Mucosal Immunity

  • J. Bienenstock
  • A. D. Befus
  • M. McDermott
Part of the Current Topics in Veterinary Medicine and Animal Science book series (CTVM, volume 12)


In the last two decades considerable attention has been focussed on immune mechanisms of mucosal tissues. Perhaps this is not surprising since mucosal surfaces are intimately associated with potentially pathogenic organisms and continuous antigenic bombardment with products of the environment and dietary antigens. Because of the size of the subject, we will only discuss selected components of the mucosal immune system and will focus on the intestine since more is known about this organ in respect to mucosal immunity. For a more extensive treatment, readers are referred elsewhere (Tomasi and Bienenstock, 1968; Tomasi and Grey, 1972; Heremans, 1974; Ciba Symposium 46, 1977; Asquith, 1979; Bienenstock and Befus, 1980).


Mucosal Immune System Secretory Component Oral Immunization Mucosal Site Intestinal Lamina Propria 
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  1. Abraham, R., Fabian, R.J., Goldberg, L. and Coulston, F., 1974. Role of lysosomes in carrageenian-induced cecal ulceration. Gastroenterology 67, 1169.PubMedGoogle Scholar
  2. Abrahamson, D.R., Powers, A. and Rodewald, R., 1979. Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young. Science 206, 657.CrossRefGoogle Scholar
  3. Amsden, A., Ewan, V., Yoshida, T. and Cohen, S., 1978. Studies on cellular receptors for lymphokines. I. Interaction of chemotactic factors with monosaccharides. J. Immunol. 120, 542.PubMedGoogle Scholar
  4. André, C., Heremans, J.F., Vaerman, J.P. and Cambiaso, C.L., 1975. A mechanism for the induction of immunologica tolerance by antigen feeding: antigen-antibody complexes. J. Exp. Med. 142, 1509.PubMedCrossRefGoogle Scholar
  5. Arnaud-Battandier, F., Bundy, B.M., O’Neill, M.,Bienenstock, J. and Nelson, D.L., 1978. Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs. J. Immunol. 121, 1059.Google Scholar
  6. Asherson, G.L., Zembela, M., Perera, M., Mayhew, B. and Thomas, W.R., 1977. Production of immunity and unresponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer’s patches, mesenteric lymph nodes and other lymphoid tissues. Cell Immunol. 33, 145.PubMedCrossRefGoogle Scholar
  7. Asquith, P., 1979. Immunology of the Gastrointestinal Tract. Churchill Livingston, London. 348 ppGoogle Scholar
  8. Baba T., Yoshida, T., Yoshida, T. and Cohen, S., 1979. Suppression of cell-mediated immune reactions by monosaccharides. J. Immunol., 122, 838.PubMedGoogle Scholar
  9. Bienenstock, J., 1974. The physiology of the local immune response and the gastrointestinal tract. In: Progress in Immunology II. vol. 4. (eds. L. Brent & J. Holborow ). North-Holland Publishing. p 197.Google Scholar
  10. Bienenstock, J.and Befus, A.D., 1980. Mucosal immunology. Immunology (in press)Google Scholar
  11. Bienenstock, J., Clancy, R.L. and Perey, D.Y.E., 1976. Bronchus associated lymphoid tissue (BALI): its relationship to mucosal immunity. In: Immunologic and Infectious Reactions in the Lung (eds. C.H. Kirkpatrick and H.Y. Reynolds ). Marcel Dekker Inc., New York. p 29.Google Scholar
  12. Bienenstock, J., Johnston, N. and Perey, D.Y.E., 1973a. Bronchial lymphoid tissue. I. Morphologic characteristics. Lab. Invest. 28, 686.Google Scholar
