Abstract
An immunologic system has evolved whereby newborn animals derive an appreciable degree of protection from enteric infections by means of passive immunity. This report explores some of the facets of this system, using infections of swine with transmissible gastroenteritis virus, rotavirus, or enterovirus as examples. In swine, and probably in most mono gastric animals, passive immunity against enteric infections is dependent on the ingestion — at normal intervals for the particular species — of colostrum or milk which contain appropriate levels of specific antibodies, with those of the IgA class being most protective. In swine, and probably in most mono gastric animals, antibodies of the IgA class appear to occur in mammary secretions only, or primarily, as a result of an appropriate antigenic stimulation of the intestinal tract. This type of information, and the variables involved, is of special value when attempting to design an immunisation programme which will provide passive immunity against enteric infections.
Many enteric infections occur as enzootics, wherein young animals become infected during the suckling period or shortly after weaning. Pigs are usually protected from rotaviral or enteroviral infections during the first 2 to 5 weeks of age because of passive immunity, after which time an intestinal infection usually occurs. The occurrence and possible significance of boosting lactogenic immunity by natural re-infection or by vaccination are discussed and some results given.
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References
Appel, M.J.G., Cooper, B.J., Greisen, H. and Carmichael, L.E., 1978. Status report: Canine viral enteritis. J. Am. Vet. Med. Assoc. 173, 1516.
Bohl, E.H., 1975. Transmissible gastroenteritis. In: Diseases of Swine, Ed. by H.W. Dunne and A.D. Leman, p. 168. Iowa State University Press, Ames, Iowa.
Bohl, E.H., 1979. Diagnosis of diarrhea in pigs due to transmissible gastroenteritis virus or rotavirus. In: Viral Enteritis in Humans and Animals. Ed. By F. Bricout and R. Scherrer. INSERM Colloq. 90, 341.
Bohl, E.H. and Saif, L.H., 1975. Passive immunity in transmissible gastroenteritis of swine: Immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes. Infect. Immun. 11, 23.
Bohl, E.H., Gupta, R.K.P., Olquin, M.V.F. and Saif, L.J., 1972. Antibody responses in serum, colostrum and milk of swine after infection or vaccination with transmissible gastroenteritis virus. Infect. Immun. 6, 289.
Bohl, E.H., Saif, L.J., Gupta, R.K.P. and Frederick, G.T., 1974. Secretory antibodies in milk of swine against transmissible gastroenteritis virus. Adv. Exp. Med. Biol. 45, 337.
Bohl, E.H., Frederick, G.T. and Saif, L.J., 1975. Passive immunity in transmissible gastroenteritis of swine: Intramuscular injection of pregnant swine with a modified live-virus vaccine. Am. J. Vet. Res. 36, 267.
Bohl, E.H., Kohler, E.M., Saif, L.J., Cross, R.F., Agnes, A.G. and Theil, K.W., 1978. Rotavirus as a cause of diarrhea in pigs. J. Am. Vet. Med. Assoc. 172, 613.
Bourne, F.J. and Curtis, Jill, 1973. The transfer of immunoglobulins IgG, IgA and IgM from serum to colostrum and milk in the sow.Immunology 24, 157.
Brown, T.T. Jr., Paul, P.S., and Mengeling, W.L., 1980. Response of conventionally raised weanling pigs to experimental infection with a virulent strain of porcine parvovirus. Am. J. Vet. Res. 41, 1221.
Carmichael, L.C., Joubert, J.C. and Pollock, R.V.H., 1980. Hemagglutination by canine parvovirus: Serologic studies and diagnostic applications. Am. J. Vet. Res. 40, 784.
Carlson, J.H. and Scott, F.W., 1977. Feline panleukopenia. II. The relationship of intestinal mucosal cell proliferation rates to viral infection and development of lesions. Vet. Pathol. 14, 173.
