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Cell Kinetics of Gastrointestinal Cancer and its Precursor States

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Gastrointestinal Cancer 1

Part of the book series: Cancer Treatment and Research ((CTAR,volume 3))

Abstract

Normally there exists in the gastrointestinal mucosa an equilibrium between cell renewal and cell loss through intraluminal exfoliation and cell death. In precancerous and cancerous states, this fine balance or steady state is disturbed. This condition may sometimes be recognized by an elevation in the number of cells involved in DNA synthesis, a faster cell turnover time, or an abnormal location of the proliferative compartment. An alteration in some aspect of normal cell kinetics may reveal the presence of an abnormality even before any microscopic pathology is visible. Certain aspects of cell proliferation can in some instances then be employed as an early marker for the involvement of the mucosa in a disease state such as tumor formation.

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Authors
  1. Eleanor E. Deschner
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  2. Remy J. Salmon
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Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, USA

    Jerome J. Decosse  & Paul Sherlock  & 

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© 1981 Martinus Nijhoff Publishers, The Hague/Boston/London

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Deschner, E.E., Salmon, R.J. (1981). Cell Kinetics of Gastrointestinal Cancer and its Precursor States. In: Decosse, J.J., Sherlock, P. (eds) Gastrointestinal Cancer 1. Cancer Treatment and Research, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8255-0_1

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  • DOI: https://doi.org/10.1007/978-94-009-8255-0_1

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