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The Oxygen Metabolism of Human Blood Monocytes and Neutrophils

  • Chapter
Mononuclear Phagocytes

Abstract

The monocytes and neutrophilic granulocytes in the mammalian circulation share a number of functional properties. Both cell types are able to move into the tissues to reach the site of an infection and to bind and ingest foreign material. Both cell types can also kill living microorganisms intracellularly and neoplastic cells and erythrocytes extracellularly. On the other hand, there are also distinct functional differences between these cells. Monocytes cooperate with lymphocytes in immuno-logical reactions, playing both an afferent (antigen-processing) and an efferent role (activation by lymphokines). Neutrophils are only involved in this process to the extent that these cells, like monocytes, ingest material opsonized by lymphocytic products. Monocytes also have greater synthetic and digestive capacities than do neutrophils. A number of these characteristics are shown in Table 1. In general, neutrophils are shortlived highly efficient killer cells, whereas monocytes are multifunctional cells that may develop into tissue macrophages with specialized functions.

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Authors
  1. D. Roos
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  2. Joke S. van der Stijl-Neijenhuis
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  3. S. J. Klebanoff
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  4. D. Roos
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Editors and Affiliations

  1. Department of Infectious Diseases, University Hospital, Leiden, The Netherlands

    Ralph van Furth

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© 1980 Springer Science+Business Media Dordrecht

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Roos, D., van der Stijl-Neijenhuis, J.S., Klebanoff, S.J., Roos, D. (1980). The Oxygen Metabolism of Human Blood Monocytes and Neutrophils. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8793-7_47

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  • DOI: https://doi.org/10.1007/978-94-009-8793-7_47

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8795-1

  • Online ISBN: 978-94-009-8793-7

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