Summary
The first two sections give a historical introduction describing the identification of a muramyl-dipeptide as the smallest adjuvant active moiety capable of replacing whole killed mycobacterial cells in Freund’s complete adjuvant. This molecule, MDP (for muramyl-dipeptide = N-acetyl-muramyl-L-alanyl-D-iso-glutamine) was synthesized and shown to be fully active.
The third section describes in detail the various derivatives and analogues of MDP which have been synthesized and characterizes their main properties, such as adjuvant activity, stimulation of non-specific resistance to infections and pyrogenicity.
The fourth section gives a summary of the biological properties of MDP and its derivatives; these are reported under the following headings:
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Adjuvant and related activities (qualitative changes in antibody synthesis, immunogenicity of MDP, autoimmune responses, MDP as adjuvant for vaccines, induction of cell mediated immunity)
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Modulation of host resistance to tumours and to infections (antitumour activity of MDP and its derivatives, non-specific resistance to infection)
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Mitogenic activity, polyclonal activation, pyrogenicity of MDP.
The fifth section ‘Target cells and mechanism of action’ relates in vivo and in vitro experiments and the action of MDP on macrophages. Finally, the metabolic fate of MDP and derivatives is discussed.
The conclusions of this review try to foresee the future applications of MDP and its derivatives, as components of vaccines, as anticancer and antiparasitic agents and ends with a word of caution concerning the possible side effects of the intensive use of immunomodulators in human beings.
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References
Freund, J., 1956. Advances in Tuberculogy, 7: 130–148.
Lederer, E., Adam, A., Ciorbaru, R., Petit, J. F. & Wietzerbin, J., 1975. Molecular & Cellular Biochem. 7: 87–104. Petit, J. F. & Lederer, E., 1978. Relations between structure and function in the prokaryotic cell. Symp. Soc. Gen. Biol. 28: 177–199.
Lederer, E., 1977. Med. Chem. V, pp. 257–279, Elsevier, Amsterdam.
White, R. G., Bernstock, L., Johns, R. G. & Lederer, E., 1958. Immunol. 1: 54–66. White, R. G., Jollès, P., Samour, D. & Lederer, E., 1964. Immunol. 7: 158–171.
Azuma, I., Kishimoto, Y., Yamamura, Y. & Petit, J. F., 1971. Japan J. Microbiol. 15: 193–197.
Adam, A., Ciorbaru, R., Petit, J. F. & Lederer, E., 1972. Proc. Natl. Acad. Sci. U.S.A. 69: 851–854.
Migliore-Samour, D. & Jollès, P., 1972. Biochem. Bio- phys. Res. Comm. 66: 1316–1322.
Hiu, I. J., 1972. Nature New Biology 238: 241–242.
Adam, A., Ciorbaru, R., Petit, J. F., Lederer, E., Chedid, L., Lamensans, A., Parant, F., Parant, M., Rosselet, J. P. & Berger, F. M., 1973. Infect. Immun. 7: 855–861.
Ciorbaru, R., Petit, J. F., Lederer, E., Zisssman, E., Bona, C. & Chedid, L., 1976. Infect. Immun. 13: 1084–1089.
Ciorbaru, R., Adam, A., Petit, J. F., Lederer, E., Bona, C. & Chedid, L., 1975. Infect. Immun. 11: 257–264.
Brochier, J., Bona, C., Ciorbaru, R., Revillard, J. P. & Chedid, L., 1976. J. Immunol. 117: 1434–1439.
Barot-Ciorbaru, R., Wietzerbin, J., Petit, J. F., Chedid, L., Falcoff, E. & Lederer, E., 1978. Infect. Immun. 19: 353–356.
Barot-Ciorbaru, R., Yakota, Y., Petit, J. F., Chedid, L. & Atanasiu, P., 1979. Ann. Microbiol. 130B: 263–269.
