The Role of Brain Metastases in Cascade Processes: Implications for Research and Clinical Management

  • Irwin D. J. Bross
Part of the Metastasis: A Monograph Series book series (METS, volume 2)


During the past decade, hundreds of millions of dollars have been spent each year on research and clinical technology with the purpose (or more accurately, the hope) of curing human cancer. In terms of objective criteria such as the long-term survival of patients, there is not very much to show for this expenditure of medical resources. One of the main reasons for this record of few successes and many failures is the strategic mistake that most clinicians make: the problem with cancer is not what the clinician can see but what the clinician cannot see. The problem of cancer is the problem of metastases, particularly remote occult metastases.


Brain Metastasis Lung Metastasis Primary Cancer Pulmonary Metastasis Metastatic Spread 
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  1. Blumenson, L. E., and Bross, I. D. J. A mathematical analysis of the growth and spread of breast cancer. Biometrics 25: 95–109, 1969.PubMedCrossRefGoogle Scholar
  2. Bross, I. D. J., and Blumenson, L. E. Statistical testing of a deep mathematical model for human breast cancer. J. Chronic Dis. 21: 493–506, 1968.PubMedCrossRefGoogle Scholar
  3. Bross, I. D. J.; Viadana, E.; and Pickren, J. W. The metastatic spread of myelomas and leukemias in men. Virchows arch. [Pathol. Anat.] 365: 91–101, 1975a.Google Scholar
  4. Bross, I. D. J.; Viadana, E.; and Pickren, J. W. Does generalized metastasis occur directly from the primary? J. Chronic Dis. 28: 149–159, 1975b.PubMedCrossRefGoogle Scholar
  5. Bross, I. D. J., and Blumenson, L. E. Metastatic sites that produce generalized cancer: identification and kinetics of generalizing sites. In Fundamental Aspects of Metastasis, ed. L. Weiss. Amsterdam: North- Holland Publishing Co., 1976.Google Scholar
  6. Bross, I. D. J.; Ball, M.; and Falen, S. A dosage response curve for the one rad range: adult risks from diagnostic radiation. Am. J. Public H. 69: 130–136, 1979.CrossRefGoogle Scholar
  7. Fisher, B. A. et al. Postoperative radiotherapy in the treatment of breast cancer: results of the NSABP clinical trial. Ann. Surg. 172: 711–732, 1970.PubMedCrossRefGoogle Scholar
  8. Fisher, B. A., et al. Ten-year follow-up of breast cancer patients in a cooperative clinical trial evaluating surgical adjuvants chemotherapy. Surg. Gynecol. Obstet. 140: 528–534, 1975.PubMedGoogle Scholar
  9. Slack, N. H., and Bross, I. D. J. The influence of site of metastasis on tumor growth and response to chemotherapy. Br. J. Cancer 32: 71, 1975.CrossRefGoogle Scholar
  10. Viadana, E. The metastatic spread of head and neck tumors in man (an autopsy study of 371 cases). Z. Krebsforsch. 83: 293–304, 1973.CrossRefGoogle Scholar
  11. Viadana, E.; Bross, I. D. J.; and Pickren, J. W. An autopsy study of some routes of dissemination of cancer of the breast. Br. J. Cancer 27: 336–340, 1973.PubMedCrossRefGoogle Scholar
  12. Viadana, E.; Bross, I. D. J.; and Pickren, J. W. The metastatic spread of kidney and prostate cancers in man. Neoplasma 23: 323–333, 1976a.PubMedGoogle Scholar
  13. Viadana, E.; Bross, I. D. J.; and Pickren, J. W. The spread of blood-borne metastases in malignant lymphomas of man. Oncology 33: 123–131, 1976b.PubMedCrossRefGoogle Scholar
  14. Viadana, E.; Bross, I. D. J.; and Pickren, J. W. Cascade spread of blood- borne metastases in solid and non-solid cancers of man. In Pulmonary Metastasis, ed. L. Weiss and H. A. Gilbert. Boston: G.K. Hall & Co., 1978.Google Scholar

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© G.K. Hall & Co. 1980

Authors and Affiliations

  • Irwin D. J. Bross

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