Davis, E.V., Gregg, G.G. and Beckenhauer, W.H., 1970. Infectious feline panleukopenia (Developmental report of a tissue culture origin formalin inactivated vaccine). Vet. Med./Small Anim. Clin. 65, 237.
Curtis, Jill and Bourne, F.J., 1971. Immunoglobulin quantitation in sow serum, colostrum and milk and the serum of young pigs. Biochim. Biophys. Acta. 236, 319.
De Leeuw, P.W., Ellens, G.J. and Hilbink, F.W., 1979. Rotavirusassociated recurrent diarrhoea in nursing piglets. In: Viral Enteritis in Humans and Animals. Ed. by F. Bricout and R. Scherrer. INSERM Colloq. 90, 349.
Evans, P.A., Newby, T.J., Stokes, C.R., Patel, D. and Bourne, F.J., 1980. Antibody responses of the lactating sow to oral immunisation with Escherichia eoli. Scand. J. Immunol. 11, 419.
Flewett, T.H. and Woode, G.N., 1978. The rotaviruses. Brief review. Arch. Virol. 57, 1.
Goldblum, R.M., Ahlstedt, S., Carlsson, B., Hanson, L.A., Jodal, V., Lidin-Janson, G. and Sohl-Akerlund, A., 1975. Antibody-forming cells in human colostrum after oral immunisation. Nature 257, 797.
Haelterman, E.O., 1965. Lactogenic immunity to transmissible gastro- enteritis of swine. J. Am. Vet. Med. Assoc. 147, 1661.
Hess, R.G., Bachman, P.A. and Mayr, A., 1978. Attempts to develop an immunoprophylaxis against transmissible gastroenteritis (TGE) in pigs. III. Passive immune transfer after oral vaccination with attenuated TGE virus strain B1. Zentralbl Veterinaermed B 25, 308.
Kaji T. and Shimizu, Y., 1978. Passive immunisation against transmissible gastroenteritis virus in piglets by ingestion of milk of sows inoculated with attenuated virus. Natl. Inst. Anim. Health Q. ( Tokyo ) 18, 43.
Knowles, N.J., Buckley, L.S. and Pereira, H.G., 1979. Classification of porcine enteroviruses by antigenic analysis and cytopathic effects in tissue culture: Description of 3 new serotypes. Arch. Virol. 62, 201.
Kohler, E.M., 1978. Results of 1976 field trials with oral Escherichia coli vaccination of sows. Vet. Med./Small Anim. Clin. 73, 352.
Kohler, E.M., Cross, R.F. and Bohl, E.H., 1975. Protection against neonatal enteric colibacillosis in pigs suckling orally vaccinated sows. Am. J. Vet. Res. 36, 757.
Lipkin, M., 1973. Proliferation and differentiation of gastrointestinal cells. Physiol. Rev. 53, 891.
Michalek, S.M., McGhee, J.R., Mestecky, J., Arnold, R.R. and Bozzo, L., 1976. Ingestion of Streptococcus mutans induces secretory immunoglobulin A and carries immunity. Science 192, 1238.
Montgomery, P.C., Cohn, J. and Lally, E.T., 1974. The induction and characteristics of secretory IgA antibodies. Adv. Exp. Med. Biol. 45, 453.
Moon, H.W., 1971. Epithelial cell migration in the alimentary mucosa of the suckling pig. Proc. Soc. Exp. Biol. 137, 151.
Moon, H.W., 1978. Mechanisms in the pathogenesis of diarrhea:A review.J. Am. Vet. Med. Assoc. 172, 443.
Morin, M., Solorzano, R.F., Morehouse, L.G. and Olson, L.D., 1978. The postulated role of feeder swine in the perpetuation of the transmissible gastroenteritis virus. Can. J. Comp. Med. 42, 379.
Nagura, H., Nakane, D.K. and Brown, W.R., 1978. Breast milk IgA binds to jejunal epithelial in suckling rats. J. Immunol. 120, 1330.
