Determinants of Phagosome-Lysosome Fusion in Mouse Macrophages
Membrane fusion is an important event in many cell activities. It occurs between cells themselves, as in fertiliziation, myo-blast fusion, and virus or polyethylene glycol-induced cell-cell fusion. Some viruses fuse with cells to infect them, and many bud from the cell membrane during replication, requiring fusion to complete their maturation. Membranes fuse to close endocytic vesicles of various sizes and to separate two daughter cells during cytokinesis. Secreting cells fuse exocytic vesicles with their plasma membrane. Phagosomes fuse with lysosomes to begin the process of intracellular digestion. Little is known about these physiological fusion processes. Most work has been done in several model systems, which perhaps give some hints about possible molecular mechanisms.
KeywordsCholesterol Bacillus Luminal Ferritin Biotin
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