Epidemiological Evidence for a Hereditary Component in Crohn’s Disease

  • B. I. Korelitz
Part of the Developments in Gastroenterology book series (DIGA, volume 1)


Evidence for a significant familial incidence of Crohn’s disease has been presented from many sources (1–5). Despite this, geneticists have not yet concluded that this familial association has a hereditary basis. The traditional lines of investigation of the past into the etiology of Crohn’s disease such as dietary and psychosomatic have lost their enthusiasts, immunological factors seem to have a supplementary role and even the recently promising microbiological transmission studies warrant less hope than earlier (6). It is therefore understandable for the gastroenterologist to turn once again to his patients to find whether the strong familial association observed clinically is statistically significant and whether any new direction for further investigation might be forthcoming through this route.


Inflammatory Bowel Disease Ulcerative Colitis Familial Association Hereditary Component Flammatory Bowel Disease 
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  1. 1.
    Kirsner JB, Spencer JA. (1973) Familial occurrences of ulcerative colitis, regional enteritis and ileocolitis. Ann.Int.Med. 59:133–144Google Scholar
  2. 2.
    Almy TP, Sherlock P. (1966) Genetic aspects of ulcerative colitis and regional enteritis. Gastroenterology 51:757–763PubMedGoogle Scholar
  3. 3.
    Singer HC, Anderson JGD, Frischer H, Kirsner JB. (1971) Familial aspects of inflammatory bowel disease. Gastroenterology 61:423–430PubMedGoogle Scholar
  4. 4.
    Kirsner JB. (1973) Genetic aspects of inflammatory bowel disease. In: Clinics in Gastroenterology. Ed. McConnell RB, WB Saunders, Philadelphia Vol 2: pp 557–575Google Scholar
  5. 5.
    Farmer RG, Michener WM, Mortimer EA. (1980) Studies of family history among patients with inflammatory bowel disease. In: Clinics in Gastroenterology. Ed. Farmer RG, WB Saunders, Philadelphia Vol 9: pp 271–278Google Scholar
  6. 6.
    Gitnick GL. (1979) Etiology of inflammatory bowel disease. Are we making progress? Gastroenterology 78:1090–1102Google Scholar
  7. 7.
    Korelitz BI. (1979) From Crohn to Crohn’s disease:1979. An epidemiological study in New York City. Mt.Sinai J.Med. 46:533–540Google Scholar
  8. 8.
    Falconer DS. (1965) The inheritance of liability to certain diseases estimated from the incidence among relatives. Ann.Hum.Genet. 29:51–76CrossRefGoogle Scholar
  9. 9.
    Lewkonia RM, McConnell RB. (1976) Familial IBD-heredity or environment? Gut 17:235–243PubMedCrossRefGoogle Scholar
  10. 10.
    McConnell RB. (1966) Crohn’s disease and Ulcerative Colitis. In: The Genetics of Gastrointestinal Disorders. Ed. McConnell RB, Oxford Univ. Press, London, pp 128–142Google Scholar
  11. 11.
    Emery AEH, Lawrence JS. (1974) Genetics of ankylosing spondylitis. J.Med.Genet. 4:239–244CrossRefGoogle Scholar
  12. 12.
    Kemler BJ, Glass D, Alpert E. (1980) HLA studies of families with multiple cases of inflammatory bowel disease [IBD]. Gastroenterology 78:1194Google Scholar

Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1981

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  • B. I. Korelitz

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