Abstract
The crucial considerations in selecting a research design to test drug efficacy include:
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1.
Validity: If the drug is not effective, is the chance of a false positive finding less than 5% or 1%?
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2.
Power Efficiency: If the drug is effective, is the chance of a true positive finding reasonably high?
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3.
Feasibility and Cost: Can the design be reasonably implemented in the research situation for which it is proposed?
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4.
Clinical Value: Does the design yield information sufficient in extent and quality to serve as a basis for evaluation of the clinical value of the drug?
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References
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© 1981 Martinus Nijhojf Publishers bv, The Hague.
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Kraemer, H.C. (1981). Parallel or Crossover Designs in Evaluation of Antiarrhythmic Therapy. In: Morganroth, J., Moore, E.N., Dreifus, L.S., Michelson, E.L. (eds) The Evaluation of New Antiarrhythmic Drugs. Developments in Cardiovascular Medicine, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8270-3_13
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DOI: https://doi.org/10.1007/978-94-009-8270-3_13
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