Abstract
With enteral antigen application it is possible to manipulate the Local immune response in animals. The aim of the experimental investigations was to test the influence of enterally applied antigen on a systemic immune response. Immunised rabbits were fed with the antigen and afterwards i.v. challenged with the antigen. Circulatory disorders Like blood pressure decrease or blood flow reduction after challenge was markedly improved by antigen feeding. An explanation for this observed phenomenon is a significant reduction of circulating antibodies during the absorption of the antigen. The reduction of antibodies is due to a fixation within the Layers of the gut and an elimination into the lumen. These mechanisms are probably also involved in a successful desensitisation in allergic patients.
Supported by a grant from Deutsche Forschungsgemeinschaft.
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© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
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Seifert, J., Eberle, T., Hallfeld, K., Enders, G., Brendel, W. (1981). Changes of Systemic Hypersensitivity Due to Enterally Applied Antigen. In: Bourne, F.J. (eds) The Mucosal Immune System. Current Topics in Veterinary Medicine and Animal Science, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8331-1_29
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DOI: https://doi.org/10.1007/978-94-009-8331-1_29
Publisher Name: Springer, Dordrecht
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