Payne, L.C. and Marsch, C.L., 1962. Gamma globulin absorption in the baby pig: The nonselective absorption of heterologous globulins and factors influencing absorption time. J. Nutr. 76, 151.
Pensaert, M.B., 1979. Immunity in TGE of swine after infection and vaccination. In: Viral Enteritis in Humans and Animals. Ed. by F. Bricout and R. Scherrer. INSERM Colloq. 90, 281.
Porter P. and Allen, W.D., 1972. Classes of immunoglobulins related to immunity in the pig. J. Amer. Vet. Med. Assoc. 160, 511.
Roux, M.E., McWilliams, M., Phillips-Quagliata, J.M., Weisz-Carrington, P. and Lamm, M.E., 1977. Origin of IgA-secretory plasma cells in the mammary gland. J. Exp. Med. 146, 1311.
Saif, L.J. and Bohl, E.H., 1977. Immunoglobulin classes of antibodies in milk of swine after intranasal exposure to pseudorabies virus or transmissible gastroenteritis virus. Infect. Immun. 16, 961.
Saif, L.J. and Bohl, E.H., 1979. Role of secretory IgA in passive immunity of swine to enteric viral infections. In: Immunology of Breast Milk. Ed. by P.L. Ogra and D. Dayton, p. 237. Raven Press, New York.
Saif, L.J., Bohl, E.H. and Gupta, R.K.P., 1972. Isolation of porcine immunoglobulins and determinations of the immunoglobulin classes of transmissible gastroenteritis viral antibodies. Infect. Immun. 6, 289.
Singh, K.V. and Bohl, E.H., 1972. The pattern of enteroviral infections in a herd of swine. Can. J. Comp. Med. 36, 243.
Stepanek, J., Mensik, J., Franz, J. and Hornich, M., 1979. Epizootiology, diagnosis and prevention of viral diarrhoea in piglets under intensive husbandry conditions. Proc. 21st World Vet. Congr. ( Moscow ) 6, 43.
Svennerholm, A.M., Holmgren, J., Hanson, L.A., Lindblad, B.S., Qureshi, F. and Rahimtoola, R.J., 1977. Boosting of secretory IgA antibody responses in man by parenteral cholera vaccination. Scand. J. Immunol. 6, 1345.
Tajima, M., 1970. Morphology of transmissible gastroenteritis virus of pigs. A possible member of coronaviruses. Arch. ges Virus Forsch. 29, 105.
Tamoglia, T.W., 1972. Present status of products available for use against transmissible gastroenteritis. J. Am. Vet. Med. Assoc. 160 554.
Wenner, H.A., Beran, G.W. and Werder, A.A., 1960. Enteroviruses of swine.II. Studies on the natural history of infection and immunity. Am. J. Vet. Res. 21, 958.
Woode, G.N., Bridger, J.C., Hall, G.A., Jones, J.M. and Jackson, G., 1976. The isolation of reovirus-like agents (rotaviruses) from acute gastroenteritis of piglets. J. Med. Microbiol. 9, 203.
Woods, R.D., 1978. Small plaque variant transmissible gastroenteritis virus. J. Am. Vet. Med. Assoc. 173, 643.
Woods, R.D. and Pedersen, N.C., 1979. Cross-protection studies between feline infectious peritonitis and porcine transmissible gastroenteritis viruses. Vet. Microbiol. 4, 11.
Woods, R.D., Cheville, N.F. and Gallagher J.E., 1980. Lesions in the small intestine of newborn pigs inoculated with porcine, feline, and canine coronaviruses. Am. J. Vet. Res. (in press).
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© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
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Bohl, E.H., Saif, L.J. (1981). Passive Immunity Against Enteric Viral Infections of Piglets. In: Bourne, F.J. (eds) The Mucosal Immune System. Current Topics in Veterinary Medicine and Animal Science, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8331-1_12
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