Hilliard, J., Sawyer, C.H., Progestational steroidogenesis in the prepuberal rabbit ovary. Fed. Proc. 23: 109, 1964.Google Scholar
  19. Falk, B., Menander, K. and Nordanstedt, O., Androgen secretion by rat ovary. Nature 193: 593, 1962.CrossRefGoogle Scholar
  20. Familiari, G., Correr, S. and Motta, P., Microperoxisomes in steroidogenic cells of the rat ovary: interstitial, thecal and luteal cells. Proc. Int. Congr. Histochem. Cytochem. 5: 109–110, 1976.Google Scholar
  21. Familiari, G., Renda, T. and Motta, P., Surface coat in steroid secreting. Acta Anat. 100: 193, 1978.PubMedCrossRefGoogle Scholar
  22. Flint, A.P.F. and Armstrong, D.T., Activities of enzymes responsible for steroid biosynthesis and cholesterol ester metabolism in rabbit ovarian interstitial tissue and corpora lutea. Biochem. J. 132: 301, 1973.PubMedGoogle Scholar
  23. Flint, A.P.F., Grinwich, D.L. and Armstrong, D.T., Control of ovarian cholesterol ester biosynthesis. Biochem. J. 132: 313, 1973.PubMedGoogle Scholar
  24. Forbes, T.R., Preovulatory progesterone in the peripheral blood of rabbits. Endocrinol. 53: 79, 1953.CrossRefGoogle Scholar
  25. Green, J.A., Garcilazo, J.A. and Maqueo, M., Ultrastructure of the human ovary III: canaliculi of the corpus luteum. Am. J. Obstet. Gynecol. 102: 57, 1968.PubMedGoogle Scholar
  26. Guraya, S.S., Cytochemical observations concerning the formation, release and transport of secretory lipid products in the interstitial (thecal) gland cells of rabbit ovary. Z. Zellforsch. 73: 187, 1967.CrossRefGoogle Scholar
  27. Guraya, S.S., A comparative histochemical study of theca interna in the mammalian ovary. Acta Morphol. Neerl. Scand. 7: 51, 1968.PubMedGoogle Scholar
  28. Guraya, S.S., Morphology, histochemistry and biochemistry of the human ovarian compartments and steroid hormone synthesis. Physiol. Rev. 51: 785, 1971.PubMedGoogle Scholar
  29. Guraya, S.S., Comparative studies on the histochemical features of ovarian compartments in the rat and golden hamster with special reference to steroid hormone synthesis. Acta Anat. 82: 284, 1972.PubMedCrossRefGoogle Scholar
  30. Guraya, S.S., Interstitial gland tissue of mammalian ovary. Acta Endocr. 72 (suppl. 171): 1, 1973.Google Scholar
  31. Guraya, S.S., Comparative morphological and histochemical observations on the ovarian stromal compartment in mammals with special reference to steroidogenesis. Acta Anat. 90: 250, 1974.PubMedCrossRefGoogle Scholar
  32. Guraya, S.S., Histochemical observations on the lipid changes in the ovarian interstitial gland tissue of rats. J. Reprod. Fert. 45: 141, 1975.CrossRefGoogle Scholar
  33. Guraya, S.S., Histochemical observations on the gonadotrophic regulation of cholesterol-positive lipid droplets in the ovaries of hypophysectomized rats. Ind. J. Exp. Biol. 15: 615, 1976.Google Scholar
  34. Guraya, S.S., Recent advances in the morphology, histochemistry and biochemistry of the developing mammalian ovary. Int. Rev. Cytol. 51: 49, 1977a.PubMedCrossRefGoogle Scholar
  35. Guraya, S.S., Histochemical observation on the guinea pig ovary during pregnancy and lactation. Arch. Ital. Anat. Embriol. 82: 193, 1977b.PubMedGoogle Scholar
  36. Guraya, S.S., Histochemical observations on the lipid changes of corpora lutea in the PMSG-treated and cycling intact hamsters. Ind. J. Exp. Biol. 15: 181, 1977c.Google Scholar
