Skip to main content
SpringerLink
Log in

The Locomotor Behaviour of Human Blood Monocytes in Chemotactic and Chemokinetic Environments and the Role of Substratum in Monocyte Locomotion

  • Chapter
Mononuclear Phagocytes

Abstract

Mononuclear phagocytes from a variety of sources, for example, blood monocytes, macrophages from peritoneal exudates or from the unstimulated peritoneal cavity, and alveolar macrophages, all show locomotor reactions to chemoattractants. In this paper we deal chiefly with blood monocytes. Although the role of macrophage chemotaxis in the evolution of inflammatory lesions is uncertain, it does at least seem probable that the monocytes which leave the blood are in the first instance directed into such lesions by chemotactic stimuli.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allan, R.B. & P.C. Wilkinson (1978) A visual analysis of chemotactic and chemokinetic locomotion of human neutrophil leucocytes. Experimental Cell Research 111, 191.

    Article  PubMed  CAS  Google Scholar 

  • Bumol, T.F. & S.D. Douglas (1977) Human monocyte cytoplasmic spreading in vitro: Early kinetics and scanning electron microscopy. Cellular Immunology 34, 70.

    Article  PubMed  CAS  Google Scholar 

  • Carrel, A. & A.H. Ebeling (1926) The fundamental properties of the fibro-blast and the macrophage. II. The macrophage. Journal of Experimental Medicine 44, 285.

    Article  PubMed  CAS  Google Scholar 

  • Carter, S.B. (1965) Principles of cell movement: the direction of cell movement and cancer invasion. Nature 208, 1183.

    Article  PubMed  CAS  Google Scholar 

  • Carter, S.B. (1967) Haptotaxis and the mechanism of cell motility. Nature 213, 256.

    Article  PubMed  CAS  Google Scholar 

  • Dierich, M.P., Wilhelmi, D. & G. Till (1977) Essential role of surface bound chemoattractant in leukocyte migration. Nature 270, 351.

    Article  PubMed  CAS  Google Scholar 

  • Dixon, H.M. & M. McCutcheon (1935) Absence of chemotropism in lymphocytes. Archives of Pathology 19, 679.

    CAS  Google Scholar 

  • Fraenkel, G.S. & D.L. Gunn (1961) The orientation of animals; Kineses, taxes and compass reactions. Dover, New York.

    Google Scholar 

  • Gail, M.H. & C.W. Boone (1970) The locomotion of mouse fibroblasts in tissue culture. Biophysical Journal 10, 980.

    Article  PubMed  CAS  Google Scholar 

  • Griffin, F.M., Griffin, J.A., Leider, J.E. & S.C. Silverstein (1975) Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane. Journal of Experimental Medicine 142, 1263.

    Article  PubMed  Google Scholar 

  • Griffin, F.M., Griffin, J.A., & S.C. Silverstein (1976) Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone-marrow-derived lymphocytes. Journal of Experimental Medicine 144, 788.

    Article  PubMed  Google Scholar 

  • Harris, H. (1953) Chemotaxis of monocytes. British Journal of Experimental Pathology 34, 276.

    PubMed  CAS  Google Scholar 

  • Henney, C.S. & K. Ishizaka (1968) Antigenic determinants specific for aggregated yG-globulin. Journal of Immunology 100, 718.

    CAS  Google Scholar 

  • Keller, H.U., Wilkinson, P.C., Abercrombie, M., Becker, E.L., Hirsch, J.G., Miller, M.E., Ramsey, W.S. & S.H. Zigmond (1977a) A proposal for the definition of terms related to locomotion of leucocytes and other cells. Clinical and Experimental Immunology 27, 377.

    PubMed  CAS  Google Scholar 

  • Keller, H.U., Wissler, J.H., Hess, M.W. & H. Cottier (1977b) Relation between stimulus intensity and neutrophil chemotactic response. Experientia 33, 534.

