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Induction of Fatty Liver in Rats

  • Chapter
Orotic Acid

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Abstract

The administration of a purified diet supplemented with 1% orotic acid induces in rats a rapid accumulation of lipids in the liver [290]. Such an effect is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change [291,292] detected in rats given orotic acid is an increase in the pool of uridine nucleotides paralleled by a concomitant reduction of the level of adenine nucleotides and the oxidized and reduced forms of NAD.

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Authors and Affiliations

  1. Institute of Organic Chemistry and Biochemistry, Czechoslovakia Academy of Sciences Prague, Czechoslovakia

    Alois Čihák PhD

  2. Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany

    Werner Reutter MD

Authors
  1. Alois Čihák PhD
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  2. Werner Reutter MD
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© 1980 A. Čihák and W. Reutter

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Čihák, A., Reutter, W. (1980). Induction of Fatty Liver in Rats. In: Orotic Acid. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8043-3_7

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  • DOI: https://doi.org/10.1007/978-94-009-8043-3_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8045-7

  • Online ISBN: 978-94-009-8043-3

  • eBook Packages: Springer Book Archive

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