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Orotic Acid pp 18-22 | Cite as

Efficiency and Regulation of Pyrimidine Synthesis

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Abstract

There are only a few studies dealing with the cellular uptake of orotic acid. The incorporation of orotic acid into whole cells can be stimulated more than 90-fold by a combination of PRPP and a heat labile factor [150], probably orotate phosphoribosyltransferase. It is assumed [151] that the enzyme attaches to the cell membrane and in the presence of external orotic acid and PRPP leads to the formation of internal orotidine 5′-phosphate. In bacteria the orotate is taken up similarly [151] by a process of group translocation across the membrane involving the participation of orotate phosphoribosyltransferase and requiring PRPP.

Keywords

Orotic Acid Carbamoyl Phosphate Pyrimidine Nucleotide Carbamoyl Phosphate Synthetase Pyrimidine Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© A. Čihák and W. Reutter 1980

Authors and Affiliations

  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovakia Academy of Sciences PragueCzechoslovakia
  2. 2.Institut für Molekularbiologie und Biochemie der Freien UniversitätBerlinGermany

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