Analysis of the Benefit of Palliation of Brain Metastases

  • Stanley E. Order
Part of the Metastasis: A Monograph Series book series (METS, volume 2)


The presentation of brain metastasis may occur in a variety of circumstances: a manifestation of progressively disseminated disease with headache or neurologic dysfunction; the concomitant presentation of brain metastasis and a primary lesion (often lung cancer); as a first sign of dissemination after a period of time with no evidence of disease. Regardless of these or other circumstances, the patient most often realizes the prognostic significance of such a finding. Analysis of the benefit of possible palliative treatment requires consideration of all of the issues. The patient, family, and physician have a direct role in decision making and each requires review. In addition, in a larger sense society plays an indirect role in the services and modalities available for patients both with potential cerebral metastasis as well as with active disease.


Brain Metastasis Radiation Pneumonitis Bronchogenic Carcinoma Cranial Metastasis Cell Bronchogenic Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bedikian, A. Y. et al. Glycerol: a successful alternative to dexamethasone for patients receiving brain irradiation for metastatic disease. Cancer Treat. Rep. 62: 1081–1083, 1978.PubMedGoogle Scholar
  2. Bunn, P. A., Jr. et al. Advances in small cell bronchogenic carcinoma. Cancer Treat. Rep. 61: 333–342, 1977.PubMedGoogle Scholar
  3. Chu, F. C. H., and Hilaris, B. B. Value of radiation therapy in the management of intracranial metastasis. CA 14: 577–581, 1961.Google Scholar
  4. Hendrickson, F. R. Radiation therapy of metastatic tumors. Semin. Oncol. 2: 43–46, 1975.PubMedGoogle Scholar
  5. Hendrickson, F. R. The optimum schedule for palliative radiotherapy for metastatic brain cancer. Int. J. Rad. Oncol. Bio. Phys. 2: 165–168, 1977.CrossRefGoogle Scholar
  6. Hendrickson, F., and Gelber, R. Radiation Therapy Oncology Group. Brain Metastasis Report (1978).Google Scholar
  7. Horton, J.; Baxter, D.; and Olson, K. The management of metastasis to the brain by irradiation and corticosteroids. Am. J. Roentgenol. 111: 334–336, 1971.Google Scholar
  8. Hustu, H. O. et al. Prevention of central nervous leukemia by irradiation. CA 32: 585–596, 1973.Google Scholar
  9. Lang, E. F., and Slater, J. Metastatic brain tumors: results of surgical and nonsurgical treatment. Surg. Clin. North Am. 44: 865–872, 1964.PubMedGoogle Scholar
  10. Order, S. E. et al. Improvement in the quality of survival following whole brain irradiation for brain metastasis. Radiology 94: 149–153, 1968.Google Scholar
  11. Prato, F. S. et al. The incidence of radiation pneumonitis as a result of single fraction upper half body irradiation. CA 39: 71–78, 1976.Google Scholar
  12. Shehata, W. M.; Hendrickson, F. R.; and Hindo, W. A. Rapid fractionation technique and retreatment of brain metastasis by irradiation. CA 34: 257–261, 1974.Google Scholar
  13. Stortebecker, T. P. Metastatic tumors of the brain from a neurosurgical point of view: follow up study of 158 cases. J. Neurosurg. 11: 84–111, 1954.PubMedCrossRefGoogle Scholar
  14. Stortebecker, T. P. Metastatic tumors of the brain from a neurosurgical point of view: follow up study of 158 cases. J. Neurosurg. 11: 84–111, 1954.PubMedCrossRefGoogle Scholar

Copyright information

© G.K. Hall & Co. 1980

Authors and Affiliations

  • Stanley E. Order

There are no affiliations available

Personalised recommendations