Abstract
Stroke-prone spontaneously hypertensive rats (SHRSP), which were established by selective breeding (Yamori et al., 1974a; Okamoto et al., 1974), develop severe hypertension and cerebrovascular lesions in more than 90% of the population (Yamori et al., 1976). These SHRSP, as well as spontaneously hypertensive rats (SHR), are regarded as the best models to date for studies on the pathogenesis and prevention of the spontaneously developing hypertensive diseases observed in man (Yamori and Okamoto, 1974; Folkow et al., 1973).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chesney, R. W.; Jax, D. K.; Scriver, C. R.; and Mohyuddin, F. Taurine transport in mammalian kidney. In Taurine and Neurological Disorders, A. Barbeau and R. J. Huxtable. eds. Raven Press, New York (1978), pp. 73–93.
Cutler, R. W. P.; and Coull, B. M. Amino acid transport in the brain. In Taurine and Neurological Disorders, A. Barbeau and R. J. Huxtable. eds. Raven Press, New York (1978), pp. 95–107.
Davison, A. N.; and Kaczmarek, L. K. Taurine—A possible neurotransmitter? Nature, 234, 107–108 (1971).
Folkow, B.; Hallbäck, M.; Lundgren, Y.; Sivertsson, R.; and Weiss, L. Importance of adaptive changes in vascular design for establishment of primary hypertension, studied in man and in spontaneously hypertensive rats. Circulat. Res., 32 and 33 (Suppl. 1), 2–16 (1973).
Glowinski, J.; and Iversen, L. Regional studies of catecholamines in the rat brain: I. The disposition of [3H]-norepinephrine, [3H]-dopamine and [3H]-dopa in various regions of the brain. J. Neurochem., 13, 655–669 (1966).
Huxtable, R.; and Bressler, R. Taurine concentrations in congestive heart failure. Science, 184, 1187–1188 (1974).
Jacobsen, J. G.; and Smith, L. H., Jr. Biochemistry and physiology of taurine and taurine derivatives. Physiol. Rev., 48, 424–511 (1968).
Kaczmarek, L. K.; and Davison, A. N. Uptake and release of taurine from rat brain slices. J. Neurochem., 19, 2355–2362 (1972).
Lombardini, J. B. Regional and subcellular studies on taurine in the rat central nervous system. In Taurine, R. Huxtable and A. Barbeau, eds. Raven Press, New York (1976), pp. 311–326.
Nagaoka, A.; and Lovenberg, W. Regional changes in the activities of aminergic biosynthetic enzymes in the brains of hypertensive rats. Eur. J. Pharmac, 43, 297–306 (1977).
Nara, Y.; Yamori, Y.; and Lovenberg, W. Effect of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem. Pharmacol., 27, 2689–2692 (1978).
Oja, S. S.; and Lähdesmäki, P. Is taurine an inhibitory neurotransmitter? Med. Biol., 52, 138–143 (1974).
Okamoto, K.; Yamori, Y.; and Nagaoka, A. Establishment of the stroke-prone spontaneously hypertensive rats (SHR). Circulat. Res., 34 and 35 (Suppl. 1), 143–153 (1974).
Oldendorf, W. H. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol., 221, 1629–1639 (1971).
Spaeth, D. G.; and Schneider, D. L. Turnover of taurine in rat tissues. J. Nutr., 104, 179–186 (1974).
Tsunoo, Sh.; Horisaka, K.; and Yamaquchi, A. Ω-amino sulfonic acid, especially on the pharmacology and clinical application of taurine. J. Schowa, Medical Assoc, 28, 301–316 (1968) (in Japanese).
Yamori, Y. Neural and non-neural mechanisms in spontaneous hypertension. Clin. Sci. Mol. Med., 51, 431s–434s (1976).
Yamori, Y.; and Okamoto, K. Spontaneous hypertension in the rats; a model of human “essential” hypertension. Proc. 80th Congr. Germ. Soc. Intern. Med., 168–170 (1974).
Yamori, Y.; Nagaoka, A.; and Okamoto, K. Importance of genetic factors in hypertensive cerebrovascular lesions; an evidence obtained by successive selective breeding of stroke-prone and -resistant SHR. Japan. Circulat. J., 38, 1095–1100 (1974a).
Yamori, Y.; Tomimoto, K.; Ooshima, A.; Hazama, F.; and Okamoto, K. Developmental course of hypertension in the SHR—Substrains susceptible to hypertensive cerebrovascular lesions. Japan. Heart J., 15, 209–210 (1974b).
Yamori, Y.; Horie, R.; Sato, M.; Akiguchi, I.; Ohtaka, M.; Nara, Y.; and Fukase, M. New Models of SHR for studies on stroke and atherogenesis. Clin. Exp. Pharmacol. Physiol., 199–203 (1976).
Yamori, Y.; Horie, R.; Akiguchi, I.; Nara, Y.; Ohtaka, M.; and Fukase, M. Pathogenic mechanisms and prevention of stroke in stroke-prone spontaneously hypertensive rats. In Hypertension and Brain Mechanism, W. de Jong, A. P. Provoost, and A. P. Shapiro, eds. Progress in Brain Research 47 (1977a), pp. 217–234.
Yamori, Y.; Horie, R.; Ohtaka, M.; Nara, Y.; Ohta, K.; Okamoto, K.; Handa, H.; and Fukase, M. Pathogenic approach to the prophylaxis of stroke and atherogenesis in SHR. In Spontaneous Hypertension: Its Pathogenesis and Complications. DHEW Publication No. (NIH) 77–1179 (1977b), pp. 269–278.
Yamori, Y.; Horie, R.; Ikeda, K.; Nara, Y.; and Lovenberg, W. Prophylactic effect of dietary protein on stroke and its mechanisms. In Prophylactic Approach to Hypertensive Diseases, Y. Yamori, W. Lovenberg, and E. Freis, eds. Raven Press, New York, pp. 497–504 (1979a).
Yamori, Y.; Iritani, N.; Nara, Y.; Horie, R.; Ohtaka, M.; and Ooshima, A. Hypertension and atherogenesis in animal models—A new aspect on the relationship. Japan. Heart J., 20 (Suppl.), 760–761 (1979b).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Spectrum Publications, Inc.
About this chapter
Cite this chapter
Yamori, Y., Nara, Y., Horie, R., Ooshima, A., Lovenberg, W. (1981). Pathophysiological Role of Taurine in Blood Pressure Regulation in Stroke-Prone Spontaneously Hypertensive Rats (SHR). In: Schaffer, S.W., Baskin, S.I., Kocsis, J.J. (eds) The Effects of Taurine on Excitable Tissues. Monographs of the Physiological Society of Philadelphia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8093-8_27
Download citation
DOI: https://doi.org/10.1007/978-94-009-8093-8_27
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8095-2
Online ISBN: 978-94-009-8093-8
eBook Packages: Springer Book Archive