The Role of the Lysosomes in Ovarian Physiology

  • M. J. Dimino
  • E. A. Elfont
Part of the Developments in Obstetrics and Gynecology book series (DIOG, volume 2)


In the classical sense, lysosomes were considered primarily to be subcellular structures that contained degradative enzymes which, when released, led to the demise of the cell; but while the lysosomal system does act as a mechanism for the removal of subcellular components that are worn out or no longer needed, its role in other cellular functions must be considered (Dean and Barrett 1976). It is now apparent from a physiological point of view that the lysosomal concept should be expanded to encompass a heterogenous population of related subcellular organelles that are involved in the normal economy of the cell.


Granulosa Cell Golgi Apparatus Ovarian Tissue Corpus Luteum Lysosomal Enzyme 
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  1. Cajander, S. and Bjersing, L., Further studies of the surface epithelium covering preovulatory rabbit follicles with special reference to lysosomal alterations. Cell Tiss. Res. 169: 129, 1976.CrossRefGoogle Scholar
  2. Chen, T.T., Abel, J.H., McClellan, M.C., Sawyer, H.R., Diekman, M.A. and Niswender, G.D., Localization of gonadotropic hormone in lysosomes of ovine luteal cells. Cytobiologie 1: 412, 1977.Google Scholar
  3. Dean, R.T. and Barrett, A.J., Lysosomes. Essays Biochem. 12: 1, 1976.PubMedGoogle Scholar
  4. Dimino, M.J. and Berman, S.K., Increases in mitochondrial steroidogenesis following short term incubation of porcine ovarian follicles with LH. Endocrinol. 104: 780, 1979.CrossRefGoogle Scholar
  5. Dimino, M.J. and Reece, R.P., Effects of gonadotropic hormones on rat ovarian lysosomes. Biol. Reprod. 8: 523, 1973.PubMedGoogle Scholar
  6. Dimino, M.J., Malcom, S.E. and Elfont, E.A., Changes in acid hydrolase activities of ovarian subcellular fractions of immature rats after gonadotropic treatment. Biol. Reprod. 17: 780, 1977.PubMedCrossRefGoogle Scholar
  7. Dott, H.M., Lysosomes and lysosomal enzymes in reproduction. Adv. Reprod. Physiol. 6: 213, 1973.PubMedGoogle Scholar
  8. Elfont, E.A., Roszka, J.P. and Dimino, M.J., Cytochemical studies of acid phosphatase in ovarian follicles: a suggested role for lysosomes in steroidogenesis. Biol. Reprod. 17: 787, 1977.PubMedCrossRefGoogle Scholar
  9. Lahav, M., Meidan, R., Amsterdam, A., Gebauer, H. and Lindner, H.R., Intracellular distribution of cathepsin D in rat corpora lutea in relation to reproductive state and the action of prostaglandin F and prolactin. J. Endocr. 75: 317, 1977.PubMedCrossRefGoogle Scholar
  10. Motta, P., Electron microscope study on the human luteal cell with special reference to its secretory activity. Z. Zellforsch, 98: 233, 1969.PubMedCrossRefGoogle Scholar
  11. Novikoff, A.B. and Holtzman, E., Cells and organelles, Holt, Rinehart and Winston, New York, 1976.Google Scholar
  12. Okazaki, T., Strauss, J.F. and Flickinger, G.L., Lysosomal phospholipase A activities of rat ovarian tissue. Biochim. Biophys. Acta 487: 343, 1977.PubMedGoogle Scholar
  13. Rawson, J.M.R. and Espey, L.L., Distribution of electron dense bodies in the surface epithelium of the rabbit ovary during the process of ovulation. Fed. Proc. 35: 726, 1976.Google Scholar
  14. Sawyer, H.R., Abel, J.H., McClellan, M.C., Schmitz, M. and Niswender, G.D., Secretory granules and progesterone secretion by ovine corpora lutea in vitro. Endocrinol. 104: 476, 1979.CrossRefGoogle Scholar
  15. Strauss, J.F. and Flickinger, G.L., A role for lysosomes in corpus luteum function. In: Protein turnover and lysosomal function (ed. H.L. Segal and D. Doyle), Academic Press, New York, 1978Google Scholar

Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1980

Authors and Affiliations

  • M. J. Dimino
  • E. A. Elfont

There are no affiliations available

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