Electronmicroscopy in Crohn’s Disease

  • G. N. Tijtgat
  • A. Van Minnen
  • T. Verhoeven
Part of the Developments in Gastroenterology book series (DIGA, volume 1)


Surprisingly few EM studies have been performed on tissue obtained from patients with Crohn’s disease (1–9). The purpose of this EM study was to find out whether EM could provide any clues to the etiology or pathogenesis of CD.


Giant Cell Epithelioid Cell Identifiable Structure Epithelioid Cell Granuloma Focal Edema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Albot G, Parturier-Albot M, Camilleri JP, Diebold J. (1970) La maladie de Crohn colique. IV. Etude cytologique et ultrastructurale des infiltrants inflammatoires plasmocytaires et epithelio-giganto-cellulaires. Sem. Hôp. Paris 46:1545–1566PubMedGoogle Scholar
  2. 2.
    Aluwihare APR.(1971) Electron microscopy in Crohn’s disease. Gut 12:509–518Google Scholar
  3. 3.
    Aluwihare APR.(1971) The ultrastructure of the colon in Crohn’s disease. Proc. Roy. Soc. Med. 64:162–164PubMedGoogle Scholar
  4. 4.
    Aluwihare APR. (1976) Clin. Gastroenterol. 5:279Google Scholar
  5. 5.
    Cook MG, Turnbull GJ. (1975) A hypothesis for the pathogenesis of Crohn’s disease based on an ultrastructural study. Virchows Arch. A [Pathol.Anat.] 365:327–336CrossRefGoogle Scholar
  6. 6.
    Dourmashkin RR, Davies H, Wells C. Shah D, Price A, O’Morain C, Levi J, Hall Th.A. (1980) These proceedingsGoogle Scholar
  7. 7.
    Gebbers JO, Otto HF. (1980) Immuno-and ultracytochemical observations in Crohn’s disease. These proceedingsGoogle Scholar
  8. 8.
    Ranlov P, Nielsen MH, Wanstrup J. (1972) Ultrastructure of ileum in Crohn’s disease. Scand.J.Gastroenterol. 7:471–476PubMedCrossRefGoogle Scholar
  9. 9.
    Riemann JF. (1977) Further electronmicroscopic evidence of Virus-like particles in Crohn’s disease. Acta Hepato-Gastroenterol. 24:116–118Google Scholar
  10. 10.
    Epstein WL.(1967) Granulomatous hypersensitivity. Progr. Allerg. 11:36–88PubMedGoogle Scholar
  11. 11.
    Spector WG.(1976) Immunologic components of granuloma formation. Epithelioid cells, giant cells, and sarcoidosis. Ann. N.Y. Acad. Sci. 278:3–6PubMedCrossRefGoogle Scholar
  12. 12.
    Cardella CJ, Davies P, Alloson AC. (1974) Immune complexes induce selective release of lysosomal hydrolases from macrophages. Nature 247:46–48PubMedCrossRefGoogle Scholar
  13. 13.
    Dingle JT, Poole AR, Lazarus GS, Barrett AJ. (1973) Immunoinhibition of intracellular protein digestion in macrophages. J. Exp. Med. 137:1124–1141PubMedCrossRefGoogle Scholar
  14. 14.
    Tytgat GN, van Minnen A, Verhoeven A. (1979) Electronen microscopisch onderzoek van granuloma bij de ziekte van Crohn. Tijdschr. Gastroenterol. 21:465–480Google Scholar
  15. 15.
    Cohn ZA, Benson B. (1965) The diffentiation of mononuclear phagocytes. J.Exp.Med. 121:153–169PubMedCrossRefGoogle Scholar
  16. 16.
    Klockars M, Reitamo S, Reitamo JJ, Moller C. (1977) Immunohistochemical identification of lysozyme in intestinal lesions in ulcerative colitis and Crohn’s disease. Gut 18:377–381PubMedCrossRefGoogle Scholar
  17. 17.
    Sutton JS, Weiss L. (1966) Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells. An electronmicroscopic study. J.Cell Biol. 28:303–332PubMedCrossRefGoogle Scholar
  18. 18.
    Williams D, Williams JW, Williams JE. (1969) Enzyme histochemistry of epithelioid cells in sarcoid-like granulomas. J.Path. 97:705–709PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1981

Authors and Affiliations

  • G. N. Tijtgat
  • A. Van Minnen
  • T. Verhoeven

There are no affiliations available

Personalised recommendations