Abstract
Misrouting of retinogeniculostriate projections associated with retinal hypopigmentation has been found to be a general phenomenon throughout mammals, including humans. The distinctive finding when testing human albinos is the dramatic change in the VEP between hemispheres when effects of binocular stimulation are compared with monocular stimulation. We have compared the efficacy of luminance and pattern onset/offset, noise modulated light, pattern reversal, and pattern appearance/disappearance stimuli in detecting misrouted optic fibers. Pattern appearance/disappearance were found superior to other stimuli at detecting anomalies of misrouting of retinogeniculostriate projections. As a group, humans with retinal hypopigmentation have poor VEPs to disappearance or pattern reversal stimuli. Acuity and nystagmus seem to be the two variables most indicative of poor pattern reversal responses. Appearance/disappearance (onset/offset) pattern stimuli are more versatile for detection of abnormalities in the visual system than pattern reversal stimuli.
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© 1981 Dr W. Junk Publishers
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Creel, D., Spekreijse, H., Reits, D. (1981). Visual Evoked Potential (VEP) Methods of Detecting Misrouted Optic Projections. In: Spekreijse, H., Apkarian, P.A. (eds) Visual Pathways. Documenta Ophthalmologica Proceedings Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8656-5_16
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DOI: https://doi.org/10.1007/978-94-009-8656-5_16
Publisher Name: Springer, Dordrecht
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