  13. Bienenstock, J., Johnston, N. and Perey, D.Y.E., 1973b. Bronchial lymphoid tissue. II. Functional characteristics. Lab. Invest. 28, 693.Google Scholar
  14. Bienenstock, J. and Poortmans, J., 1970. γA in exercise proteinuria. Proc. Soc. Exp. Biol. Med. 134, 138.PubMedGoogle Scholar
  15. Bounous, G. and Kongshavn, P.A.L., 1978. The effect of dietary amino acids on immune reactivity. Immunology 35, 257.PubMedGoogle Scholar
  16. Challacombe, S., Krco, C.J., David, C.S. and Tomasi, T.B., 1980. Defective antigen presentation by adherent Ia positive Peyer’s patch cells. (submitted for publication )Google Scholar
  17. Chandra, R.K., 1980. Mucosal immunity in nutritional deficiency. In: Mucosal Immune System in Health and Disease. Proceedings of the 81st Ross Conference on Pediatric Research. (In press)Google Scholar
  18. Ciba Foundation Symposium 46, 1977. Immunology of the Gut (eds. R. Porter and J. Knight). Elsevier, Excerpta Medica, Amsterdam.Google Scholar
  19. Clancy, R.L., and Pucci, A., 1978. Absence of K cells in human gut mucosa. Gut 19, 273Google Scholar
  20. Coelho, I.M., Pereira, M.T. and Virella, G., 1974. Analytical study of salivary immunoglobulins in multiple myeloma. Clin. Exp. Immunol. 17, 417.PubMedGoogle Scholar
  21. Cook, P.M. and Olson, G.F., 1979. Ingested mineral fibers: elimination in human urine. Science 204, 194.CrossRefGoogle Scholar
  22. Colten, H.R. and Bienenstock, J., 1974. Lack of C3 activation through classical or alternate pathways by human secretory IgA anti blood group A antibody. In: The Immunologlobulin A System (eds. J. Mestecky and A.R. Lawton ). Plenum Publishing, New York. p 305.Google Scholar
  23. Cook, P.M. and Olson, G.F., 1979. Ingested mineral fibers: elimination in human urine. Science 204, 194.CrossRefGoogle Scholar
  24. Craig, S.,W. and Cebra, J.J., 1971. Peyer’s patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. J. Exp. Med. 134, 188.Google Scholar
  25. Darlington, D. and Rogers, A.W., 1966. Epithelial lymphocytes in the small intestine of the mouse. J. Anat. 100, 813.PubMedGoogle Scholar
  26. Fazekas de St. Groth and Donnelly, M., 1950. Studies in experimental immunology of influenza: enhancement of immunity by pathotopic vaccination. Austr. J. Exp. Biol. 28, 77.Google Scholar
  27. Ferguson, A., 1977. Intraepithelial lymphocytes of the small intestine. Gut 18, 921.PubMedCrossRefGoogle Scholar
  28. Ferguson, A. and Macdonald, T.T., 1977. Effects of local delayed hypersensitivity on the small intestine. In: Immunology of the Gut. Elsevier North-Holland. p 305.Google Scholar
  29. Fiocchi, C., Battisto, J.R. and Farmer, R.G., 1979. Gut mucosal lymphocytes in inflammatory bowel disease: isolation and preliminary functional characteristics. Dig. Dis. Sci. 24, 705.CrossRefGoogle Scholar
  30. Fraker, P.J., Depasquale-Jardieu, P., Zwickl, C.M. and Luecke, R.W., 1978. Regeneration of T-cell helper function in zinc-deficient adult mice. Proc. Natl. Acad. Sci. 75, 5660.CrossRefGoogle Scholar
  31. Gearhard, P.J. and Cebra, J.J., 1979. Differentiated B lymphocytes: potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load. J. Exp. Med. 149, 216.Google Scholar
  32. Goodacre, R., Davidson, R., Singal, D. and Bienenstock, J., 1979.Google Scholar
