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Amino Acid and Protein Metabolism in Chronic Renal Failure

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Book cover Pediatric Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 3))

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Summary

Protein malnutrition is common in uraemia. Protein synthesis is probably reduced but protein breakdown is not increased at least under basal conditions. The reduction in protein synthesis may be due to a direct effect of an unidentified uraemic toxin(s) but, in addition, the adaptation to altered energy metabolism may reduce protein synthesis by increasing branch chain amino acid oxidation with a consequent reduction in the extracellular and intracellular pools of branch chain amino and keto acids. Lowering nitrogen toxicity by reducing nitrogen intake and supplementing with essential amino acids or keto acids may improve growth in some children.

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Author information

Authors and Affiliations

  1. Evelina Department of Paediatrics, Guy’s Hospital, London, SE1 9RT, UK

    C. Chantler, R. W. A. Jones & N. Dalton

Authors
  1. C. Chantler
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  2. R. W. A. Jones
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  3. N. Dalton
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Editor information

Editors and Affiliations

  1. St. Christopher’s Hospital for Children, Philadelphia, PA, USA

    Alan B. Gruskin MD (President) (President)

  2. Section of Nephrology, Children’s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA, 19104, USA

    Michael E. Norman MD (Secretary General) (Secretary General)

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© 1981 Martinus Nijhoff Publishers, The Hague

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Chantler, C., Jones, R.W.A., Dalton, N. (1981). Amino Acid and Protein Metabolism in Chronic Renal Failure. In: Gruskin, A.B., Norman, M.E. (eds) Pediatric Nephrology. Developments in Nephrology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8319-9_39

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  • DOI: https://doi.org/10.1007/978-94-009-8319-9_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8321-2

  • Online ISBN: 978-94-009-8319-9

  • eBook Packages: Springer Book Archive

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