Epidemiological Evidence for a Hereditary Component in Crohn’s Disease
Evidence for a significant familial incidence of Crohn’s disease has been presented from many sources (1–5). Despite this, geneticists have not yet concluded that this familial association has a hereditary basis. The traditional lines of investigation of the past into the etiology of Crohn’s disease such as dietary and psychosomatic have lost their enthusiasts, immunological factors seem to have a supplementary role and even the recently promising microbiological transmission studies warrant less hope than earlier (6). It is therefore understandable for the gastroenterologist to turn once again to his patients to find whether the strong familial association observed clinically is statistically significant and whether any new direction for further investigation might be forthcoming through this route.
KeywordsInflammatory Bowel Disease Ulcerative Colitis Familial Association Hereditary Component Flammatory Bowel Disease
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