Abstract
Pharmacology is one of the oldest of the medical sciences. For much of its history, however, pharmacology was concerned almost exclusively with pharmacodynamics, i.e. what drugs do to the body — rather than with pharmacokinetics, i.e. what the body does to drugs. This aspect of pharmacology can, to a large extent, be said to date from the studies by Williams on drug metabolism and the appearance of his classic monograph on detoxication mechanisms. Studies on pharmacokinetics were hindered, even in those rare instances in which they might have been considered necessary, by the lack of suitable methods for measuring drugs in biological fluids and for following their metabolism and secretion.
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References
Marks, V., Lindup, W. E. and Baylis, E. M. (1973). Measurement of therapeutic agents in blood. Adv. Clin. Chem., 16, 47
Marks, V., Morris, B. A. and Teale, J. D. (1974). Pharmacology. Br. Med. Bull., 30, 80
Landon, J. and Moffat, A. C. (1976). The radioimmunoassay of drugs: a review. Analyst, 101, 225
Butler, V. P. (1975). Drug immunoassays. J. Immunol. Methods, 7, 1
Mould, G. P., Aherne, G. W., Morris, B. A., Teale, J. D. and Marks, V. (1977). Radioimmunoassay of drugs and its clinical application. Eur. J. Drug Metab. Pharmacol., 4, 171
Marks, V. (1979). New developments in immunoassays for therapeutic drug monitoring. In Schonfield, H., Brockman, R. W. and Hahn, F. E. (eds.) Antibiotics and Chemotherapy, pp. 16–26. ( Basel: Karger )
Marks, V., Mould, G. P., O’Sullivan, M. J. and Teale, J. D. (1980). Monitoring of drug disposition by immunoassay. In Bridges, J. W. and Chasseaud, L. F. (eds.) Progress in Drug Metabolism, Vol. 4, ( Chichester: Wiley )
Erlanger, B. F. (1973). Principles and methods for the preparation of drug protein conjugates for immunological studies. Pharmacol. Rev., 25, 271
Aherne, G. W. and Marks, V. (1979). Radioimmunoassay techniques. In Techniques in Metabolic Research, pp. B215, 1–19. ( Amsterdam: Elsevier )
Morris, B. A., Robinson, J. D., Piall, E., Aherne, G. W. and Marks, V. (1974). Development of a radioimmunoassay for morphine having minimal cross-reactivity with codeine. J. Endocrinol, 64, 6 P
Robinson, J. D., Morris, B. A., Piall, E. M., Aherne, G. W. and Marks, V. (1975). The use of rats in screening of drug protein conjugates for immunoreactivity. In Pasternak, G. A. (ed.) Radioimmunoassay in Clinical Biochemistry, pp. 101–11. ( London: Heyden )
Mould, G. P., Stout, G., Aherne, G. W. and Marks, V. (1978). Radioimmunoassay of amitriptyline and nortriptyline in body fluids. Ann. Clin. Biochem., 15, 221
Mould, G. P., Clough, J., Morris, B. A., Stout, G. and Marks, V. (1980). Radioimmunoassay of propranolol in plasma. Biopharmaceutics and Drug Disposition. (In press)
Vaitukaitis, J., Robbins, J. B., Nieschlag, E. and Ross, G. T. (1971). A method for producing specific antisera with small doses of immunogen. J. Clin. Endocrinol. Metab., 33, 988
Teale, J. D., Clough, J. M. and Marks, V. (1977). Radioimmunoassay of bleomycin in plasma and urine. Br. J. Cancer, 35, 822
Kamel, R. S., Landon, J. and Smith, D. S. (1979). Novel 1251-labelled nortriptyline derivatives and their use in liquid phase or magnetizable solid-phase second-antibody radioimmunoassays. Clin. Chem., 25, 1997
Al-Bassam, M. N., O’Sullivan, M. J., Gnemmi, E., Bridges, J. W. and Marks, V. (1978). Double-antibody enzyme-immunoassay for nortriptyline. Clin. Chem., 24, 1590
Miller, J. N., Lim, C. S. and Bridges, J. W. (1980). Fluorescamine and fluorescein as labels in energy-transfer immunoassay. Analyst, 105, 91
Bastiani, R. J. (1979). The EMIT® system: a commercially successful innovation. In Schonfeld, H., Brockman, R. W. and Hahn, F. E. (eds.) Antibiotics and Chemotherapy, pp. 89–97. ( Basel: Karger )
Marks, V. and Teale, J. D. (1979). The radioimmunoassay of cannabinoids: its clinical, pharmacological and forensic applications. In Nahas, G. G. and Paton, W. D. M. (eds.) Marihuana: Biological Effects. Analysis, Metabolism, Cellular Responses, Reproduction and Brain, pp. 81–88. ( Oxford and New York: Pergamon Press )
