Advertisement

The Radiopharmacological Behaviour of Ida-Derivatives in Normal Experimental Animals

  • P. H. Cox
Part of the Developments in Nuclear Medicine book series (DNUM, volume 1)

Abstract

Whilst Technetium-Ida derivatives all show basically similar patterns of biodistribution and as such are suited for cholescintigraphy they nevertheless differ significantly enough from each other to have warranted more detailed comparisons to select the reagent most suited for cholescintigraphy in humans.

Keywords

Blood Clearance Rose Bengal Iminodiacetic Acid Diacetic Acid Minute Post Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Loberg MD et al, Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. J. nucl. Med. 17: 633, 1976.PubMedGoogle Scholar
  2. 2.
    Ryan J et al, Technetium-99m-labelled N (216-dimethylcarbamoyl methyl) iminodiacetic acid: A new radiopharmaceutical for hepatobiliary imaging studies. J. nucl. Med. 17: 545, 1977.Google Scholar
  3. 3.
    Chiotellis E et al, 99mTc-Hida a gall-bladder imaging agent. Experimental aspects. Eur. J. nucl. Med. 3:41, 1978.Google Scholar
  4. 4.
    Wistow BW et al, An evaluation of 99mTc-hepatobiliary imaging agents. J. nucl. Med. 18: 455, 1977.PubMedGoogle Scholar
  5. 5.
    Smith RB et al, Pharmacokinetics of hepatobiliary imaging agents in rats. J. nucl. Med. 20: 45, 1979.PubMedGoogle Scholar
  6. 6.
    Subramanian G et al, The influence of structural changes on biodistribution of 99mTc N-substituted Ida derivatives. In: Nuklearmedizin. Proceedings 15th International Congress Society of Nuclear Medicine (Europe). Schmidt HAE, Woldring MG (eds), Groningen, 1977.Google Scholar
  7. 7.
    Zivanovic M et al, The stability and distribution of Tc-Hida in vivo and in vitro. Eur. J. nucl. Med. 4: 369, 1979.PubMedGoogle Scholar
  8. 8.
    Cox PH, The comparative pharmacology of technetium ida derivatives. In: Progress in Radiopharmacology. Vol.l. Cox PH (ed), Amsterdam, Elsevier/ North-Holland Biomedical Press, 1979.Google Scholar
  9. 9.
    Burns D et al, Relationship between molecular structure and biliary excretion of Tc99m Hida and Hida analogues. J. nucl. Med. 18: 624, 1977.Google Scholar
  10. 10.
    Chiotellis E, Varvarigou A, 99mTc labelled N-substituted carbamoyl iminodiacetates: Relationship between structure and distribution. Int. J. nucl. Med. Biol. 7: 1, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Tjen HSLM, Cholescintigraphy. Ph.D. Thesis, University of Utrecht, The Netherlands (in English ), 1979.Google Scholar
  12. 12.
    Harvey E et al, Hepatic clearance mechanism of Tc99m Hida and its effect on quantitation of hepato biliary function: consise communication. J. nucl. Med. 20: 310, 1979.PubMedGoogle Scholar
  13. 13.
    Kitani K et al, Inhibiting effect of sulphobromophthalein (BSP) on the hepatic uptake and biliary excretion of 99mTc Hida in rats. Jap. J. nucl. Med. 15: 999, 1978.Google Scholar
  14. 14.
    Kitani K et al, Inhibiting effect of sulphobromophthalein on the hepatic uptake and biliary excretion of 99mTc-N (2.6 dimethylphenylcarbamoylmethyl) diacetic acid and pyridoxylene isoluceine in rats. J. nucl. Med. 20: 642, 1979.Google Scholar
  15. 15.
    Porter DW et al, Comparison of hepatobiliary radiopharmaceuticals in an in vitro model. J. nucl. Med. 20: 642, 1979.Google Scholar
  16. 16.
    Fritzberg AR et al, Hepatobiliary mechanism of Tc99m-N (2.6 diethylacetanilido)iminodiacarboxylic acid (Diethylida). J. nucl. Med. 20: 642, 1979.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, The Hague 1981

Authors and Affiliations

  • P. H. Cox

There are no affiliations available

Personalised recommendations