Stewart-Tull, D. E. S., Shimono, T., Kotani, S., Kato, M., Ogawa, Y., Yamamura, Y., Koga, T. & Pearson, C. M., 1975. Immunol. 29: 1–15.
Kumazawa, Y., Shibusawa, A., Suzuki, T. & Mizumoe, K., 1976. Japan J. Microbiol. 20: 183–190.
Nauciel, C., Fleck, J., Martin, J. P. & Mock, M., 1973. C.R. Acad. Sci. (série D) 276: 3499–3500.
Nauciel, C., Fleck, J., Martin, J. P., Mock, M. & Nguyên- Huy, H., 1974. Europ. J. Immunol. 4: 352–357.
Adam, A., Amar, C., Lederer, E., Petit, J. F. & Vilkas, E., 1974. C.R. Acad. Sci. (série D) 278: 799–801.
Adam, A., Ciorbaru, R., Ellouz, F., Petit, J. F. & Lederer, E., 1974. Biochem. Biophys. Res. Comm. 56: 561–567.
Kotani, S., Watanabe, Y., Shimono, T., Kinoshita, F., Narita, T., Kato, K., Stewart-Tull, D. E. S., Morisaki, I., Yokogawa, K. & Kawata, S., 1975. Biken J. 18: 93–104.
Nauciel, C., Fleck, J., Mock, M. & Martin, J. P., 1973. C.R. Acad. Sci. (serie D) 277: 2841–2844.
Adam, A., Petit, J. F., Wietzerbin-Falszpan, J., Sinaӱ, P., Thomas, D. W. & Lederer, E., 1969. FEBS Letters 4: 87–92.
Azuma, I., Thomas, D. W., Adam, A., Ghuysen, J. M., Bonaly, R., Petit, J. F. & Lederer, E., 1970. Biochim. Biophys. Acta 208: 444–451.
Ellouz, F., Adam, A., Ciorbaru, R. & Lederer, E., 1974. Biochem. Biophys. Res. Comm. 59: 1317–1325.
Adam, A., Ellouz, F., Ciorbaru, R., Petit, J. F. & Lederer, E., 1975. Z. Immutätsforsch 149: 341–348.
Ellouz, F., 1975. Doctoral Dissertation, Fac. Pharm. Chatenay-Malabry.
Merser, C., Sinaӱ, P. & Adam, A., 1975. Biochem. Biophys. Res. Comm. 66, 1316–1322.
Kotani, S., Watanabe, Y., Kinoshita, F., Shimono, T., Morisaki, I., Shiba, T., Kusumoto, S., Tarumi, Y. & Ikenaka, K., 1975. Biken J. 18: 105–112.
Kotani, S., Narita, T., Stewart-Tull, D. E. S., Shimono, T., Watanabe, Y., Kato, K. & Iwata, S., 1975. Biken J. 18: 77–92.
Kotani, S., Watanabe, Y., Kinoshita, P., Schleifer, K. H.& Perkins, H. R., 1977. Biken J. 20: 1–4.
Chedid, L., Audibert, F. & Johnson, A. G., 1978. Prog. Allergy 25: 63–105.
Dukor, P., Tarcsay, L. & Baschang, G., 1979. Annu. Rep. Med. Chem. 14: 146–166.
Parant, M., 1979. Springer Semin. Immunopathol. 2: 101–118.
Lederer, E., 1980. J. Med. Chem. 23: 819–825.
Kusumoto, S., Tarumi, Y., Ikenaka, K. & Shiba, T., 1976. Bull. Chem. Soc. Japan 49: 544–539.
Lefrancier, P., Choay, J., Derrien, M. & Lederman, I., 1977. Int. J. Peptide Protein Res. 9: 249–257. Lefrancier, P., Derrien, M., Lederman, I., Nief, F., Choay, J. & Lederer, E., 1978. Int. J. Peptide Protein Res. 11: 289–296. Lefrancier, P., Petitou, M., Level, M., Derrien, M., Choay, J. & Lederer, E., 1979. Int. J. Peptide Protein Res. 14: 437–444.
