Surgical Therapy of Brain Metastases
Part of the
Metastasis: A Monograph Series
book series (METS, volume 2)
Metastatic brain disease is probably the most common central nervous system complication of systemic cancer and is not a problem which lends itself to easy or simplistic answers. The treatment modalities avail-able include surgical excision, radiation therapy, and chemotherapy as well as combinations of all three methods. With very rare exceptions, surgery is restricted to those patients with single intracranial metastases whereas radiation therapy and chemotherapy are applicable to patients with multiple intracranial tumors.
KeywordsCorticosteroid Radionuclide Decadron Methotrexate Cyclophosphamide
Dische, S. et al. Clinical testing of the radiosensitizer RO-07-0582. Experience with multiple doses. Br. J. Cancer
35: 567–579, 1977.PubMedCrossRefGoogle Scholar
Lang, E. J., and Slater, J. Metastatic brain tumors: results of surgical and nonsurgical treatment. Surg. Clin. North Am.
44: 865–872, 1964.PubMedGoogle Scholar
Lieberman, A. et al. Use of high dose corticosteroids in patients with inoperable brain tumors. J. Neurol. Neurosurg. Psych.
40: 678–682, 1977.CrossRefGoogle Scholar
Posner, J. B. Diagnosis and treatment of metastases to the brain. Clin. Bull.
4: 47–57, 1974.PubMedGoogle Scholar
Raskind, R. et al. Survival after surgical excision of single metastatic brain tumors. Am. J. Roentgenol.
111: 323–328, 1971.Google Scholar
Renaudin, J. et al. Dose dependency of Decadron in patients with partially excised brain tumors. J. Neurosurg.
39: 302–305, 1973.PubMedCrossRefGoogle Scholar
Richards, R, and McKissock, W. Intracranial metastases. Br. Med. J.
1: 15–18, 1963.PubMedCrossRefGoogle Scholar
Stortebecker, T. R Metastatic tumors of the brain from a neurosurgical point of view: a follow-up study of 158 cases. J. Neurosurg.
11: 84–111, 1954.PubMedCrossRefGoogle Scholar
Urtasun, R. C. et al. Metronidazole as a radiosensitizer. N. Engl. J. Med.
295: 901–902, 1976.CrossRefGoogle Scholar
Vieth, R. G., and Odom, G. L. Intracranial metastases and their neurosurgical treatment. J. Neurosurg.
23: 375–383, 1965.PubMedCrossRefGoogle Scholar