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Immunoglobulin-Containing Cells in Colonic and Rectal Mucosa in Crohn’s Disease

  • P. C. M. Rosekrans
  • C. J. L. M. Meijer
  • J. Lindeman
Part of the Developments in Gastroenterology book series (DIGA, volume 1)

Abstract

The large number of plasma cells and lymphocytes in the lamina propria of the large bowel mucosa in patients with Crohn’s disease suggests that an immunological mechanism plays a role in the pathogenesis of this disease. Earlier studies on immunoglobulin-containing cells in Crohn’s disease were performed with immunofluorescence techniques (1,2,3). Skinner and Whitehead (2) and Baklien and Brandtzaeg (3) showed that in Crohn’s disease of the colon the increase was greatest for IgG and IgM. O’Donoghue and Kumar (4) found in ulcerative colitis and Crohn’s disease a marked increase in IgE-containing cells in rectal mucosa.

Keywords

Ulcerative Colitis Rectal Mucosa Inflame Mucosa Flammatory Bowel Disease Meijer CJLM 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Crabbe PA, Heremans JF. (1966) The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology 51:305–316PubMedGoogle Scholar
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    Skinner JM, Whitehead R. (1974) The plasma cells in inflammatory bowel disease of the colon. A quantitative study. J.Clin.Pathol. 27:643–646PubMedCrossRefGoogle Scholar
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    Baklien K, Brandtzaeg P. (1975) Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative colitis and Crohn’s disease of the colon. Clin.Exp.Immunol. 22:197–209PubMedGoogle Scholar
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    Morson BC. (1974) In:Pathology Annual.Ed. Sommers SC. Appleton-Century Crofts New York pp. 209–230Google Scholar
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    Meijer CJLM, Rosekrans PCM, Lindeman J. (1980) B-cell system and Crohn’s disease. These proceedingsGoogle Scholar
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    Rosekrans PCM, Meijer CJLM, Wal van der AM, Cornelisse CJ, Lindeman J. (1980) Immunoglobulin-containing cells in inflammatory bowel disease of the colon (A morphometric and immunohistochemical study) Gut, in pressGoogle Scholar
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    Brandtzaeg P, Baklien K, Fausa O, Hoel PS. (1974) Immunohistochemical characterization of local immunoglobulin formation in ulcerative colitis. Gastroenterology 66:1123–1136PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers bv, The Hague 1981

Authors and Affiliations

  • P. C. M. Rosekrans
  • C. J. L. M. Meijer
  • J. Lindeman

There are no affiliations available

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