Lefrancier, P. & Lederer, E., 1981. Progress Chem. Org. Nat. Prod. 40: 1–47. Springer, Wien.
Audibert, F., Parant, M., Damais, C., Lefrancier, P., Derrien, M., Choay, J. & Chedid, L., 1980. Biochem. Biophys. Res. Comm. 96: 915–923.
Audibert, F., Parant, M., Chedid, L., Level, M., Lefrancier, P., Choay, J. & Lederer, E., 1981. Unpublished.
Chedid, L., Audibert, F., Lefrancier, P., Choay, J. & Lederer, E., 1976. Proc. Natl. Acad. Sci. USA 73: 2472–2475.
Audibert, F., Chedid, L., Lefrancier, P. & Choay, J., 1976. Cell. Immunol. 21: 243–249.
Azuma, I., Sugimura, K., Yamamura, Y., Kusumoto, S., Tarumi, Y. & Shiba, T., 1976. Jap. J. Microbiol. 20: 63–68.
Azuma, I., Sugimura, K., Taniyama, T., Yamawaki, M., Yamamura, Y., Kusumoto, S., Okada, S. & Shiba, T., 1976. Infect. Immun. 14: 18–27.
Adam, A., Devys, M., Souvannavong, V., Lefrancier, P., Choay, J. & Lederer, E., 1976. Biochem. Biophys. Res. Comm. 72: 339–346.
Hasegawa, A., Kaneda, Y., Amano, M., Kiso, M. & Azuma, I., 1978. J. Agricol. Biol. Chem. 42: 2187–2189.
Durette, P. L., Meitzner, E. P. & Shen, T. Y., 1979. Carbohyd. Res. 77: C1–C4.
Tsujimoto, M., Kinoshita, F., Okunaga, T., Kotani, S., Kusumoto, S., Yamamoto, K. & Shiba, T., 1979. Microbiol. Immunol. 23: 933–936.
Durette, P. L., Meitzner, E. P. & Shen, T. Y., 1979. Tetrahed. Lett. 4013–4016.
Nagai, Y., Akiyama, K., Kotani, S., Watanabe, Y., Shimono, T., Shiba, T. & Kusumoto, S., 1978. Cell. Immunol. 35: 168–172.
Parant, M., Damais, C., Audibert, F., Parant, E., Chedid, L., Sache, E., Lefrancier, P., Choay, J. & Lederer, E., 1978. J. Infect. Dis. 138: 378–386.
Chedid, L., Parant, M., Parant, F., Lefrancier, P., Choay, J. & Lederer, E., 1977. Proc. Natl. Acad. Sci. USA 74: 2089–2093.
Kiso, M., Kaneda, Y., Okumura, H., Hasegawa, A., Azuma, I. & Yamamura, Y., 1980. Carbohyd. Res. 79: C17–C19.
Hasegawa, A., Okumura, H., Kiso, M., Azuma, I. & Yamamura, Y., 1980. Carbohyd. Res. 79: C20–C23.
Kotani, S., Kinoshita, F., Morisaki, I., Shimono, T., Okunaga, T., Takada, H., Tsujimoto, M., Watanabe, Y., Kato, K., Shiba, T., Kusumoto, S. & Okada, S., 1977. Biken J. 20: 95–103.
Koga, T., Maeda, K., Onoue, K., Kato, K. & Kotani, S., 1979. Mol. Immunol. 16: 153–163.
Kotani, S., Watanabe, Y., Kinoshita, F., Morisaki, I., Kato, K., Shiba, T., Kusumoto, S., Tarumi, Y. & Ikenaka, K., 1977. Biken J. 20: 39–45.
Chedid, L., Parant, M. & Parant, F., 1977. Cr. Hebd. Séanc. Acad. Sci. Paris 284 D: 405–408.