  33. Gerbrandy, J.L.F. and Bienenstock, J., 1976. Kinetics and localization of IgE tetanus antibody response in mice immunized by the intratracheal, intraperitoneal and subcutaneous routes. Immunology 31, 913.PubMedGoogle Scholar
  34. Goldblum, R.M., Ahlstedt, S., Carlsson, B., Hanson, L.A., Jodal, V., Lidin-Janson, G. and Sohl-Åkerlund, A., 1975. Antibody-forming cells in human colostrum after oral immunization. ‘Nature 257, 797.Google Scholar
  35. Goodacre, R., Davidson, R., Singal, D. and Bienenstock, J., 1979.Google Scholar
  36. Morphologic and functional characteristics of human intestinal lymphoid cells isolated by a mechanical technique. Gastroenterology 76, 300.Google Scholar
  37. Gowans, J.L. and Knight, E.J., 1964. The route of re-circulation of lymphocytes in the rat. Proc. Roy. Soc. Ser. B. Biol. Sci., 159, 257.CrossRefGoogle Scholar
  38. Guy-Grand, D., Griscelli, C. and Vassali, P., 1978. The mouse gut T lymphocyte, a novel type of T cell. Nature, origin and traffic in mice in normal and graft-versus-host conditions. J. Exp. Med. 148, 1661.PubMedCrossRefGoogle Scholar
  39. Guy-Grand, D., Griscelli, C. and Vassalli, P., 1974. The gut-associated lymphoid system: nature and properties of the large dividing cells. Eur. J. Immunol. 4, 435.PubMedCrossRefGoogle Scholar
  40. Hall, J.G. and Smith, M.E., 1970. Homing of lymph-borne immunoblasts to the gut. Nature 226, 262.PubMedCrossRefGoogle Scholar
  41. Halsey, J.F., Johnson, B.H. and Cebra, J.J., Cebra. Transport of immunoglobulins from serum into colostrum. J. Exp. Med. 151, 767.Google Scholar
  42. Halsey, J.R. and Benjamin, D.C., 1976. Induction of immunologic tolerance in bursing neonates by absorption of tolerogen from colostrum. J. Immunol. 116, 1204.PubMedGoogle Scholar
  43. Ham, A.W., 1969. In: Histology by A.W. Ham. Lippincott Co., Philadelphia. p 313.Google Scholar
  44. Hanson, D.G., Vaz, N.M., Rawlings, L.A. and Lynch, J.M., 1979. Inhibition Hanson, D.G., Vaz, N.M., Rawlings, L.A. and Lynch, J.M., 1979. Inhibition of specific immune responses by feeding protein antigens. H. Effects of prior passive and active immunization. J. Immunol. 122, 2261.PubMedGoogle Scholar
  45. Harris, J.G., Dupont, H.L. and Hornick, R.B., 1972. Fecal leukocytes in diarrheal illness. Ann. Intern. Med. 76, 697.PubMedGoogle Scholar
  46. Heatley, R.V. and Bienenstock, J., 1980. Lymphocytes in the lumen of the rabbit. appendix. (Submitted for publication)Google Scholar
  47. Heremans, J.G., 1974. Immunoglobulin A. In: The Antigens vol. II.(ed. M. Sela). Academic Press, New York. p 365Google Scholar
  48. Hoerlein, A.B., 1957. The influence of colostrum on antibody response in baby pigs. J. Immunol. 78, 112.PubMedGoogle Scholar
  49. Jacobson, L.O., Marks, E.K., Simmons, E.L. and Gaston, E.O., 1961. Immune response in irradiated mice with Peyer’s patch shielding. Proc. Soc. Exp. Biol. Med. 108, 487.PubMedGoogle Scholar
  50. Jarrett, E.E.E. and Hall, E., 1979. Selective suppression of IgE antibody responsiveness by maternal influence. Nature 280, 145.PubMedCrossRefGoogle Scholar
  51. Kagnoff, M.F., 1978. Effects of antigen-feeding on intestinal and systemic immune responses. I. Priming of precursor cytotoxic T cells by antigen feeding. J. Immunol. 120, 395.Google Scholar
