Immunoglobulin-Containing Cells in Colonic and Rectal Mucosa in Crohn’s Disease
The large number of plasma cells and lymphocytes in the lamina propria of the large bowel mucosa in patients with Crohn’s disease suggests that an immunological mechanism plays a role in the pathogenesis of this disease. Earlier studies on immunoglobulin-containing cells in Crohn’s disease were performed with immunofluorescence techniques (1,2,3). Skinner and Whitehead (2) and Baklien and Brandtzaeg (3) showed that in Crohn’s disease of the colon the increase was greatest for IgG and IgM. O’Donoghue and Kumar (4) found in ulcerative colitis and Crohn’s disease a marked increase in IgE-containing cells in rectal mucosa.
KeywordsUlcerative Colitis Rectal Mucosa Inflame Mucosa Flammatory Bowel Disease Meijer CJLM
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