Abstract
Thirty-one patients (58 eyes) with either primary open angle glaucoma (19 patients with 34 eyes) or suspected glaucoma (12 patients with 24 eyes) were treated for a period of 7 months with only guanethidine 1% and epinephrine 0.2% in one eyedrop (GA-weak) twice daily. The intraocular pressure (IOP) was controlled in 64% of all eyes with an average pressure decrease of 8.4 mm Hg or 31% (p < 0.005). Tonography revealed that the decrease in IOP was due both to inhibition of aqueous humour production (26%, p < 0.005) and to an increase in outflow facility (32%, p < 0.005), showing supersensitivity to inflow and outflow for epinephrine 0.2%. 8 patients were eliminated from the study due to tolerance for the drug.
The side-effects were mild and did not lead to cessation of treatment. GA-weak was found to be an effective agent in the management of glaucoma. The treatment was well tolerated by the patients.
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© 1981 Dr. W. Junk by Publishers, The Hague, The Nertherlands
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Hoyng, P.F.J., Dake, C.L. (1981). The Combination of Guanethidine 1% and Epinephrine 0.2% in One Eye Drop (Ga-Weak) In the Treatment of Glaucoma. In: Pharmacological Denervation and Glaucoma. Monographs in Ophthalmology 2, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8674-9_14
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DOI: https://doi.org/10.1007/978-94-009-8674-9_14
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