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Further Evaluation of the Repetitive Ventricular Response in Man

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Sudden Death

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 4))

Abstract

Paroxysmal ventricular tachycardia and fibrillation remain a major cause of death in many countries. Despite widespread use of antiarrhythmic agents in high risk patients, the improvement in mortality has been small. This fact may be due to the trial-and-error approach to the administration of antiarrhythmic agents. Such an approach itself reflects the inability of any testing procedure to detect reliably the ventricular electrical instability which predisposes to ventricular tachycardia and fibrillation and to detect when an anti-arrhythmic agent has conferred electrical stability to a patient’s heart.

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References

  1. Wiggers CJ, Wegria N: Ventricular fibrillation due to single localized induction and condenser shocks applied during the vulnerable phase of ventricular systole. Am J Physiol 128: 500–505, 1940.

    Google Scholar 

  2. Gerstenblith G, Spear JF, Moore EN: Quantitative study of the effect of lidocaine on the threshold for ventricular fibrillation in the dog. Am J Cardiol 30: 242–247, 1972.

    Article  PubMed  CAS  Google Scholar 

  3. Merx W, Han J, Yoon MS: Effects of unipolar cathodal and bipolar stimulation on vulnerability of ischemic ventricles to fibrillation. Am J Cardiol 35: 37–41, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Han J, de Jalon G, Moe GK: Fibrillation threshold of premature ventricular responses. Circulation Res 18: 18–25, 1966.

    PubMed  CAS  Google Scholar 

  5. Burgess MJ, Williams D, Ershler P: Influence of test site on ventricular fibrillation threshold. Am Heart J 94: 55–61, 1977.

    Article  PubMed  CAS  Google Scholar 

  6. Merx W, Yoon MS, Han J: The role of local disparity in conduction and recovery time on ventricular vulnerability to fibrillation. Am Heart J 94: 603–610, 1977.

    Article  PubMed  CAS  Google Scholar 

  7. Moore EM, Spear JF: Ventricular fibrillation threshold. Its physiological and pharmacological importance. Arch Int Med 135: 446–453, 1975.

    Article  CAS  Google Scholar 

  8. Lown B, Kleiger R, Williams J: Cardioversion and digitalis drugs: Changed threshold to electric shock in digitalized animals. Circulation Res 17: 519–531, 1965.

    PubMed  CAS  Google Scholar 

  9. Lown B: Electrical stimulation to estimate the degree of digitalization. II. Experimental studies. Am J Cardiol 22: 251–259, 1968.

    Article  PubMed  CAS  Google Scholar 

  10. Thompson PL, Lown B: Sequential R/T pacing to expose electrical instability in the ischemic ventricle (abstr). Clin Res 20: 401, 1972.

    Google Scholar 

  11. Axelrod PJ, Verrier RL, Lown B: Extreme vulnerability to ventricular fibrillation with acute coronary occlusion exposed by sequential R/T pulsing (abstr). Am J Cardiol 31: 117, 1973.

    Article  Google Scholar 

  12. Matta RJ, Verrier RL, Rabinowitz SH, et al: The repetitive extrasystole as an index of ventricular vulnerability to fibrillation (abstr). Am J Cardiol 35: 156, 1975.

    Article  Google Scholar 

  13. Karagueuzian HS, Ferroglio JJ, Hoffman BF, et al: Sustained ventricular tachycardia induced by electrical stimulation after myocardial infarction: relation to infarct structure (abstr). Circulation 56:1I1–79, 1977.

    Google Scholar 

  14. Engle WR, Moore EN, Spear JF et al: Limitations on the use of electrical ventricular fibrillation threshold determinations (abstr). Circulation 55: I11–80, 1977.

    Google Scholar 

  15. Horowitz LN, Spear JF, Josephson ME, et al: Ventricular fibrillation threshold in man (abstr). Am J Cardiol 39: 274, 1977.

    Google Scholar 

  16. Guss SB, Kastor JA, Scharf DL, et al: Effects of rate, atropine and procainamide on human ventricular refractoriness (abstract). Am J Cardiol 35: 142, 1975.

    Article  Google Scholar 

  17. Engle TR, Meister SG, Frankl WS: Ventricular extrastimulation in the mitral valve prolapse syndrome. Evidence of ventricular reentry. J Electrocardiol 11: 137–142, 1978.

    Article  Google Scholar 

  18. Akhtar M, Damato AN, Batsford WP, et al: Demonstration of re-entry within the His-Purkinje system in man. Circulation 50: 1150–1162, 1974.

    PubMed  CAS  Google Scholar 

  19. Akhtar M, Gilbert C, Wolf FG, et al: Reentry within the His-Purkinje system. Elucidation of reentrant circuit using right bundle branch and His bundle recordings. Circulation 58: 295–304, 1978.

    PubMed  CAS  Google Scholar 

  20. Dhatt MS, Akhtar M, Reddy CP, et al: Modification and abolition of re-entry within the His-Purkinje system in man by diphenylhydantoin. Circulation 56: 720–726, 1977.

