Skip to main content

Prevention of Sudden Death: The Role of Beta-Blockers

  • Chapter
Sudden Death

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 4))

  • 63 Accesses

Abstract

Ischemic heart disease is the main cause of death in the western world (8, 13, 22). Most of these deaths are sudden and occur before the patient reaches hospital (8, 11, 24). It is generally accepted that sudden death is due to ventricular fibrillation in most cases, but the pathogenesis and factors predisposing to ventricular fibrillation are not well defined (6, 26). In order to prevent deaths outside hospital one has to institute prophylactic medication in patients at high risk for cardiovascular death. During the last few years, long-term treatment with beta-blocking agents has been suggested as a potentially useful therapy to reduce morbidity and mortality in ischemic heart disease. The aim of this paper is to review the studies of chronic beta-blockade in the prevention of cardiovascular death.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahlmark G, Saetre H, Korsgren M: Reduction of sudden deaths after myocardial infarction. Lancet (abstract) 2:1563, 1974.

    Article  CAS  Google Scholar 

  2. Amsterdam EA, Wolfson S, Gorlin R: Effect of therapy on survival in angina pectoris. Ann Intern Med 63:115, 1968.

    Google Scholar 

  3. A Multicentre International Study: Improvement in prognosis of myocardial infarction by long-term betaadrenoreceptor blockade using practolol. Br Med J 3:735–740, 1975.

    Article  Google Scholar 

  4. Barber JM, Boyle McC, Chaturvedi NC, Singh N, Walsh MJ: Practolol in acute myocardial infarction. Acta Med Scand suppl 587:213–216, 1976.

    PubMed  CAS  Google Scholar 

  5. Berglund G, Wilhelmsen L, Sannerstedt R, Hansson L, Andersson O, Sivertson R, Wedel H, Wikstrand J: Coronary heart disease after treatment of hypertension. Lancet 1:1–5, 1978.

    Article  PubMed  CAS  Google Scholar 

  6. Han J, Goel BG: Electrophysiological precursors of ventricular tachyarrhythmias. Arch Intern Med 129: 749–755, 1972.

    Article  PubMed  CAS  Google Scholar 

  7. Klein MS, Sobel BE: Medical management of myocardial infarction. Ann Rev Med 27:89–108, 1976.

    Article  PubMed  CAS  Google Scholar 

  8. Kuller L: Sudden and unexpected nontraumatic deaths in adults: a review of epidemiological and clinical studies. J Chron Dis 19:1165–000, 1962.

    Article  Google Scholar 

  9. Norris RM, Caughey DE, Scott Pi: Trial of propranolol in acute myocardial infarction. Br Med J 2:398–400, 1968.

    Article  PubMed  CAS  Google Scholar 

  10. Reynolds JL, Whitlock RML: Effects of a beta-adrenergic receptor blocker in myocardial infarction treated for one year from onset. Br Heart J 34:252–259, 1972.

    Article  PubMed  CAS  Google Scholar 

  11. Romo M: Factors related to sudden death in acute ischaemic disease. Acta Med Scand suppl 547:1–92, 1973.

    PubMed  CAS  Google Scholar 

  12. Snow PJD: Effect of propranolol in myocardial infarction. Lancet 2:551–553, 1965.

    Article  PubMed  CAS  Google Scholar 

  13. Stamler J: Cardiovascular diseases in the United States. Am J Cardiol 10:319–340, 1962.

    Article  PubMed  CAS  Google Scholar 

  14. Swedberg K, Hjalmarson AC, Waagstein F, Wallentin I: Prolongation of survival in Congestive cardiomyopathy by beta-receptor blockade. Lancet 1: 1374–1376, 1979.

    Article  PubMed  CAS  Google Scholar 

  15. Waagstein F, Hjalmarson AC: Effect of cardioselective beta-blockade on heart function and chest pain in acute myocardial infarction. Acta Med Scand suppl 587:193–200, 1976.

    PubMed  CAS  Google Scholar 

  16. Waagstein F, Hjalmarson AC: Double-blind study of the effect of cardioselective beta-blockade on chest pain in acute myocardial infarction. Acta Med Scand suppl 587:201–211, 1976.

    PubMed  CAS  Google Scholar 

  17. Waagstein F, Hjalmarson A, Malek I: Effect of beta-blockers in reducing infarct size. In: Acute and Longterm Medical Management of Myocardial Ischaemia, A Hjalmarson, L Wilhelmsen (eds) Astra, Sweden 1978, p 346.

    Google Scholar 

  18. Waldenström AP, Hjalmarson AC: Factors modifying ischemic injury in the isolated rat heart. Acta Med Scand 201:533–537, 1977.

    Article  PubMed  Google Scholar 

  19. Waldenström A, Hjalmarson A, Thornell L: Factors of importance for infarct size in animals - Findings of the Göteborg Group. in: Acute and Long-term Medical Management of Myocardial Ischaemia, A Hjalmarson, L Wilhelmsen, (eds) Astra, Sweden, 1978, p 221.

    Google Scholar 

  20. Vedin A, Wilhelmsson C, Elmfeldt D, Säve-Söderberg J, Tibblin G, Wilhelmsen L: Deaths and non-fatal reinfarctions during two years’ follow-up after myocardial infarction. A follow-up study of 440 men and women discharged alive from hospital. Acta Med Scand 198:353–364, 1975.

    Article  PubMed  CAS  Google Scholar 

  21. Vedin A, Wilhelmsson C, Tibblin G, Wilhelmsen L: The post-infarction clinic in Göteborg, Sweden. A controlled trial of a therapeutic organization. Acta Med Scand 200:453–456, 1976.

    Article  PubMed  CAS  Google Scholar 

  22. Vedin JA, Wilhelmsson C, Bolander AM, Werkö L: Mortality trends in Sweden 1951–1968 with special reference to cardiovascular cause of death. Acta Med Scand suppl 515:1–76, 1971.

    Google Scholar 

  23. Wilhelmsen L, Wedel H, Tibblin G: Multivariate analysis of risk factors for coronary heart disease. Circulation 48:950–958, 1973.

    PubMed  CAS  Google Scholar 

  24. Wilhelmsen L, Ljungberg S, Wedel H, Werkö L: A comparison between participants and non-participants in a primary preventive trial. J Chron Dis 29:331–339, 1976.

    Article  PubMed  CAS  Google Scholar 

  25. Wilhelmsson C, Vedin JA, Wilhelmsen L, Tibblin G, Werkö L: Reduction of sudden deaths after myocardial infarction by treatment with alprenolol. Lancet 2:1157–1159, 1974.

    Article  PubMed  CAS  Google Scholar 

  26. Vismara LA, Amsterdam EA, Mason DT: Relation of ventricular arrhythmias in the late hospital phase of acute myocardial infarction to sudden death after hospital discharge. Am J Med 59:6–12, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Baber NS: Multicentre propranolol post-infarction trial. Br Heart J 41:365–000, 1979.

    Google Scholar 

  28. Lambert DMD: Hypertension and myocardial infarction. Br Med J 3:685 (abstract), 1974.

    Article  PubMed  CAS  Google Scholar 

  29. Waagstein F, Hjalmarson A, Varnauskas E, Wallentin I: Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J 37:1022–1036, 1975.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Martinus Nijhoff Publishers bv, The Hague

About this chapter

Cite this chapter

Hjalmarson, Å. (1980). Prevention of Sudden Death: The Role of Beta-Blockers. In: Kulbertus, H.E., Wellens, H.J.J. (eds) Sudden Death. Developments in Cardiovascular Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8834-7_20

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-8834-7_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8836-1

  • Online ISBN: 978-94-009-8834-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics