Abstract
Although the pathology of Crohn’s disease [CD] is characterized by well-defined regions of gross inflammation, it has long been recognised that it is a widely disseminated disease of the gut. Brooke first described “aphthoid ulcers” in the mucosa of otherwise uninflamed intestine of CD in 1953 (1). Morson (2) found that these lesions consisted of lymphoid follicles that were involved in the granulomatous inflammation of CD with break-down and pin-point mucosal ulceration. Recently Dvorak (3) and Rickert et al. (4) have correlated these ulcers with their surface appearance by scanning electron microscopy, in addition pointing out the considerable enhancement of mucous secretion and the villous fusion in “unaffected” areas that can be observed using this technique.
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References
Brooke BN. (1953) What is ulcerative colitis? Lancet 1:1220–1225
Morson BC. (1972) The early histological lesion of Crohn’s disease. Proc.Roy.Soc.Med. 65:71–72
Dvorak HM, Dickersin GR, Osage JC, Monahan RA. (1978) Absence of virus structures in Crohn’s disease tissues studied by electron microscopy. Lancet 1:328-
Rickert RR, Carter HW. (1977) The gross light microscopic and scanning electron microscopy appearance of the early lesions of Crohn’s disease. Scanning Electron Microscopy 11:179–186
Tytgat GN, Minnen van A, Verhoeven A. (1979) Electronen microscopisch onderzoek van granulomen bij de ziekte van Crohn. Tijdschr.Gastroenterol. 21:465–480
Yarom R, Maunder C, Scripps M, Hall TA, Dubowitz VA. (1975) A simplified preparation for X-ray microanalysis of muscle and blood cells. Histochemistry 45:49–59
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© 1981 Martinus Nijhoff Publishers bv, The Hague
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Dourmashkin, R.R. et al. (1981). Early Epithelial Lesions in Crohn’s Disease, Revealed by Electron Microscopy. In: Peña, A.S., Weterman, I.T., Booth, C.C., Strober, W. (eds) Recent Advances in Crohn’s Disease. Developments in Gastroenterology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8273-4_27
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DOI: https://doi.org/10.1007/978-94-009-8273-4_27
Publisher Name: Springer, Dordrecht
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