  52. Kagnoff, M.F. and Campbell, S., 1974. Functional characteristics of Peyer’s patch lymphoid cells. I. Induction of humoral antibody and cell mediated allograft reactions. J. Exp. Med. 139, 398.PubMedCrossRefGoogle Scholar
  53. Keren, D.F., Holt, P.S., Collins, H.H., Gemski, P. and Formal, S.B., 1978. The role of Peyer’s patches in the local immune response of rabbit ileum to live bacteria. J. Immunol. 120, 1892.PubMedGoogle Scholar
  54. Kiyono, H., McGhee, J.R., and Michalek, S.M., 1980. Lipopolysaccharide regulation of the immune response: comparison of responses to LPS in germfree Escherichia Coli - monoassociated and conventional mice. J. Immunol. 124, 36.PubMedGoogle Scholar
  55. Lawton, A.R., R., R. and Mage, R.G., 1970. Synthesis of secretory IgA in the rabbit. 3. Interaction of colostral IgA fragments with T chain. J. Immunol. 104, 397.Google Scholar
  56. Lemaitre-Coelho, I., Jackson, G.D.F. and Vaerman, J.P., 1978. High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction. J. Exp. Med. 147, 934.CrossRefGoogle Scholar
  57. Macpherson, G.G. and Steer, H.W., 1979. Properties of mononuclear phagocytes derived from the small intestinal wall of rats. In: Function and Structure of the Immune System (eds. W. MullerBucholtz and H.K. Muller-Hermelink ). Plenum Press, New York. p 433.Google Scholar
  58. Marsh, M.N., 1975. Studies of intestinal lymphoid tissue. I. Electron microscopic evidence of ‘blast transformation’ in epithelial lymphocytes of mouse small intestinal mucosa. Gut 16, 665.Google Scholar
  59. Matthew, D.J., Taylor, B., Norman, A.P., Turner, M.W. and Soothill, J.F., 1977. Prevention of Eczema. Lancet 1, 321.PubMedCrossRefGoogle Scholar
  60. Mattingly, J.A., Eardley, D.D., Kemp, J.D. and Gershon, R.K., 1979. Induction of suppressor cells in rat spleen: influence of microbial stimulation. J. Immunol. 122, 787.PubMedGoogle Scholar
  61. Mattingly, J.A. and Waksman, B.H., 1978. Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer’s patches after oral administration of sheep erythrocytes and their systemic migration. J. Immunol. 121, 1878.PubMedGoogle Scholar
  62. McDermott, M.R. and Bienenstock, J., 1979. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory and genital tissues. J. Immunol, 122, 1892.PubMedGoogle Scholar
  63. McDermott, M.R., Bienenstock, J., Mark, D.A. and Suskind, R., 1980. Depressed intestinal localization of mucosal lymphoblasts during vitamin A and protein calorie deficiency. (In preparation)Google Scholar
  64. McGhee, J.R., Kiyono, H., Michalek, S.M., Babb, J.L., Rosenstreich, D.L. and Mergenhagen, S.E., 1980. Lipopolysaccharide ( LPS) regulation of the immune response: T lymphocytes from normal mice suppress mitogenic and immunogenic responses to LPS. J. Immunol. 124, 1603.PubMedGoogle Scholar
  65. Mestecky, J., Crago, S.S., Laven, G.T. and McGhee, J.R., 1980. Immunoglobulin-containing cells and non-cellular elements of human colostrum. In: Mucosal Immune System in Health and Disease. Proceedings of the 81st Ross Conference on Pediatric Research (In press)Google Scholar
  66. Miller, H.R.P. and Nawa, Y., 1979. NippostrongyZus brasiliensis: intestinal goblet-cell response in adoptively immunized rats. Exp. Parasit47,81.PubMedCrossRefGoogle Scholar
  67. Montgomery, P.C., Khaleel, S.A., Goudswaard, J. and Virella, G., 1977. Selective transport of an oligomeric IgA into canine saliva. Immunol. Commun. 6, 633.PubMedGoogle Scholar
  68. Mulks, M.H. and Plaut, A.G., 1978. IgA protease production as a characteristic distinguishing pathogenic from harmless neisseriaceae. N. Engl. J. Med. 299, 973.Google Scholar
  69. Nagura H., Brandtzaeg, P., Nakane, P.K. and Brown, W.R., 1979. Ultrastructural localization of J chain in human intestinal mucosa. J. Immunol. 123, 1004.Google Scholar
  70. Ngan, J. and Kind, L.S., 1978. Suppressor T cells for IgE and IgG in Peyer’s patches of mice made tolerant by the oral administration of ovalbumin. J. Immunol. 120, 861.PubMedGoogle Scholar
  71. Orlans, E., Peppard, J., Reynolds, J. and Hall, J., 1978. Rapid active transport of immunoglobulin A from blood to bile. J. Exp. Med. 147, 588.PubMedCrossRefGoogle Scholar
  72. Owen, R.L., 1977. Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology 72, 440.PubMedGoogle Scholar
  73. Owen, R.L., Nenamic, P.C. and Stevens, D.P., 1979. Ultrastructural observations on giardiasis in a murine model. I. Intestinal distribution attachment and relationship to the immune system of Giardia munis. Gastroenterology 76, 757.PubMedGoogle Scholar
  74. Parker, D. and Turk, J.L., 1978. Delay in the development of the allergic response to metals following intratracheal instillation. Int. Arch. Allergy Appl. Immunol., 57, 289.PubMedCrossRefGoogle Scholar
  75. Perey, D.Y.E., Cooper, M.D. and Good. R.A., 1968. The mammalian homologue of the avian bursa. I. Neonatal extirpation of Peyer’s patch-type lymphoepithelial tissues in rabbits. Method and inhibition of development of humoral immunity. Surgery 64, 614.Google Scholar
  76. Perrotto, J.L., Hang, L.M., Isselbacher, K.J. and Warren, K.S., 1974. Systemic cecular hypersensitivity induced by an intestinally absorbed antigen. J. Exp. Med., 140, 296.PubMedCrossRefGoogle Scholar
  77. Pierce, N.J. and Koster, F.T., 1980. Priming and suppression of the intestinal immune response to cholera toxoid-toxin by parenteral toxoid in rats. J. Immunol., 124, 307.PubMedGoogle Scholar
  78. Pittard, W.B. and Bill, K., 1979. Immunoregulation by breast milk cells. Cell Immunol., 42, 437.PubMedCrossRefGoogle Scholar
  79. Rose, M.L., Parrott, D.M.V. and Bruce, R.G., 1976. Migration of lymphoblasts to the small intestine. II. Divergent migration of mesenteric and peripheral immunoblasts to sites of inflammation in the mouse. Cell Immunol. 27, 36.PubMedCrossRefGoogle Scholar
  80. Roux, M.E., McWilliams, M., Lamm, M.E. and Phillips-Quagliata, J.M., 1979. Site of maturation of IgA plasma cell precursors. Fed. Proc., 38, 1081.Google Scholar
  81. Roux, M.E., McWilliams, M., Phillips-Quagliata, J.M., Weisz-Carrington, P. and Lamm, M.E., 1977. Origin of IgA-secreting plasma cells in the mammary gland. J. Exp. Med. 146, 1311.PubMedCrossRefGoogle Scholar
  82. Rudzik, O. and Bienenstock, J., 1974. Isolation and characteristics of gut mucosal lymphocytes. Lab. Invest., 30, 260.Google Scholar
  83. Rudzik, O., Clancy, R.L., Perey, D.Y.E., Day, R.P. and Bienenstock, J., 1975. Repopulation with IgA-containing cells of bronchial and intestinal lamina propria after the transfer of homologous Peyer’s patch and bronchial lymphocytes. J. Immunol., 114, 1599.PubMedGoogle Scholar
  84. Seelig, L.L., Holt, R.G. and Beer, A.E., 1979. Cell kinetics and transepithelial migration of leukocytes in rat mammary epithelium during pregnancy and lactation. In: Immunology of Breast Milk (eds. P.L. Ogra and D. Dayton ). Raven Press, New York. p 159.Google Scholar
  85. Singal, D.P., O’Neill, M., Clancy, R. and Bienenstock, J., 1976.Functional T cells in rabbits gut mucosal lymphocytes. Gut 17, 325.PubMedCrossRefGoogle Scholar
  86. Socken, D.J., Jeejeebhoy, K.N., Bazin, H. and Underdown, B.J., 1979. Identification of secretory component as an IgA receptor on rat hepatocytes. J. Exp. Med. 50, 1538.CrossRefGoogle Scholar
  87. Socken, D.J. and Underdown, B.J., 1978. Comparison of human, bovine and rabbit secretory component-immunoglobulin interactions. Immunochemistry 15, 499.PubMedCrossRefGoogle Scholar
  88. Sprent, J., 1976. Fate of H2-activated T lymphocytes in syngeneic hosts. I. Fate in lymphoid tissue and intestines traced with 3H-thymidine, 125I-Deoxyuridine and 51Chromium. Cell Immunol., 21, 278.PubMedCrossRefGoogle Scholar
  89. Stokes, C.R., Swarbrick, E.T. and Soothill, J.F., 1980. Immune elimination and enhanced antibody responses: functions of circulating IgA Immunology 40, 455.Google Scholar
  90. Swarbrick, E.T., Stokes, C.R. and Soothill, J.F., 1979. Absorption of antigens after oral immunization and the simultaneous induction of specific systemic tolerance. Gut 20, 121.PubMedCrossRefGoogle Scholar
  91. Tada, T. and Ishizaka, K., 1970. Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey. J. Immunol., 104, 377.PubMedGoogle Scholar
  92. Tenner-Racz, K., Racz, P., Myrvik, Q.N., Ockers, J.R. and Geister, R., 1979. Uptake and transport of horseradish peroxidase by lymphoepithelium of the bronchial associated lymphoid tissue in normal and bacillus Calmette-Guérin-immunized and challenged rabbits. Lab. Invest. 41, 106.PubMedGoogle Scholar
  93. Thomas, H.C. and Parrott, D.M.V., 1974. The induction of tolerance to a soluble protein antigen by oral administration. Immunology 27, 631.PubMedGoogle Scholar
  94. Tomasi, T.B. and Bienenstock, J., 1968. Secretory immunoglobulins. In: Advances in Immunology vol. 9. Academic Press, New York. p 1.Google Scholar
  95. Tomasi, T.B. and Grey, H.M., 1972. Structure and function of immunoglobulin A. Progr. Allergy 16, 81.Google Scholar
  96. Underdown, B.J., Knight, A. and Papsin, F.R., 1976. Relative paucity of IgE in human milk. J. Immunol., 116, 1435.PubMedGoogle Scholar
  97. Van Epps, D.E., Reed, K. and Williams, R.C., 1978. Suppression of human PMN bactericidal activity by human IgA paraproteins. Cell Immunol., 36, 363.PubMedCrossRefGoogle Scholar
  98. Walker, W.A. and Isselbacher, K.J., 1977. Intestinal antibodies. N. Engl. J. Med., 297, 767.PubMedCrossRefGoogle Scholar
  99. Weisz-Carrington, P., Roux, M.E., McWilliams, M., Phillips-Quagliata, J.M. and Lamm, M.E., 1979. Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system. J. Immunol., 123, 1705.PubMedGoogle Scholar

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© ECSC, EEC, EAEC, Brussels-Luxembourg 1981

Authors and Affiliations

  • J. Bienenstock
    • 1
  • A. D. Befus
    • 1
  • M. McDermott
    • 1
  1. 1.McMaster University Health Sciences CentreHamiltonCanada

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