The Histopathological Evolution of Crohn’s Disease
Crohn’s disease may be caused by several different agents, only some of which cause granuloma formation.
Granulomas may appear in Crohn’s disease in some patients following mucosal ulceration and consequent access to the diseased bowel wall by granuloma-inducing luminal agents. This theoretical possibility is rendered less likely by the observation that other diseases in which mucosal ulceration occurs are not associated with the presence of granulomas.
A single aetiological agent of Crohn’s disease may only cause granuloma formation in some patients [cf tuberculoid and lepromatous leprosy].
Granulomas may be present only in certain phases of the disease [cf sarcoid, lymphogranuloma venereum].
KeywordsCoeliac Disease Granuloma Formation Mucosal Ulceration Aetiological Agent Lepromatous Leprosy
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