Abstract
Recent work on the pathogenesis of Crohn’s disease has focused attention largely on immunological mechanisms (1,2) and on the possible role of a transmissible agent (3). It has been suggested that a virus is the most likely source of antigen[s] initiating the immunological reaction (4). If one assumes that these transmissible agents are ubiquitous, why then should Crohn’s disease develop in only a minority of the population? Genetic characteristics might influence individual susceptibility to Crohn’s disease. The involvement of genetic factors is suggested by a familial tendency (5) as well as by immunological abnormalities found in both Crohn’s disease patients and their families (6).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Strickland RG, Miller WC, Volpicelli NA, Gaeke RF, Wilson ID, Kirsner JB, Williams RC.Jr. (1977) Lymphocytotoxic antibodies in patients with inflammatory bowel disease and their spouses — evidence for a transmissible agent. Clin.Exp.Immunol. 30:188–192
Kagnoff MF. (1978) On the etiology of Crohn’s disease. Gastroenterology 75:526–527
Cave DR, Mitchell DN, Brooke BN. (1975) Observations on the transmissibility of Crohn’s disease and ulcerative colitis. Gastroenterology 68:871
Gitnick GL, Rosen VJ, Arthur MH, Hertweck SA. (1979) Evidence for the isolation of a new virus from ulcerative colitis patients. Comparison with virus derived from Crohn’s disease. Dig.Dis.Sci. 24:609–619
Lewkonia RM, McConnell RB. (1976) Familial IBD — heredity or environment? Gut 17:235–243
Watson DW, Shorter RG. (1975) The immunology of ulcerative colitis and Crohn’s disease: Cell mediated immune responses. In: Inflammatory Bowel Disease. Eds. Kirsner JB, Shorter RG. Lea and Febiger, Philadelphia, pp 81–98
Asquith P, Mackintosh P, Stokes PL, Holmes GKT, Cooke WT. (1974) Histocompatibility antigens in patients with inflammatory bowel disease. Lancet 1:113–115
Berg van den-Loonen EM, Dekker-Saeys BJ, Meuwissen SGM, Nijenhuis LE, Engelfriet CP. (1976) Histocompatibility antigens and other genetic markers in ankylosing spondylitis and IBD. J.Immunogenet. 4:167–175
Delpre G, Kadish U, Gazit E, Joshua H, Zamit R. (1980) HLA antigens in ulcerative colitis and Crohn’s disease in Israel. Gastroenterology 78:1452–1457
Compston DA, Batchelor JR, McDonald WI. (1976) B-Lymphocyte alloantigens associated with multiple sclerosis. Lancet 2:1261–1265
Mann DL, Katz SI, Nelson DL, Abelson LB, Strober W. (1976) Specific B-cell antigens associated with gluten sensitive enteropathy and dermatitis herpetiformis. Lancet 1:110–111
Rood van JJ, Leeuwen van A, Ploem JS. (1976) Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Nature 262:795–797
Thorsby E, Lie SO. (1971) Relationship between the HL-A system and susceptibility to diseases. Trans.Proc. 3:1305–1307
Jacoby RK, Jayson MI. (1974) HL-A 27 in Crohn’s disease. Ann.Rheum.Dis. 33:422–424
Gleeson MH, Walker JS, Wentzel J, Chapman JA, Harris R. (1972) Human leucocyte antigens in Crohn’s disease and ulcerative colitis. Gut 13:438–440
In: The role of products of the histocompatibility gene complex in the immune response. Eds. Katz DA, Benacerraf B. Acad.Press, New York(1980)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Martinus Nijhoff Publishers bv, The Hague
About this chapter
Cite this chapter
Cohen, Z., McCulloch, P., Leung, M.K., Mervart, H. (1981). Histocompatibility Antigens in Patients with Crohn’s Disease. In: Peña, A.S., Weterman, I.T., Booth, C.C., Strober, W. (eds) Recent Advances in Crohn’s Disease. Developments in Gastroenterology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8273-4_41
Download citation
DOI: https://doi.org/10.1007/978-94-009-8273-4_41
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8275-8
Online ISBN: 978-94-009-8273-4
eBook Packages: Springer Book Archive