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Orotic Acid in Human Therapy

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Orotic Acid

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Abstract

Orotic acid is relatively insoluble compound but some of its salts and derivatives are more soluble and therapeutically highly active [424–432]. The clearance of orotic acid approaches that of creatinine [433], and during drug-induced orotic aciduria it exceeds glomerular filtration [434]. There is evidence that even high doses of orotic acid are not deleterious to human individuals except that they may occasionally obstruct urine flow by forming crystalline deposits [435].

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References

  1. Wildhirt, E. Ther. Umsch., 19, 387 (1962)

    PubMed  CAS  Google Scholar 

  2. Zimmer, V. Arztl. Prax., 23, 3411 (1971)

    Google Scholar 

  3. Birkmayer, W. and Rosmanith, H. Muench. Med. Wochenschr., 113, 387 (1971)

    CAS  Google Scholar 

  4. Prokop, L. Wien. Med. Wochenschr., 121, 399 (1971)

    PubMed  CAS  Google Scholar 

  5. Hapke, H. J., Sterner, W., Heisler, E. and Brauer, H. Farmaco, 26, 692 (1971)

    CAS  Google Scholar 

  6. Nieper, H. A. Z. Praeklin. Geriatr., 6, 127 (1974)

    Google Scholar 

  7. Nieper, H. A. Z. Praeklin. Geriatr., 8, 184 (1974)

    Google Scholar 

  8. Nieper, H. A. Z. Praeklin. Geriatr., 9, 200 (1974)

    Google Scholar 

  9. Unarova, S. A. Dokl. Akad. Nauk Tadzh. SSR., 18, 64 (1975)

    CAS  Google Scholar 

  10. Weissman, S. M., Eisen, A. Z., Fallon, H., Lewis, M. and Karon, M. J. Clin. Invest., 41, 1546 (1962)

    Article  PubMed  CAS  Google Scholar 

  11. Cardoso, S. S., Calabresi, P. and Handschumacher, R. E. Cancer Res., 21, 1551 (1961)

    PubMed  CAS  Google Scholar 

  12. Smith, L. H., Huguley, C. M. and Bain, J. A. The Metabolic Basis of Inherited Disease. J. B. Stanbury, J. B. Wyngaarden and D. S. Fredrickson (eds), p. 1003. (McGraw Hill) (1972)

    Google Scholar 

  13. Hinkel, G. K. and Richter, K. Pädiatr. Grenzgeb., 12, 215 (1973)

    PubMed  CAS  Google Scholar 

  14. Walther, H., Meyer, F. P. and Koehler, E. Zentralbl. Pharm., Pharmakother. Laboratoriumsdiagn., 115, 615 (1976)

    CAS  Google Scholar 

  15. Hinkel, G. K. and Le Petit, G. Paediatr. Grenzgeb., 12, 63 (1973)

    CAS  Google Scholar 

  16. Stomonyakova, S., Novachev, D. and Todorova, K. Pediatriya (Sofia), 15, 44 (1976)

    CAS  Google Scholar 

  17. Ivanov, V. R., Ivanova, L. S. and Dubnikova, L. A. Farmakol. Reparative Regener., 3, 68 (1977)

    Google Scholar 

  18. Nieper, H. A. Agressologie, 10, 349 (1969)

    CAS  Google Scholar 

  19. Nieper, H. A. Agressologie, 12, 401 (1971)

    CAS  Google Scholar 

  20. Nieper, H. A. Geriatrie, 4, 82 (1973)

    Google Scholar 

  21. Rundles, R. W. and Brewer, S. S. Blood, 13, 99 (1958)

    PubMed  CAS  Google Scholar 

  22. Kelley, W. N., Greene, M. L., Fox, J. H., Rosenbloom, F. M., Levy, R. I. and Seegmiller, J. E. Metab. Clin. Exp., 19, 1025 (1970)

    Article  PubMed  CAS  Google Scholar 

  23. Dergachev, V. V., Pivovarova, G. H., Khamaganova, T. G. and Shaginian, E. V. Sov. Med., 33, 78 (1970)

    PubMed  CAS  Google Scholar 

  24. Wenzel, E. Wien. Med. Wochenschr., 120, 226 (1971)

    Google Scholar 

  25. Ignatjev, M. V. Kardiologia, 9, 91 (1969)

    Google Scholar 

  26. Zharov, E. I. Kardiologia, 11, 15 (1971)

    CAS  Google Scholar 

  27. Simonson, E. and Berman, R. Am. Heart J., 86, 117 (1973)

    Article  PubMed  CAS  Google Scholar 

  28. Pogosova, A. V. and Belenky, E. E. Vopr. Med. Khim., 15, 343 (1969)

    PubMed  CAS  Google Scholar 

  29. Belenky, E. E., Sokolov, I. K., Tunitskaya, T. A. and Teplova, N. P. Farmakol. Toksikol. 34, 472 (1971)

    Google Scholar 

  30. Kleimenova, N. N., Alekseeva, S. P. and Belenky, E. E. Byull. Eksp. Biol. Med. 75, 105 (1973)

    Article  CAS  Google Scholar 

  31. Belenky, E. E., Sokolov, I. K., Lantsberg, L. A., Tunitskaya, T. A. and Kalugina, G. E. Farmakol. Toksikol., 36, 301 (1973)