Audibert, F., Chedid, L., Lefrancier, P., Choay, J. & Lederer, E., 1977. Ann. Immunol (Inst. Pasteur) 128 c.: 653–661.
Mašek, K., Zaoral, M., Jesek, J. & Krchnak, V., 1979. Experientia 35: 1397–1398.
Kotani, S., Kinoshita, F., Watanabe, Y., Morisaki, I., Shimono, T., Kato, K., Shiba, T., Ikenaka, K. & Tarumi, Y., 1977. Biken J. 20: 125–130.
Azuma, I., Sugimura, K., Yamawaki, M., Uemiya, M., Kusumoto, S., Okada, S., Shiba, T. & Yamamura, Y., 1978. Infect. Immun. 20: 600–607.
Yamamura, Y., Azuma, I., Sugimura, K., Yamawaki, M., Uemiya, M., Kusumoto, S., Okada, S. & Shiba, T., 1976. Gann. 67: 867–877.
Uemiya, M., Saiki, I., Kusoma, T., Azuma, I. & Yamamura, Y., 1979. Microbiol. Immunol. 23: 821–823.
Uemiya, M., Sugimura, K., Kusama, T., Saiki, I., Yamawaki, M., Azuma, I. & Yamamura, Y., 1979. Infect. Immun. 24: 83–89.
Azuma, L, Sugimura, K., Taniyama, T., Yamawaki, M., Yamamura, Y., Kusumoto, S., Okada, S. & Shiba, T., 1976. Infect. Immun. 14: 18–27.
Azuma, I., Yamawaki, M., Uemiya, M., Saiki, I., Panio, Y., Kobayashi, S., Fukuda, T., Imada, I. & Yamamura, Y., 1979. Gann. 76: 847–848.
Takada, H., Tsujimoto, M., Kotani, S., Kusumoto, S., Inage, M., Shiba, T., Nagao, S., Yano, I., Kawata, S. & Yokogawa, K., 1979. Infect. Immun. 25: 645–652.
Pabst, M. J., Cummings, N. P., Shiba, T., Kusumoto, S. & Kotani, S., 1980. Infect. Immun. 29: 617–622.
Parant,M.,Audibert,F.,Chedid,L.,Level,M.,Lefrancier, P., Choay, J. & Lederer, E., 1980. Infect. Immun. 27: 825–831.
Migliore-Samour, D., Bouchaudon, J., Floch, F., Zerial, A., Ninet, L., Werner, G. H. & Jollès, P., 1979. C.R. Acad. Sci. Paris, série D 289: 473–476.
Audibert, F., Heymer, B., Gros, C., Schleifer, K. H., Seidl, P. H. & Chedid, L., 1978. J. Immunol. 121: 1219–1222.
Parant, M., Parant, F., Chedid, L.,Yapo, A., Petit, J. F. & Lederer, E., 1979. Int. J. Immunopharmacol. 1: 35–41.
Drapier, J. C., Lemaire, G., Tenu, J. P. & Petit, J. F., 1979. The Molecular Basis of Immune Cell Function (J. G. Kaplan, Ed.), Elsevier-North Holland, Biomedical Press, Amsterdam.
Reichert, C. M., Carelli, C., Jolivet, M., Audibert, F., Lefrancier, P. & Chedid, L., 1980. Mol. Immunol. 17: 357–363.
Chedid, L., Parant, M., Parant, F., Audibert, L., Lefrancier, P., Choay, J. & Sela, M„ 1979. Proc. Natl. Acad. Sci. USA 76: 6557–6561.
Baschang, G., Dietrich, F. M., Gisler, R., Hartmann, A., Stanek, J. & Tarcsay, L., 1978. Swiss Patent 2035/78, Feb. 24.
Sela, M. & Mozes, E., 1979. Springer Semin. Immunopathol. 2: 119–132.
