Pathophysiological Role of Taurine in Blood Pressure Regulation in Stroke-Prone Spontaneously Hypertensive Rats (SHR)
Stroke-prone spontaneously hypertensive rats (SHRSP), which were established by selective breeding (Yamori et al., 1974a; Okamoto et al., 1974), develop severe hypertension and cerebrovascular lesions in more than 90% of the population (Yamori et al., 1976). These SHRSP, as well as spontaneously hypertensive rats (SHR), are regarded as the best models to date for studies on the pathogenesis and prevention of the spontaneously developing hypertensive diseases observed in man (Yamori and Okamoto, 1974; Folkow et al., 1973).
KeywordsSevere Hypertension Pathophysiological Role High Protein Diet Stroke Incidence Intraventricular Injection
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