    Google Scholar 

  32. Nikolaeva, L. F., Cherpachenko, N. M., Veselova, S. A. and Sokolova, R. I. Circ. Res. Suppl., 3, 202 (1974)

    Google Scholar 

  33. Zharov, E. I., Markovskaya, G. I. and Iurasov, V. S. Kardiologia, 8, 59 (1968)

    CAS  Google Scholar 

  34. Mikunis, R. I. and Morozova, R. Z. Kardiologia, 10, 102 (1970)

    CAS  Google Scholar 

  35. Villanyi, P., Votin, J. and Rahlfs, V. Wien. Med. Wochenschr., 120, 76 (1970)

    PubMed  CAS  Google Scholar 

  36. Szelényi, I., Sós, J., Rigo, J. and Surtya, M. Dtsch. Med. J., 22, 1405 and 1409 (1970)

    Google Scholar 

  37. Nemesánszky, E., Pavlik, G. and Szelényi, I. Arzneim. Forsch., 21, 791 (1971)

    Google Scholar 

  38. Donohoe, J. A., Williams, J. F., Kolos, G. and Hickie, J. B. Aust. N. Z. J. Med., 4, 542 (1974)

    Article  PubMed  CAS  Google Scholar 

  39. Williams, J. F., Donohoe, J. A., Lykke, A. and Kolos, G. Aust. N. Z.J. Med., 6, 60 (1976)

    Article  PubMed  Google Scholar 

  40. Mítová, M. and Bednařík, B. Scr. Med. Fac. Med. Univ. Brun. Purkynianae, 49, 259 (1976)

    Google Scholar 

  41. Matsuda, I. and Shirahata, T. Tohoku J. Exp. Med., 90, 133 (1966)

    Article  PubMed  CAS  Google Scholar 

  42. Kintzel, H.-W., Hinkel, G. K. and Schwarze, R. Acta Paediatr. Scand., 60, 1 (1971)

    Article  PubMed  CAS  Google Scholar 

  43. Schwarze, R., Kintzel, H.-W. and Hinkel, G. K. Acta Paediatr. Scand., 60, 705 (1971)

    Article  PubMed  CAS  Google Scholar 

  44. Gray, D. W. G. and Mowat, A. P. Arch. Dis. Child., 46, 123 (1971)

    Article  PubMed  CAS  Google Scholar 

  45. Kintzel, H.-W., Braun, W., Hinkel, G. K., Koslowski, H. and Schwarze, R. Acta Paediatr. Scand., 61, 703 (1972)

    Article  PubMed  CAS  Google Scholar 

  46. Hinkel, G. K., Schwarze, R. and Kintzel, H.-W. Acta Paediatr. Acad. Sci. Hung., 13, 367 (1972)

    PubMed  CAS  Google Scholar 

  47. Hinkel, G. K., Schwarze, R. and Kintzel, H.-W. Schweiz. Med. Wochenschr., 102, 331 (1972)

    PubMed  CAS  Google Scholar 

  48. Brodersen, R. Acta Paediatr. Scand. Suppl., 159, 15 (1965)

    Article  Google Scholar 

  49. Beck, K. and Falk, H. Liver Research. J. Vandenbroucke, Tijdschrift voor Gastroenterologie, Antwerpen 1967

    Google Scholar 

  50. Cachin, M., Alagille, D. Presse Med., 75, 859 (1967)

    PubMed  CAS  Google Scholar 

  51. Hinkel, G. K., Kemmer, C., Kintzel, H.-W., Roschlau, G. and Schwarze, R. Kinderaerztl. Prax., 38, 247 (1970)

    PubMed  CAS  Google Scholar 

  52. Hinkel, G. K., Kintzel, H.-W. and Schwarze, R. Kinderaerztl. Prax., 38, 323 (1970)

    PubMed  CAS  Google Scholar 

  53. Mowat, A. Arch. Dis. Child., 46, 397 (1971)

    Article  PubMed  CAS  Google Scholar 

  54. Hinkel, G. K., Kintzel, H.-W. and Schwarze, R. Dtsch. Gesundheitwesen, 27, 2414 (1972)

    CAS  Google Scholar 

  55. Krukow, N. and Brodersen, R. Acta Paediatr. Scand., 61, 697 (1972)

    Article  PubMed  CAS  Google Scholar 

  56. Händel, A., Hinkel, G. K., Kintzel, H.-W. and Schwarze, R. Paediatr. Paedol. 8, 307 (1973)

    Google Scholar 

  57. Cutillo, S., Meloni, T. and Dore, A. Acta Paediatr. Scand., 63, 143 (1974)

    Article  PubMed  CAS  Google Scholar 

  58. Lindenau, E., Böttcher, M., Bunke, H., Jung, U., Kalz, M., Klinger, W., Weh, L. and Gmyrek, F. Dtsch. Gesundheitwesen, 33, 26 (1978)

    Google Scholar 

  59. Rössing, P., Eberhard, H. and Brandenburg, W. Dtsch. Med. J., 7, 201 (1956)

    PubMed  Google Scholar 

  60. Dotti, F. and Bonetti, G. Riforma Med., 72, 666 (1958)

    PubMed  CAS  Google Scholar 

  61. Baldini, N. Attual. Diet. 4, 20 (1959)

    Google Scholar 

  62. Nissen, K. Landarzt Heft, 9, 337 (1961)

    Google Scholar 

  63. Kobayashi, K., Tabe, K., Sasaki, I. and Nakamura, T., Asian Med. J., 6, 1089 (1963)

    Google Scholar 

  64. Kubonoya, J., Kimura, M. and Hongo, A. Asian Med. J., 7, 196 (1964)

    Google Scholar 

  65. Yamada, T., Yamaguchi, M., Kuroiwa, S. and Ito, M. Asian Med. J., 8, 357 (1965)

    Google Scholar 

  66. Wildhirt, E. and Selmair, H. Muench. Med. Wochenschr., 109, 887 (1967)

    CAS  Google Scholar 

  67. Chanoine, F. Acta Gastroenterol. Belg., 32, 383 (1969)

    PubMed  CAS  Google Scholar 

  68. Riede, U. N., Strässle, H., Bianchi, L. and Rohr, H. P. Exp. Mol. Pathol. 15, 271 (1971)

    Article  PubMed  CAS  Google Scholar 

  69. Negret, J. P. Bordeaux. Med., 5, 973 (1972)

    CAS  Google Scholar 

  70. Heinrich, H. C. Med. Welt., 35, 1791 (1966)

    Google Scholar 

  71. Heinrich, H. C. Muench. Med. Wochenschr., 110, 2311 (1968)

    CAS  Google Scholar 

  72. Heinrich, H. C. Aerztl. Prax., 26, 65 (1974)

    Google Scholar 

  73. Wildhirt, E. Prax. Kurier, 12 10 (1967)

    Google Scholar 

  74. Wildhirt, E. Z. Praktsch. Med. 83, 1 (1970)

    Google Scholar 

  75. Wildhirt, E. Informierte Arzt., 4, 18 (1976)

    Google Scholar 

  76. Beckmann, K., Brügel, H., Mertz, D. P. Dtsch. Med. Wochenschr., 81, 573 (1956)

    Article  PubMed  CAS  Google Scholar 

  77. Riemann, D. Fortschr. Med., 32, 1317 (1970)

    Google Scholar 

  78. Rona, L., Doczy, P. and Marros, T. Aerztl. Prax., 22, 39 (1970)

    Google Scholar 

  79. Brunner, G., Vido, I., Perings, E. and Grünwälder, H. Arch. Pharm., 274, 325 (1972)

    Article  CAS  Google Scholar 

  80. Wallnöfer, H. Muench. Med. Wochenschr., 114, 186 (1972)

    Google Scholar 

  81. Lie, T. S., Nakano, H., Gappa, P., Böhmer, F. and Ebata, H. Leber Magen Darm., 7, 361 (1974)

    Google Scholar 

  82. Hirsch, W. and Smerlings, H. Ther. Ggw., 115, 1719 (1976)

    PubMed  CAS  Google Scholar 

  83. Ohlen, J. Prax. Kurier, 49, 6 (1977)

    Google Scholar 

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Authors and Affiliations

  1. Institute of Organic Chemistry and Biochemistry, Czechoslovakia Academy of Sciences Prague, Czechoslovakia

    Alois Čihák PhD

  2. Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany

    Werner Reutter MD

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  1. Alois Čihák PhD
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  2. Werner Reutter MD
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© 1980 A. Čihák and W. Reutter

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Čihák, A., Reutter, W. (1980). Orotic Acid in Human Therapy. In: Orotic Acid. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8043-3_9

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  • DOI: https://doi.org/10.1007/978-94-009-8043-3_9

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