Wilkinson, P. C. & White, R. G., 1966. Immunology 11: 229–241.
Souvannavong, V. T., Adam, A. & Lederer, E., 1978. Infect. Immun. 19: 966–971.
Tanaka, A., Saito, R., Sugiyama, K., Morisaki, I., Kotani, S., Kusumoto, S. & Shiba, T., 1977. Infect. Immun. 15: 332–334.
Löwy, I., Theze, J. & Chedid, L., 1980. J. Immunol. 124: 100–104.
Leclerc, C., Juy, D., Bourgeois, E. & Chedid, L., 1979. Cell. Immunol. 45: 199–206.
Löwy, I., Bona, C. & Chedid, L., 1977. Cell. Immunol. 29: 195–199.
Souvannavong, V.& Adam, A., 1980. Eur. J. Immunol. 10: 654–656.
Leclerc, C., Audibert, F. & Chedid, L., 1978. Immunology 35: 963–970.
Ohkuni, H., Norose, Y., Hayama, M., Kimura, Y., Kotani, S., Shiba, T., Kusumoto, S., Yokogawa, K. & Kawata, S., 1977. Biken J. 20: 131–136.
Ohkuni, H., Norose, Y., Ohta, M., Hayama, M., Kimura, Y., Tsujimoto, M., Kotani, S., Shiba, T., Kusomoto, S., Yokogawa, K. & Kawata, S., 1979. Infect. Immun. 24: 313–318.
Heymer, B., Finger, H. & Wirsing, C. H., 1978. Zeit. Immunität Forsch. 155: 87–92.
Kishimoto, T., Hirai, Y., Nakanishi, K., Azuma, I., Nagematsu, A. & Yamamura, Y., 1979. J. Immunol. 123: 2709–2715.
Audibert, F., Heymer, B., Gros, C., Schleifer, K. H.,Seidl, P. H. & Chedid, L., 1978. J. Immunol. 121: 1219–1222.
Krause, R. M., 1975. Z. Immun. Forsch. Exp. Ther. 149S: 136–150.
Chedid, L., Carelli, C. & Audibert, F., 1979. J. Reticuloendothelial. Soc. 26S: 631–641.
Chedid, L. & Audibert, F., 1976. In: P. A. Miescher, Vllth International Symposium of Immunopathology, BadSchache, pp. 382–396.
Toullet, F., Audibert, F., Voisin, G. A. & Chedid, L., 1977. Ann. Inst. Pasteur, Paris, 128C: 267–269.
Kozak, Y. de, Audibert, F., Thillaye, B., Chedid, L. & Faure, J. P., 1979. Ann. Immunol. ( Institut Pasteur ) 130C: 29–32.
Kohashi, O., Kotani, S., Shiba, T. & Ozawa, A., 1979. Infect. Immun. 26: 690–697.
Nagao, S. & Tanaka, A., 1980. Infect. Immun. 28: 624–626.
Nagai, Y., Akiyama, K., Suzuki, K., Kotani, S., Watanabe, Y., Shimono, T., Shiba, T., Kusumoto, K., Ikuta, F. & Takeda, S., 1978. Cell. Immunol. 35: 158–167.
Nagai, Y., Akiyama, K., Kotani, S., Watanabe, Y., Shimono, T., Shiba, T. & Kusumoto, S., 1978. Cell. Immunol. 35: 168–172.
Audibert, F., Chedid, L. & Hannoun, C., 1977. C.R. Hebd. Séances Acad. Sci. Ser. D 285: 467–470.
Webster, R. G., Glezen, W. P., Hannoun, C. & Laver, W. G., 1977. J. Immunol. 119: 2073–2077.
Okunaga, T., Kotani, S., Tada, Z., Kato, M., Kubo, T., Kusomoto, S., Inage, M. & Shiba, T., 1980. Nippon Saikingaku Zasshi Japan 35: 112.
