Abstract
The administration of a purified diet supplemented with 1% orotic acid induces in rats a rapid accumulation of lipids in the liver [290]. Such an effect is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change [291,292] detected in rats given orotic acid is an increase in the pool of uridine nucleotides paralleled by a concomitant reduction of the level of adenine nucleotides and the oxidized and reduced forms of NAD.
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Čihák, A., Reutter, W. (1980). Induction of Fatty Liver in Rats. In: Orotic Acid. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8043-3_7
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DOI: https://doi.org/10.1007/978-94-009-8043-3_7
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