Summary
The thymus produces a nonapeptide capable of inducing T cell surface markers and T cell functions in immature lymphoid cells. This peptide is found partly bound to a carrier protein in the circulation from where it has been isolated (hence its name of serum thymic factor (FTS)). Immunofluorescence studies using an antibody raised against synthetic FTS has shown that it is produced by the thymic epithelium. Its mode of action at the cellular level involves the binding to specific high affinity receptors.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hooper, J. A., Mc Daniel, M. C., Thurman, G. B., Cohen, G. H., Schulof, R. S. & Goldstein, A. L., 1975. Ann. N.Y. Acad. Sci. 249: 125–138.
Cohen, G., Hooper, J. A. & Goldstein, A. L., 1975. Ann. N.Y. Acad. Sci. 249: 145–153.
Wara, D. W., Goldstein, A. L., Doyle, W. & Amman, A. J., 1975. N. Engl. J. Med. 292: 70–74.
Thurman, G. B. & Goldstein, A. L., 1975. In: ‘The biological activity of thymic hormones’ Van Bekkum, D. W., ed.), pp. 261–264, Kooyker Sci. Publ., Rotterdam.
Thurman, G. B., Ahmed, A., Strong, D. M., Gershwin, M. E., Steinberg, A. D. & Goldstein, A. L., 1975. Transpl. Proc. 7: 299–303.
Horowitz, S. W., Borcherding, A. V., Morrthy, R., Chesney, H., Schulte-Wisserman, R., Hong, C. & Goldstein, A. L., 1977. Science 197: 999–1001.
Pazmino, N. H., Ihle, J. N. & Goldstein, A. L., 1978. J. Exp. Med. 147: 708–718.
Goldstein, A. L., Low, T. L. K., Mac Adoo, M., McClure, J., Thurman, G., Rossio, J., Lai, C., Chang, D., Wang, S., Harvey, C., Ramel, A. H. & Meinhofer, J., 1977. Proc. Nat. Acad. Sci. (Wash) 74: 725–729.
Low, T. L. K., Thurman, G. B., Chincarini, C., Mc Clure, J. E., Marshall, G. D., Hu, S. K. & Goldstein, A. L., 1979. Ann. N.Y. Acad. Sci. 332: 348.
Goldstein, G., 1975. Ann. N.Y. Acad. Sci. 249: 177–185.
Schlesinger, D. H. & Goldstein, G., 1975. Cell 5: 361–365.
Schlesinger, D. H., Goldstein, G., Scheid, M. & Boyse, E. A., 1975. Cell 5: 367–371.
Goldstein, G., Scheid, M., Boyse, E. A., Schlesinger, D. H. & Van Wauwe, J., 1979. Science 204: 1309–1310.
Law, C. & Goldstein, G., 1980. J. Immunol. 124: 1861–1865.
Trainin, N., Small, M., Zipori, D., Umiel, T., Kook, A. I. & Rotter, V., 1975. The biological activity of thymic hormones (Van Bekkum, D. W., ed.), pp. 117–144, Kooyker Sci. Publ., Rotterdam.
Umiel, T. & Trainin, N., 1975. Eur. J. Immunol. 5: 85–88.
Carnaud, C., Ilfeld, D., Brook, I. & Trainin, N., 1973. J. Exp. Med. 138: 1521–1532.
Rotter, V. & Trainin, N. 1975. Cell. Immunol. 16: 413–421.
Kook, A. I. & Trainin, N., 1974. J. exp. Med. 139: 193–207.
Bach, J. F., Dardenne, M., Goldstein, A., Guha, A. & White, A., 1971. Proc. Natl. Acad. Sci. U.S.A. 68: 2734–2738.
Komuro, K. & Boyse, E. A., 1973. Lancet 1: 740–743.
Bach, J. F., & Dardenne, M., 1973. Immunology 25: 353–366.
Bach, J. F., Dardenne, M. & Pléau, J. M., 1977. Nature 266: 55–56.
