Origin of Life pp 487-493 | Cite as

Search for Primitive Replicative Properties on Early Polypeptides

  • André Brack
  • Gérard Spach
Conference paper


The sequences of polypeptide chains which are built up with alternating hydrophilic-hydrophobic residues concentrate them-selves in the β-pleated sheet conformation when dissolved in salted water. The sheets are more stable than the α-helix and are shown to constitute a pathway to the enrichment in one enantiomer. They are considered as a single system with potential template activity.


Random Coil Isobutyric Acid Activate Amino Acid Template Activity Amino Isobutyric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. ().
    (1) Lohrmann, R., Orgel, L.E., Nature 261, 342 (1976)CrossRefGoogle Scholar
  2. (2).
    Nelsestuen, G.L., J. Holec. Evol. 15, 59 (1980)CrossRefGoogle Scholar
  3. (3).
    Cairns-Smith, A.G., The life puzzle. Edinburgh: Oliver and Boyd (1971)Google Scholar
  4. (4).
    Brack, A., Orgel, L.E., Nature 256, 383 (1975)CrossRefGoogle Scholar
  5. (5).
    Brack, A., BioSystems 9, 99 (1977)CrossRefGoogle Scholar
  6. (6).
    Brack, A., Caille, A., Int. J. Peptide Protein Res. 11, 128 (1978)CrossRefGoogle Scholar
  7. (7).
    Brack, A., Spach, G., J. Nolec. Evol. 13, 35 (1979)CrossRefGoogle Scholar
  8. (8).
    Brack, A., Spach, G., J. Nolec. Evol., in press (1980)Google Scholar
  9. (9).
    Spach, G., Brack, A., J. Nolec. Evol. 13, 47 (1979)CrossRefGoogle Scholar

Copyright information

© D. Reidel Publishing Company 1981

Authors and Affiliations

  • André Brack
    • 1
  • Gérard Spach
    • 1
  1. 1.Centre de Biophysique Moléculaire, CNRSOrléansFrance

Personalised recommendations