Abstract
Orotic acid is relatively insoluble compound but some of its salts and derivatives are more soluble and therapeutically highly active [424–432]. The clearance of orotic acid approaches that of creatinine [433], and during drug-induced orotic aciduria it exceeds glomerular filtration [434]. There is evidence that even high doses of orotic acid are not deleterious to human individuals except that they may occasionally obstruct urine flow by forming crystalline deposits [435].
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Čihák, A., Reutter, W. (1980). Orotic Acid in Human Therapy. In: Orotic Acid. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8043-3_9
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DOI: https://doi.org/10.1007/978-94-009-8043-3_9
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