Dardenne, M., Papiernik, M., Bach, J. F. & Stutman, O., 1974. Immunology 27: 299–304.
Dardenne, M., Pléau, J. M., Blouquit, Y. & Bach, J. F., 1980. Clin. Exp. Immunol. 42: 477–482.
Monier, J. C., Dardenne, M., Pléau, J. M., Schmitt, D., Deschaux, P. & Bach, J. F., 1981. Clin. Exp. Immunol 42: 470–476.
Pléau, J. M., Dardenne, M., Blouquit, Y. & Bach, J. F., 1977. J. Biol. Chem. 252: 8045–8047.
Pléau, J. M., Fuentes, V., Morgat, J. L. & Bach, J. F., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 2861–2865.
Dardenne, M., Pléau, J. M., Man, N. K. & Bach, J. F., 1977. J. Biol. Chem. 252: 8040–8044.
Dardenne, M. & Bach, J. F., 1975. The Biological activity of thymic hormones (Van Bekkum, D. W., ed.), pp. 235–243, Kooyker Sci. Publ., Rotterdam.
Bricas, E., Martinez, J., Blanot, D., Auger, G., Dardenne, M., Pléau, J. M. & Bach, J. F., 1977. ‘Peptides’, Proc. 5th Amer. Peptide Symposium (Goodman, M. & Meinhofer, J., eds.) pp. 564–567, J. Wiley & Sons.
Blanot, D., Martinez, J., Auger, G. & Bricas, E., 1979. Int. J. Peptide Protein Res. 14: 41–56.
Bach, J. F., Bach, M. A., Blanot, D., Bricas, E., Charreire, J., Dardenne, M., Fournier, C. & Pléau, J. M., 1978. Bull. Inst. Pasteur 76: 325–398.
Dardenne, M., Pléau, J. M. & Bach, J. F., 1980. Eur. J. Immunol. 10: 83–86.
Burton, P., Iden, D., Mitchel, K. & White, A., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 823–827.
Incefy, G., Mertelsmann, R., Iwata, K., Dardenne, M., Bach, J. F. & Good, R. A., 1980. Clin. Exp. Immunol. 40: 396–406.
Charreire, J. & Bach, J. F., 1975. Proc. Natl. Acad. Sci. U.S.A. 72: 3201–3205.
Bach, M. A., 1977. J. Immunol. 119: 641–647.
Erard, D., Charreire, J., Auffredou, M. T., Galanaud, P. & Bach, J. F., 1979. J. Immuol. 123: 1573–1576.
Bach, M. A., Fournier, C. & Bach, J. F., 1979. In: ‘12th International Leukocyte Conference’ (Quastel, M. R., ed.), pp. 177–188, Academic Press, New York.
Lepault, F., Dardenne, M. & Frindel, E., 1979. Eur. J. Immunol. 9: 661–664.
Bardos, P., Carnaud, C. & Bach, J. F., 1980. C.R. Acad. Sci. Paris 289: Série D., 1251–1254.
Pléau, J. M., Pasques, D., Bach, J. F., Gros, C. & Dray, F., 1977. Radioimmunoassay and related procedures in medicine, Vol. II, pp. 505–510, I. A.E.A. Vienna.
Lesniak, M., Gordon, P., Roth, J. & Gavin, J., 1974. J. Biol. Chem. 249: 1664–1668.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1981 Martinus Nijhoff/ Dr W. Junk Publishers, The Hague
About this chapter
Cite this chapter
Pleau, JM., Dardenne, M., Bach, JF. (1981). The serum thymic factor (FTS). In: Najjar, V.A. (eds) Immunologically Active Peptides. Developments in Molecular and Cellular Biochemistry, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8030-3_8
Download citation
DOI: https://doi.org/10.1007/978-94-009-8030-3_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8032-7
Online ISBN: 978-94-009-8030-3
eBook Packages: Springer Book Archive