Penetration of Various Antibiotics into Sputum
Various antibiotics that can be administered orally have been investigated in respect of sputum levels by several authors. Table 1 shows that peak sputum concentrations were five times higher after a single dose of 0.2 g minocycline than after the recommended single dose of 0.1 g doxycycline. During continuous treatment with other drugs in the usual dosages, peak sputum levels were highest with erythromycin, followed by amoxycillin, cefaclor, cefalexin and ampicillin. In relation to the in vitro sensitivity of Haemophilus influenzae to several antibiotics (Table 2), these findings suggest that the antibiotic concentrations reached are not sufficient to eliminate such bacteria from the sputum in all cases, but we know that host defense mechanisms may enhance the antibacterial efficacy of a drug.
KeywordsHaemophilus Influenzae Antibiotic Concentration Healthy Adult Volunteer Bronchial Secretion Oral Cephalosporin
- 1.Simon C, Sommerwerck D, Friehoff J: Der Wert von Doxycyclin bei Atemwegsinfektionen (Serum-, Speichel-, Sputum-, Lungen-und Pleuraexsudatspiegel). Praxis und Klinik der Pneumologie 32: 217, 1978Google Scholar
- 3.Simon C, Clasen I: Sputum concentrations of erythromycin after single and repeated oral administration in adult patients with bronchitis. Current Chemother 652, 1978.Google Scholar
- 4.Simon C, Gatzemeier U: Serum and sputum levels of cefaclor. Med J 55: 30, 1979.Google Scholar
- 5.Halprin GM, McMahon SM: Cephalexin concentrations in sputum during acute respiratory infections. Antimicrobial Agents Chemother 3: 703, 1973.Google Scholar
- 6.May JR: Chemotherapy of Chronic Bronchitis and Allied Disorders. Engl. Universities Press, London, 1968, p. 33.Google Scholar