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Autonomic Nervous System and Sudden Death

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Sudden Death

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 4))

Abstract

A great deal of information exists regarding the influence of the autonomic nervous system on the electrical properties of the myocardium and on the genesis of a variety of cardiac arrhythmias. The purpose of this presentation is not to review this vast literature, but to present new information we have developed over the past several years. Specifically, in this manuscript, we will discuss the effects of the autonomic nervous system on recovery properties in the endocardium and the epicardium of the canine left ventricle (1, 2); the effects of the autonomic nervous system on myocardial activation during acute myocardial ischemia in the dog (3); and new models in which to study the effects of ischemia, including vascularized hamster cardiac allographs (4); and rodent myocardium damaged by epinephrine (5).

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References

  1. Martins JB, Zipes DP: Vagal nerve stimulation prolongs refractory period of epicardium and endocardium in the canine left ventricle. Am J Cardiol 43: 373, (abstract) 1979.

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  2. Martins JB, Zipes DP: Sympathetic nerves affect endocardial and epicardial refractory periods equivalently in the canine left ventricle. Clin Res 27: 186A, (Abstract) 1979.

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  3. Ruffy R, Lovelace DE, Zipes DP: Study of vagal and sympathetic influence on conduction in canine ventricular myocardium following coronary artery occlusion. Clin Res 26: 267A, (abstract) 1978.

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  4. Gilmour RF, Zipes DP: Transmembrane electrophysiologic properties of vascularized hamster cardiac allographs. Fed Proc 38(3): 1117, (abstract) 1979.

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  5. Gilmour RF Jr, Zipes DP: Electrophysiologic properties of epinephrine-induced necrotic myocardium. Am J Cardiol 43: 350, (abstract) 1979.

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  6. Yanowitz F, Preston JB, Abildskov JA: Functional distribution of right and left stellate innervation of the ventricles. Circ Res 18: 416–428, 1966.

    PubMed  CAS  Google Scholar 

  7. Kolman BS, Verrier RL, Lown B: Effect of vagus nerve stimulation upon excitability of the canine ventricle. Am J Cardiol 37: 1041–1045, 1976.

    Article  PubMed  CAS  Google Scholar 

  8. Bailey JC, Watanabe AM, Besch FIR Jr, Lathrop DA: Acetylcholine antagonism of the electrophysiologic effects of isoproterenol on canine cardiac Purkinje fibers. Circ Res 44: 378–383, 1979.

    PubMed  CAS  Google Scholar 

  9. Dahlstrom A, Fuxe F, Mya-Tu M, Zetterstrom BEM: Observations on adrenergic innervation of the dog heart. Am J Physiol 209: 689–692, 1965.

    PubMed  CAS  Google Scholar 

  10. Kent KM, Epstein SE, Cooper T, Jacobowitz DM: Cholinergic innervation of the canine and human ventricular conducting system. Circulation 50: 948–955, 1974.

    PubMed  CAS  Google Scholar 

  11. Krayer O, Mandoki JJ, Mendez C: Studies on veratrum alkaloids XVI. The action of epinephrine and veratramine on the functional refractory period of the auriculo-ventricular transmission in the heart-lung preparation of the dog. Am J Physiol 103: 412–419, 1951.

    CAS  Google Scholar 

  12. Waxman MB, Wald R: Termination of ventricular tachycardia by an increase in cardiac vagal drive. Circulation 56: 385–391, 1977.

    PubMed  CAS  Google Scholar 

  13. Ruffy R, Lovelace DE, Knoebel SB, Elharrar V, Zipes DP: Relationship between left ventricular electrogram and regional blood flow in acute myocardial ischemia with and without stellate stimulation. Circ Res. 45: 764–770, 1979.

    PubMed  CAS  Google Scholar 

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© 1980 Martinus Nijhoff Publishers bv, The Hague

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Zipes, D.P., Gilmour, R.F., Martins, J.B., Ruffy, R. (1980). Autonomic Nervous System and Sudden Death. In: Kulbertus, H.E., Wellens, H.J.J. (eds) Sudden Death. Developments in Cardiovascular Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8834-7_9

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  • DOI: https://doi.org/10.1007/978-94-009-8834-7_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8836-1

  • Online ISBN: 978-94-009-8834-7

  • eBook Packages: Springer Book Archive

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