The Role of Brain Metastases in Cascade Processes: Implications for Research and Clinical Management
During the past decade, hundreds of millions of dollars have been spent each year on research and clinical technology with the purpose (or more accurately, the hope) of curing human cancer. In terms of objective criteria such as the long-term survival of patients, there is not very much to show for this expenditure of medical resources. One of the main reasons for this record of few successes and many failures is the strategic mistake that most clinicians make: the problem with cancer is not what the clinician can see but what the clinician cannot see. The problem of cancer is the problem of metastases, particularly remote occult metastases.
KeywordsBrain Metastasis Lung Metastasis Primary Cancer Pulmonary Metastasis Metastatic Spread
Unable to display preview. Download preview PDF.
- Bross, I. D. J.; Viadana, E.; and Pickren, J. W. The metastatic spread of myelomas and leukemias in men. Virchows arch. [Pathol. Anat.] 365: 91–101, 1975a.Google Scholar
- Bross, I. D. J., and Blumenson, L. E. Metastatic sites that produce generalized cancer: identification and kinetics of generalizing sites. In Fundamental Aspects of Metastasis, ed. L. Weiss. Amsterdam: North- Holland Publishing Co., 1976.Google Scholar
- Viadana, E.; Bross, I. D. J.; and Pickren, J. W. Cascade spread of blood- borne metastases in solid and non-solid cancers of man. In Pulmonary Metastasis, ed. L. Weiss and H. A. Gilbert. Boston: G.K. Hall & Co., 1978.Google Scholar