  37. Guraya, S.S., Recent advances in the morphology, histochemistry, biochemistry and physiology of interstitial gland cells in the mammalian ovary. Int. Rev. Cytol. 55: 171, 1978a.PubMedCrossRefGoogle Scholar
  38. Guraya, S.S., Morphological and histochemical observations on the interstitial gland tissue of the pregnant hare (Lepus nigricollis) ovary. Arch. Ital. Anat. Embriol. 83: 251, 1978b.PubMedGoogle Scholar
  39. Guraya, S.S. and Chaudhary, S.K., Morphological and histochemical observations on the follicular growth and atresia, and interstitial gland tissue in the ovaries of lactating field rats (Millardia meltada). In: Readings in basic and applied zoology (eds. N.H. Kahn and S.V.S. Rana), Jedenohe, Mujaffarnagar, India, pp. 10–19, 1979.Google Scholar
  40. Guraya, S.S. and Greenwald, G.S., A comparative histochemical study of interstitial tissue and follicular atresia in the mammalian ovary. Anat. Rec. 149: 411, 1964a.PubMedCrossRefGoogle Scholar
  41. Guraya, S.S., and Greenwald, G.S., Histochemical studies on the interstitial gland in the rabbijt ovary. Amer. J. Anat. 114: 495, 1964b.PubMedCrossRefGoogle Scholar
  42. Guraya, S.S., and Greenwald, G.S., A histochemical study of the hamster ovary. Amer. J. Anat. 116, 256, 1965.CrossRefGoogle Scholar
  43. Guraya, S.S. and Gupta, S.K., Morphology and histochemistry of ovarian changes in the field rat, Millardia meltada. Mikrosk. Anat. Forsch., Leipzig 93: 959, 1979.Google Scholar
  44. Guraya, S.S., Stegner, H.E. and Pape, C., Correlative histochemical and ultrastructural studies on fetal and early postnatal guinea pig ovaries, with special reference to the development of interstitial cell system. Cytobiologie 9: 100, 1974.PubMedGoogle Scholar
  45. Hilliard, J., Spies, H.G. and Sawyer, C.H., Hormonal factors regulating ovarian cholesterol mobilization and progestin secretion in intact and hypophysectomized rabbits. In: The gonads (ed. K.W. McKerns), Appleton-Century-Crofts, New York, pp. 55–92, 1969.Google Scholar
  46. Lawrence Jr., I.E., Burden, H.E. and Capps, M.L., Ultrastructure of rat ovarian interstitial cells during pregnancy. Cell Tiss. Res. 184: 143, 1977.CrossRefGoogle Scholar
  47. Merker, H.J. and Diaz-Encinas, J., Das electronenmikroskopische Bild des Ovars juveniler Ratten und Kaninchen nach Stimulierung mit PMS und HCG I: Theka und Stroma (interstitielle Drüse). Cell Tiss. Res. 94: 605, 1969.Google Scholar
  48. Mori, H. and Matsumoto, K., On the histogenesis of the ovarian interstitial gland in rabbits I: primary interstitial gland. Am. J. Anat. 129: 289, 1970.PubMedCrossRefGoogle Scholar
  49. Mossman, H.W. and Duke, K.L., Comparative morphology of the mammalian ovary. University of Wisconsin Press, Madison, 1973.Google Scholar
  50. Motta, P., Osservazioni sulla fine delle cellule interstitiali della ovaio (ricerche in Lepus cuniculus, Linn.). Biol. Lat. 19: 107 1966.PubMedGoogle Scholar
  51. Motta, P., Electron microscope study of the human lutein cell with special reference to its secretory activity. Cell Tiss. Res, 98: 233, 1969.Google Scholar
  52. Motta, P., Observations on the ultrastructure of the interstitial cells of the human ovary. Anat. Anz. 130: 1, 1972.PubMedGoogle Scholar
  53. Motta, P. Superficial epithelium and surface invaginations in the cortex of mature rabbit ovaries: a note on the histogenesis of the interstitial cell. Fert. Steril. 25: 336, 1974.Google Scholar