    Article  PubMed  CAS  Google Scholar 

  • Keller, H.U., Wissler, J.H., Hess, M.W. & H. Cottier (1978) Distinct chemo-kinetic and chemotactic responses in neutrophil granulocytes. European Journal of Immunology 8, 1.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, W.H. (1934) On the locomotion of the polymorphonuclear neutrophils of the rat in autoplasma cultures. Bulletin of the Johns Hopkins Hospital 55, 273.

    Google Scholar 

  • Lewis, W.H. (1939) The role of a superficial plasmagel layer in changes of form, locomotion and division of cells in tissue cultures. Archiv für Experimentelle Zellforschung 23, 1.

    Google Scholar 

  • McCutcheon, M. (1946) Chemotaxis in leukocytes. Physiological Reviews 26, 319.

    PubMed  CAS  Google Scholar 

  • Nossal, R. & S.H. Zigmond (1976) Chemotropism indices for polymorphonuclear leukocytes Journal 16, 1171.

    CAS  Google Scholar 

  • Ramsey, W.S. (1972) Locomotion of human polymorphonuclear leucocytes. Experimental Cell Research 72, 489.

    Article  PubMed  CAS  Google Scholar 

  • Robineaux, R. (1964) Movements of cells involved in inflammation and immunity. In: R.D. Allen & N. Kamiya (eds) Primitive Motile Systems in Cell Biology, p. 351. Academic Press, New York.

    Chapter  Google Scholar 

  • Rothert, W. (1901) Beobachtungen und Betrachtungen über taktische Reiz-erscheinüngen. Flora 88, 371.

    Google Scholar 

  • Rydgren, L., Norberg, B., Svensson, B. & G. Simmingskoeld (1978) The phagocytosis associated chemotaxis of human mononuclear leucocytes from peripheral blood is not antitubulin-sensitive. Scandinavian Journal of Immunology 7, 251.

    Article  PubMed  CAS  Google Scholar 

  • Senda, N., Tamura, H., Shibata, N., Yoshitake, J., Kondo, K. & K. Tanaka (1975) The mechanism of the movement of leucocytes. Experimental Cell Research 91, 393.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, P.C. (1973) Recognition of protein structure in leukocyte chemotaxis. Nature 244, 512.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, P.C. (1976) A requirement for albumin as carrier for low molecular weight leukocyte chemotactic factors. Experimental Cell Research 103, 415.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, P.C. & R.B. Allan (1978a) Assay systems for measuring leukocyte locomotion: an overview. In: J.I. Gallin & P.G. Quie (eds) Leukocyte chemotaxis, p. 1–24. Raven Press, New York.

    Google Scholar 

  • Wilkinson, P.C. & R.B. Allan (1978b) Chemotaxis of neutrophil leukocytes towards substratum-bound protein attractants. Experimental Cell Research, 117, 403.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, P.C. & I.C. McKay (1974) Recognition in leucocyte chemotaxis. Studies with structurally modified proteins. Antibiotics and chemotherapy 19, 421.

    PubMed  CAS  Google Scholar 

  • Wilkinson, P.C., Parrott, D.M.V., Russell, R.J. & F. Sless (1977) Antigen-induced locomotor responses in lymphocytes. Journal of Experimental Medicine 145, 1158.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S.H. (1977) Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. Journal of Cell Biology 75, 606.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S.H. (1978) Chemotaxis by polymorphonuclear leukocytes. Journal of Cell Biology 77, 269.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S.H. & J.G. Hirsch (1973) Leukocyte locomotion and chemotaxis. New methods for evaluation and demonstration of cell-derived chemotactic factor. Journal of Experimental Medicine 137, 387.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. C. Wilkinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. B. Allan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Blussé van Oud Alblas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Infectious Diseases, University Hospital, Leiden, The Netherlands

    Ralph van Furth

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Wilkinson, P.C., Allan, R.B., van Oud Alblas, A.B. (1980). The Locomotor Behaviour of Human Blood Monocytes in Chemotactic and Chemokinetic Environments and the Role of Substratum in Monocyte Locomotion. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8793-7_18

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-8793-7_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8795-1

  • Online ISBN: 978-94-009-8793-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation