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Orotic Acid pp 35-40 | Cite as

Physiological Effects

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Abstract

Increasing experimental evidence indicates an important role of orotic acid in various cellular processes taking place in different types of cells and organisms. Orotic acid has been shown to stimulate the phagocytic activity of leukocytes [340–342] and of the reticuloendothelial system [343] by a process which can be abolished by pretreatment with hydrocortisone. Vitamin B12 and folic acid were found to strengthen the normalizing action of orotic acid on the haemopoiesis of animals subjected to a long-term exposure to toxic substances in low dose [344,345]. Orotic acid at a dose of 100 mg/kg body weight suppressed in rats the inhibitory action of thiophosphamide on blood formation [346].

Keywords

Orotic Acid Magnesium Salt Enchondral Ossification Ammonia Poisoning Experimental Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© A. Čihák and W. Reutter 1980

Authors and Affiliations

  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovakia Academy of Sciences PragueCzechoslovakia
  2. 2.Institut für Molekularbiologie und Biochemie der Freien UniversitätBerlinGermany

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