  54. Motta, P. The three-dimensional fine structure of the liver as revealed by scanning electron microscopy. Int. Rev. Cytol. 54 (suppl. 6): 347, 1977.Google Scholar
  55. Motta, P. and Bourneva, V., A comparative histochemical study of 5-3ß-hydroxysteroid dehydrogenase and lipid content ir the rat ovary with special reference to the interstitial cells Acta Histochem. 38: 340, 1970.PubMedGoogle Scholar
  56. Motta, P. and Porter, K.R., Structure of rat sinusoid and associated tissue spaces as revealed by scanning electron microscopy. Cell Tiss. Res. 148: 111, 1974.CrossRefGoogle Scholar
  57. Motta, P. and Takeva, Z., Histochemical demonstration of 5-3ß-hydroxysteroid dehydrogenase activity in the interstitia tissue of the guinea pig ovary during the estrous cycle and pregnancy. Fert. Steril. 22: 378, 1971.Google Scholar
  58. Motta, P., Nesci, E. and Fumagalli L., The fine structure and cyclic morphological changes of the interstitial cells in the mammalian ovary. Arch. Anat. Hist. Embr. Norm. Exp. 54 43, 1971a.Google Scholar
  59. Motta, P., Takeva, Z. and Palermo, D., On the presence of cilia in different cells of the mammalian ovary. Acta Anat. 78: 591, 1971b.PubMedCrossRefGoogle Scholar
  60. Motta, P., Calvieri, S. and Palermo D., On the occurrence of spaces similar to intercellular canaliculi in the Leydig cells of mice. Experientia 29: 1120, 1973.PubMedCrossRefGoogle Scholar
  61. Motta, P., Columbis, P. and Didio, L.J.A., Unusual arrangement of agranular endoplasmic reticulum in the interstitial cells of the cat ovary. Fert. Steril. 25: 346, 1975.Google Scholar
  62. Motta, P., Muto, M. and Fujita, T., Three-dimensional organization of mammalian adrenal cortex: a scanning electron microscopic study. Cell Tiss. Res. 196: 23, 1979.CrossRefGoogle Scholar
  63. Muta, T. The fine structure of the interstitial cell in the mouse ovary studied with electron microscope. Kurume Med. J. 5: 167, 1958.CrossRefGoogle Scholar
  64. Rambourg, A., Morphological and histochemical aspects of glycoproteins at the surface of animal cells. Int. Rev. Cytol. 31: 57, 1971.PubMedCrossRefGoogle Scholar
  65. Saidapur, S.K. and Greenwald, G.S., Sites of steroid synthesis in the ovary of the cyclic hamster: a histochemical study. Am. J. Anat. 151: 71, 1978.PubMedCrossRefGoogle Scholar
  66. Sawada, T. and Ichikawa, S., Sites of production of sex steroids: secretion of steroid from X-irradiated and polycystic ovaries of rats. Endocrinol. 102: 1436, 1978.CrossRefGoogle Scholar
  67. Solod, E.A., Armstrong, D.T. and Greep, R.O., Action of luteinizing hormone on conversion of cholesterol stores to steroids secreted in vivo and synthesized in vitro by the pseudopregnant rabbit ovary. Steroids 7: 607, 1966.PubMedCrossRefGoogle Scholar
  68. Unsicker, K. Zur Innervation der interstitiellen Drüse im Ovar der Maus (Mus musculus, Linn.). Cell. Tiss. Res. 109: 46, 1970.Google Scholar
  69. Van Blerkom, J. and Motta, P., The cellular basis of mammalian reproduction, Urban and Schwarzenberg, Munich, 1979.Google Scholar

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© Martinus Nijhoff Publishers bv, The Hague 1980

Authors and Affiliations

  • S. S. Guraya
  • P. M. Motta

There are no affiliations available

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