Abstract
Even those who are only slightly familiar with pharmacokinetic concepts will know that the two-compartment open model is often used in explaining the course of plasma concentrations of a drug [1]. What is often forgotten is that this model is primarily not a biological model but a mathematical one, although the latter is compatible with some biological facts. This has led to the assumption that a biological model is the basis for the mathematical model.
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© 1981 Martinus Nijhoff Publishers, The Hague
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Mattie, H. (1981). General Review on Pharmacokinetics of Antimicrobial Drugs in Relation to Respiratory Infections. In: Van Furth, R. (eds) Developments in Antibiotic Treatment of Respiratory Infections. New Perspectives in Clinical Microbiology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8305-2_6
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DOI: https://doi.org/10.1007/978-94-009-8305-2_6
Publisher Name: Springer, Dordrecht
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