    PubMed  CAS  Google Scholar 

  21. Kastor JA, Josephson ME, Guss FB, et al: Human ventricular refractoriness. II. Effects of procainamide. Circulation 56: 462–467, 1977.

    PubMed  CAS  Google Scholar 

  22. Josephson ME, Horowitz LN, Farshidi A, et al: Recurrent sustained ventricular tachycardia. I. Mechanisms. Circulation 57: 431–440, 1978.

    CAS  Google Scholar 

  23. Drew TM, Josephson ME, Horowitz, LN, et al: The significance of the repetitive ventricular response to programmed ventricular stimulation. (abstr). Clin Res 25: 218A, 1977.

    Google Scholar 

  24. Wellens JH, Schuilenburg RM, Durrer D: Electrical stimulation of the heart in patients with ventricular tachycardia. Circulation 46: 216–226, 1972.

    PubMed  CAS  Google Scholar 

  25. Wellens HJJ, Lie KI, Durrer D: Further observations on ventricular tachycardia as studied by electrical stimulation of the heart. Circulation 49: 647–653, 1974.

    PubMed  CAS  Google Scholar 

  26. Wellens HJJ, Bär FWHM, Lie KI et al: Effect of procainamide, propranolol, and verapamil on mechanism of tachycardia in patients with chronic recurrent ventricular tachycardia. Am J Cardiol 40: 579–585, 1977.

    Article  PubMed  CAS  Google Scholar 

  27. Reddy CP, Damato AN, Akhtar M, et al: The effect of procainamide on re-entry within the His-Purkinje system in man (abstr). Am J Cardiol 37: 165, 1976.

    Google Scholar 

  28. Josephson ME, Horowitz LN, Farshidi A: Continuous local electrical activity. A mechanism of recurrent ventricular tachycardia. Circulation 57: 659–665, 1978.

    PubMed  CAS  Google Scholar 

  29. Josephson ME, Horowitz LN, Farshidi A, et al: Recurrent sustained ventricular tachycardia. II. Endocardial mapping. Circulation 57: 440–447, 1978.

    PubMed  CAS  Google Scholar 

  30. Fisher JD, Cohen HL, Mehra R, et al: Cardiac pacing and pacemakers. II. Serial electrophysiologic-pharmacologic testing for control of recurrent tachyarrhythmias. Am Heart J 93: 658–668, 1977.

    Article  PubMed  CAS  Google Scholar 

  31. Horowitz LN, Josephson ME, Farshidi A, et al: Recurrent sustained ventricular tachycardia. 3. Role of the electrophysiologic study in detection of antiarrhythmic regimens. Circulation 58: 986–997, 1978.

    PubMed  CAS  Google Scholar 

  32. Mason JW, Winkle RA: Electrode-catheter arrhythmia induction in the selection and assessment of antiarrhythmic drug therapy in recurrent ventricular tachycardia. Circulation 58: 971–985, 1978.

    PubMed  CAS  Google Scholar 

  33. Greene HL, Reid PR, Schaeffer AH: The repetitive ventricular response in man. A predictor of sudden death. N Engl J Med 299: 729–734, 1978.

    Article  PubMed  CAS  Google Scholar 

  34. Schaeffer AH, Greene HL, Reid PR: Suppression of the repetitive ventricular response: An index of long term antiarrhythmic effectiveness of aprindine for ventricular tachycardia in man. Am J Cardiol 42: 1007 1012, 1978.

    Google Scholar 

  35. Pederson DH, Troup PJ, Zipes DP: Prognostic significance of repetitive ventricular response using programmed ventricular pacing. Abstract. Clin Res 26: 652A, 1978.

    Google Scholar 

  36. Troup PJ, Pederson DH, Zipes DP: Effects of premature ventricular stimulation in patients with ventricular tachycardia (abstr). Circulation 58 (suppl II): II-154, 1978.

    Google Scholar 

  37. Farshidi A, Michelson EL, Greenspan AM, et al: Repetitive responses to ventricular extrastimuli-incidence, mechanism and significance (abstr). Am J Cardiol 43: 390, 1979.

    Google Scholar 

  38. Spielman SR, Farshidi A, Horowitz LN, et al: Ventricular fibrillation during programmed ventricular stimulation: Incidence and clinical implications. Am J Cardiol 42: 913–918, 1978.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. L. Greene
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  2. Ph. R. Reid
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  3. A. H. Schaeffer
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Editor information

Editors and Affiliations

  1. School of Medicine, Division of Cardiology, University of Liège, Liège, Belgium

    H. E. Kulbertus

  2. Department of Cardiology, Annadal Hospital, University of Limburg, Maastricht, Netherlands

    H. J. J. Wellens

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© 1980 Martinus Nijhoff Publishers bv, The Hague

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Greene, H.L., Reid, P.R., Schaeffer, A.H. (1980). Further Evaluation of the Repetitive Ventricular Response in Man. In: Kulbertus, H.E., Wellens, H.J.J. (eds) Sudden Death. Developments in Cardiovascular Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8834-7_16

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  • DOI: https://doi.org/10.1007/978-94-009-8834-7_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8836-1

  • Online ISBN: 978-94-009-8834-7

  • eBook Packages: Springer Book Archive

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