Williams, P. L., Moffat, A. C. and King, L. J. (1978). Combined high-pressure liquid chromatography and radioimmunoassay method for the quantitation of delta-9-tetrahydrocannabinol and some of its metabolites in human plasma. J. Chromatogr., 155, 273
De Graeve, J. (1980). Some considerations regarding drug determinations in biological fluids with physico-chemical methods. In Siest, G. and Young, D. S. (eds.) Drug Measurement and Drug Effects in Laboratory Health Science, pp. 2–19. ( Basel: Karger )
Reiss, W., Brechbuhler, S. and Dubois, J. P. (1979). Rational analysis of drugs in biological fluids with particular reference to the tricyclic antidepressants. In Bridges, J. W. and Chasseaud, L. F. (eds.) Progress in Drug Metabolism, Vol. 3, pp. 115–49. ( Chichester: Wiley )
Marks, V. (1979). Clinical monitoring of therapeutic drugs. Ann. Clin, Biochem., 16, 370
Richens, A. and Marks, V. (1981). Therapeutic Drug Monitoring ( Edinburgh: Churchill Livingstone )
Schneider, R. S., Bastiani, R. J., Leute, R. K., Rubenstein, K. E. and Ullman, E. F. (1974). Use of enzyme and spin-labelling in homogeneous immunochemical detection method. In Mule, S. J., Sunshine, I., Braude, M. and Willette, R. E. (eds.) Immunoassays for Drugs Subject to Abuse, pp. 45–74. ( Cleveland: CRC Press )
Wong, R. C., Burd, J. F., Carrico, R. J., Buckler, R. T., Thoma, J. and Boguslaski, R. C. (1979). Substrate-labelled fluorescent immunoassay for phenytoin in human serum. Clin. Chem., 25, 686
Aherne, G. W., Marks, V., Morris, B. A., Piall, E. M., Robinson, J. D. and Twycross, R. G. (1975). The measurement of serum morphine levels by radioimmunoassay following oral administration of diamorphine or morphine. Br. J. Pharmacol., 54, 228 p
Baylis, E. M., Hall, M. S., Lewis, G. and Marks, V. (1972). Effects of renal function on plasma digoxin levels in elderly ambulant patients in domiciliary practice. Br. Med. J., 1, 338
Juel, R. (1979). The 1978 College of American Pathologists Therapeutic Drug Monitoring Interlaboratory Survey Program. Am. J. Clin. Pathol., 72, 306
American Association for Clinical Chemistry (1980). Therapeutic Drug Monitoring: Continuing Education and Quality Control Program. ( Washington: AACC )
Marks, V., O’Sullivan, M. J., Al-Bassam, M. N. and Bridges, J. W. (1978). A double antibody enzyme-immunoassay for methotrexate. In Pal, S. B. (ed.) Enzyme Labelled Immunoassay of Hormones and Drugs, pp. 419–28. ( Berlin: De Gruyter )
Ngowi, F. (1979). Development of an enzyme immunoassay for measuring 6-alphamethylprednisolone in biological fluids. MSc Thesis, University of Surrey
Teale, J. D., Clough, J. M., King, L. J., Marks, V., Williams, P. L. and Moffat, A. C. (1977). The incidence of cannabinoids in fatally injured drivers: an investigation by radioimmunoassay and high pressure liquid chromatography. J. Forens. Sci. Soc., 17, 177
Marks, V. and Fry, D. E. (1977). Detection and measurement of drugs in biological fluids: their relevance to the problem of drug abuse. In Glatt, M. M. (ed.) Drug Dependence: Current Problems and Issues, pp. 295–327 ( Lancaster: MTP Press )
Morris, D. L., Rawson, D., Ellis, P. B., Hornby, W. E., Schroeder, H. R., Boguslaski, R. C. and Carrico, R. J. (1979). Specific binding assays with a prosthetic group as label. Ann. Clin. Biochem., Suppl. 1, 25
Schroeder, H. R., Vogelhut, P.O., Carrico, R. J., Boguslaski, R. C. and Buckler, R. T. (1976). Competitive protein binding assay for biotin monitored by chemiluminescence. Anal. Chem., 48, 1933
Luster, M. I., Albro, P. W., Chase, K., Clark, G. and McKinney, J. D. (1978). Radioimmunoassay for mono-(2-ethylhexyl) phthalate in unextracted plasma. Clin. Chem., 24, 429
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Marks, V. (1981). Immunoassays in Pharmacology and Toxicology. In: Voller, A., Bartlett, A., Bidwell, D. (eds) Immunoassays for the 80s. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8054-9_17
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DOI: https://doi.org/10.1007/978-94-009-8054-9_17
Publisher Name: Springer, Dordrecht
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