Abstract
The slope of the sarcomere length-tension relation in cardiac papillary muscle suggests length-dependent activation of the contractile system (1). However, there are no data on the effect of inotropic interventions on this curve. Only muscle length-tension curves are available, which give conflicting results (1,2,3). The purpose of the present study was to examine the effect of varied calcium concentrations on the sarcomere length-tension relationship, using laser diffraction techniques.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Jewell BR: A reexamination of the influence of muscle length on myocardial performance. Circ Res 40:221–230, 1977.
Huntsman LL, Stewart DK: Length dependent calcium inotropism in cat papillary muscle. Circ Res 40:366–371, 1977.
Sonnenblick EH: Force-velocity relations in mammalian heart muscle. Am J Physiol 202:931–939, 1962.
Keurs HEDJ ter: Tension development and sarcomere length in rat heart muscle. In: 7th European congress of cardiology: abstract, vol 1, Amsterdam, 1976, p 57.
Goodman JW: Introduction to Fourier optics, New York, McGraw-Hill, 1968.
Allen DG, Jewell BR, Murray JW: The contribution of activation processes to the lengthtension relation of cardiac muscle. Nature 248:606, 1977.
Forester GV, Mainwood GW: Interval dependent inotropic effects in rat myocardium and the effect of calcium. Pflügers Arch 352:189–196, 1974.
Pollack GH, Krueger JW: Sarcomere dynamics in intact cardiac muscle. Eur J Cardiol 4:53–65, 1976.
Brady AJ: Active stale in cardiac muscle. Physiol Rev 48:570–600, 1968.
Julian FJ, Sollins MR, Moss RL: Absence of a plateau in length-tension relationship of rabbit papillary muscle when internal shortening is prevented. Nature 260:340–342,1976.
Brutsaert DL, Sonnenblick EH: Force-velocity-Iength-time relations of the contractile elements in heart muscle of the cat. Circ Res 14:137–149, 1969.
Fabiato A, Fabiato F: Dependence of the contractile activation of skinned cardiac cells on the sarcomere length. Nature 256:54–56, 1975.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Martinus Nijhoff Publishers bv, The Hague, Boston, London
About this chapter
Cite this chapter
Ter Keurs, H.E.D.J., Rijnsburger, W.H., Van Heuningen, R., Nagelsmit, M.J. (1980). Tension Development and Sarcomere Length in Rat Cardiac Trabeculae: Evidence of Length-Dependent Activation. In: Baan, J., Arntzenius, A.C., Yellin, E.L. (eds) Cardiac Dynamics. Developments in Cardiovascular Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8796-8_3
Download citation
DOI: https://doi.org/10.1007/978-94-009-8796-8_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8798-2
Online ISBN: 978-94-009-8796-8
eBook Packages: Springer Book Archive