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Orotic Acid pp 31-34 | Cite as

Induction of Fatty Liver in Rats

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Abstract

The administration of a purified diet supplemented with 1% orotic acid induces in rats a rapid accumulation of lipids in the liver [290]. Such an effect is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change [291,292] detected in rats given orotic acid is an increase in the pool of uridine nucleotides paralleled by a concomitant reduction of the level of adenine nucleotides and the oxidized and reduced forms of NAD.

Keywords

Fatty Liver Adenine Nucleotide Orotic Acid Acid Fatty Liver Choline Deficient Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 290.
    Standerfer, S. B. and Handler, P. Proc. Soc. Exp. Biol. Med., 90, 270 (1955)PubMedGoogle Scholar
  2. 291.
    Creasey, W. A., Hankin, L. and Handschumacher, R. E. J. Biol. Chem., 236, 2064 (1961)PubMedGoogle Scholar
  3. 292.
    Von Euler, L. H., Rubin, R. J. and Handschumacher, R. E. J. Biol. Chem., 238, 2464 (1963)Google Scholar
  4. 293.
    Sidransky, H. and Verney, E. Am. J. Pathol., 46, 1007 (1965)PubMedGoogle Scholar
  5. 294.
    Handschumacher, R. E., Creasey, W. A., Jaffe, J. J., Pasternak, C. A. and Hankin, L. Proc. Natl. Acad. Sci. USA, 46, 178 (1960)PubMedCrossRefGoogle Scholar
  6. 295.
    Rajalakshmi, S. and Handschumacher, R. E. Biochim. Biophys. Acta, 155, 317 (1968)PubMedGoogle Scholar
  7. 296.
    Kelley, W. N., Fox, J. and Wyngaarden, J. B. Biochim. Biophys. Acta, 215, 512 (1970)PubMedGoogle Scholar
  8. 297.
    Jatlow, P., Adams, W. R. and Handschumacher, R. E. Am. J. Pathol., 47, 125 (1966)Google Scholar
  9. 298.
    Novikoff, A. B., Roheim, P. S. and Quintana, N. Lab. Invest., 15, 27 (1966)Google Scholar
  10. 299.
    Windmueller, H. G., Levy, R. I. and Spaeth, A. E. Adv. Exp. Med. Biol., 4, 365 (1969)Google Scholar
  11. 300.
    Windmueller, H. G. and Levy, R. I. J. Biol. Chem., 242, 2246 (1967)PubMedGoogle Scholar
  12. 301.
    Roheim, P. S., Miller, L. and Eder, H. A. J. Biol. Chem., 240, 2994 (1965)PubMedGoogle Scholar
  13. 302.
    Roheim, P. S., Switzer, S., Girard, A. and Eder, H. A. Biochem. Biophys. Res. Commun., 20, 416 (1965)PubMedCrossRefGoogle Scholar
  14. 303.
    Bloomfield, R. A., Letter, A. A. and Wilson, R. P. Biochim. Biophys. Acta, 187, 266 (1969)PubMedGoogle Scholar
  15. 304.
    Kruski, A. W. and Narayan, K. A. Int. J. Biochem., 7, 635 (1976)CrossRefGoogle Scholar
  16. 305.
    Valli, E. A., Sarma, D. S. R. and Sarma, P. S. Indian J. Biochem., 5, 120 (1968)Google Scholar
  17. 306.
    Kinsella, J. E. Biochim. Biophys. Acta, 137, 205 (1967)PubMedGoogle Scholar
  18. 307.
    Windmueller, H. G. J. Biol. Chem., 239, 530 (1964)PubMedGoogle Scholar
  19. 308.
    Hayano, K., Tsubone, T., Azuma, I. and Yamamura, Y. J. Biochem., 52, 379 (1962)PubMedGoogle Scholar
  20. 309.
    Windmueller, H. G. and Von Euler, L. H. Proc. Soc. Exp. Biol. Med., 136, 98 (1971)PubMedGoogle Scholar
  21. 310.
    Elwood, J. C., Richert, D. A. and Westerfeld, W. W. Biochem. Pharmacol., 21, 1127 (1972)PubMedCrossRefGoogle Scholar
  22. 311.
    Rajalakshmi, S., Sarma, D. S. R. and Sarma, P. S. Biochem. J., 80, 375 (1961)PubMedGoogle Scholar
  23. 312.
