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An Index of Inflammatory Activity in Patients with Crohn’s Disease

  • P. A. M. Van Hees
  • Ph. Van Elteren
  • H. J. J. Van Lier
  • J. H. M. Van Tongeren
Part of the Developments in Gastroenterology book series (DIGA, volume 1)

Abstract

Crohn’s disease [CD] is a condition which encompasses a wide variety of complaints and symptoms. These may be related to the inflammatory activity, but even when there is little activity there may be considerable subjective complaints — for example, of abdominal pain as a result of the presence of an inactive fibrous stricture. This diversity of the causes of the complaints and the lesions found greatly impedes exact evaluation of the effect of various types of therapeutic medication on the inflammatory activity. During the preparations for a prospective study which was to establish the effects of various types of therapeutic medication on the inflammatory activity in CD, the need arose for an optimally objective and quantifiable standard of inflammatory activity. The Crohn’s Disease Activity Index [CDAI] described by Best et al. (1) has, we believe, several disadvantages. With the aid of data from a retrospective study, we therefore attempted to develop a more suitable activity index — that is, an optimally objective and reproducible quantitative standard of inflammatory activity — for patients with CD.

Keywords

Inflammatory Activity Serum Albumin Level Stool Consistency Relate Body Weight Therapeutic Medication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Best WR, Becktel JM, Singleton JW, Kern F.Jr. (1976) Development of a Crohn’s disease activity index (National Cooperative Crohn’s Disease Study). Gastroenterology 70:439–444PubMedGoogle Scholar
  2. 2.
    Hees PAM, Elteren van PH, Lier van HJJ, Tongeren van JHM. (1980) An index of inflammatory activity in patients with Crohn’s disease. Gut 21:279–286PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1981

Authors and Affiliations

  • P. A. M. Van Hees
  • Ph. Van Elteren
  • H. J. J. Van Lier
  • J. H. M. Van Tongeren

There are no affiliations available

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