    Marchetti, M., Puddu, P. and Caldarera, C. M. Biochem. J., 92, 46 (1964)PubMedGoogle Scholar
  24. 313.
    Windmueller, H. G. and Spaeth, A. E. J. Biol. Chem., 240, 4398 (1965)PubMedGoogle Scholar
  25. 314.
    Roheim, P. S., Switzer, S., Girard, A. and Eder, H. A. Lab. Invest., 15, 21 (1966)Google Scholar
  26. 315.
    Klain, G. J. Biochim. Biophys. Acta, 144, 174 (1967)PubMedGoogle Scholar
  27. 316.
    Kinsella, J. E. Can. J. Biochem., 45, 1206 (1967)CrossRefGoogle Scholar
  28. 317.
    Zakim, D. Fed. Proc. Fed. Am. Soc. Exp. Biol., 26, 412 (1967)Google Scholar
  29. 318.
    Von Euler, L. H. and Windmueller, H. G. Proc. Soc. Exp. Biol. Med., 125, 1251 (1967)Google Scholar
  30. 319.
    Porta, E. A., Monning, C. and Hartroft, N. S. Arch. Pathol., 86, 217 (1968)PubMedGoogle Scholar
  31. 320.
    Simon, J. B., Scheig, R. and Klatskin, G. Proc. Soc. Exp. Biol. Med., 129, 874 (1968)PubMedGoogle Scholar
  32. 321.
    Klain, G. J., Sullivan, F. J. and Meikle, A. W. J. Nutr., 100, 1431 (1970)PubMedGoogle Scholar
  33. 322.
    Petzold, H., Storch, H. and Hohlfeld, R. Z. Ges. Inn. Med. Ihre Grenzgeb., 25, 697 (1970)Google Scholar
  34. 323.
    Vaishwanar, I. and Jiddewar, G. G. Indian J. Biochem., 7, 214 (1970)PubMedGoogle Scholar
  35. 324.
    Torrielli, M. V., Dianzani, M. U. and Ugazio, G. Life Sci., 10, 99 (1971)CrossRefGoogle Scholar
  36. 325.
    Pottenger, L. A. and Getz, G. S. J. Lipid Res., 12, 450 (1971)PubMedGoogle Scholar
  37. 326.
    Bloom, R. J. and Westerfeld, W. W. Arch. Biochem. Biophys., 145, 669 (1971)PubMedCrossRefGoogle Scholar
  38. 327.
    Witting, L. A. J. Lipid Res., 13, 27 (1972)PubMedGoogle Scholar
  39. 328.
    Hamuro, Y. Endocrinology, 90, 200 (1972)PubMedCrossRefGoogle Scholar
  40. 329.
    Nassi, P., Cappugi, G., Niccoli, A. and Ramponi, G. Physiol. Chem. Phys., 5, 109 (1973)Google Scholar
  41. 330.
    Pinelli, A. and Colombo, A. Riv. Farmacol. Ter., 4, 363 (1973)Google Scholar
  42. 331.
    Feo, C. and Garcon, E. Biomedicine, 19, 61 (1973)PubMedGoogle Scholar
  43. 332.
    Irsigler, K., Flegel, U., Kühn, P. and Schubert, H. Int. J. Clin. Pharmacol. Ther. Toxicol., 8, 85 (1973)Google Scholar
  44. 333.
    Pottenger, L. A., Frazier, L. E., Dubien, L. H., Getz, G. S. and Wissler, R. W. Biochem. Biophys. Res. Commun., 54, 770 (1973)PubMedCrossRefGoogle Scholar
  45. 334.
    Novikoff, P. M., Roheim, P. S., Novikoff, A. B. and Edelstein, D. Lab. Invest., 30, 732 (1974)PubMedGoogle Scholar
  46. 335.
    Okonkwo, P. O. and Kinsella, J. E. Experientia, 30, 993 (1974)PubMedCrossRefGoogle Scholar
  47. 336.
    Negishi, I. and Aizawa, Y. Jap. J. Pharmacol., 25, 345 (1975)PubMedCrossRefGoogle Scholar
  48. 337.
    Novikoff, P. M. and Edelstein, D. Lab. Invest., 36, 215 (1977)PubMedGoogle Scholar
  49. 338.
    Sabesin, S. M., Frase, S. and Ragland, J. B. Lab. Invest., 37, 127 (1977)PubMedGoogle Scholar
  50. 339.
    Rajalakshmi, S., Adams, W. R. and Handschumacher, R. E. J. Cell. Biol., 41, 625 (1969)PubMedCrossRefGoogle Scholar

Copyright information

© A. Čihák and W. Reutter 1980

Authors and Affiliations

  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovakia Academy of Sciences PragueCzechoslovakia
  2. 2.Institut für Molekularbiologie und Biochemie der Freien UniversitätBerlinGermany

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