Reese, R. T., Trager, W., Jensen, J. B., Miller, D. A. & Tantravahi, R., 1978. Proc. Natl. Acad. Sci. USA 75: 5665–5668.
Mitchell, G. H., Richards, W. H. G., Voller, A., Dietrich, F. M. & Dukor, P., 1979. Bulletin World Health Organization 57: 189–197.
Siddiqui, W. A., Taylor, D. W., Kan, S. Ch., Kramer, K., Richmond-Crum, S. M., Kotani, S., Shiba, T. & Kusumoto, S., 1978. Science 201: 1237–1239.
Tribouley, J., Tribouley-Duret, J. & Appriou, M., 1979. C.R. Soc. Biol. 173: 1046–1049.
Matter, A., 1979. Cancer Immunol. Immunother. 6: 202–210.
Hibbs, J. B., Remington, J. S. & Stewart, C. C., 1980. Pharmac. Ther. 8: 37–69.
102a.Lederer, E., 1979. Springer Semin. Immunopathol. 2: 133–148.
Rapp, H. J., 1980. Isr. J. Med. Sci. 9: 366–374.
Zbar, B., Ribi, E., Meyer, T., Azuma, I. & Rapp, H. J., 1974. J. Natl. Cancer Inst. 52: 1571–1577.
Ribi, E., Milner, C., Granger, D. L., Kelly, M. T., Yamamoto, K., Brehmer, W., Parker, R., Smith, R. F. & Strain, S. M., 1976. Ann. New York Acad. Sci. 277: 228–238.
McLaughlin, C. A., Strain, S. M., Bickel, W. D., Goren, M. B., Azuma, I., Milner, K., Cantrell, J. L. & Ribi, E., 1978. Cancer Immunol. Immunother. 4: 61–68.
McLaughlin, C. A., Schwartzman, S. M., Horner, B. L., Jones, G. H., Moffat, J. G., Nestor, J. J. Jr. & Tegg, D., 1980. Science 208: 415–416.
Yarkoni, E., Lederer, E. & Rapp, H. J., 1981. Infect. Immun. 32: 273–276.
Yarkoni, E. & Rapp, H. J., 1980. Infect. Immun. 28: 881–886.
Yarkoni, E., Rapp, H. J., Polonsky, J. & Lederer, E., 1978. Int. J. Cancer 22: 564–569.
Parant, M., Parant, F., Chedid, L. & LeMinor, L., 1975. Ann. Immunol. ( Paris ) 126C: 321–326.
Parant, M., Parant, F. & Chedid, L., 1978. Proc. Natl. Acad. Sci. USA 75: 3395–3399.
Chedid, L., 1978. 7th Int. Congress Pharmacol. Paris, July.
Sackmann, W. & Dietrich, F. M., Abstract Int. Symp. on ‘Infections in the Immunocompromised host’, June 1980 Veldhoven (Eindhoven) The Netherlands.
Dietrich, F. M., Sackman, W., Zak, O. & Dukor, P., 1980. Curr. Chemother. Infect. Dis. Proc. Int. Congr. Chemother. 11th 1979. 2: 1730–1732.
Tobe, K., Nagata, Y. & Ogawa, H., 1980. Nippon Saikingaku Zasshi Japan 35: 175.
116a.Kujima, K., Tomioka, M., Nagao, S., Imat, K. & Tanaka, A., 1980. Nippon Saikingaku Zasshi Japan 35: 287.
Mathews, T. R. & Fraser-Smith, E. B., 1980. Curr. Chemother. Infect. Dis., Proc. Int. Congr. Chemother. 11th 1979, Eds. J. D. Nelson & C. Grassi, Am. Soc. Microbiol. 2: 1734–1735.
Finger, H. & Wirsing Von König, C. H., 1980. Infect. Immun. 27: 288–291.
Kierszenbaum, F. & Ferraresi, R. W., 1979. Infect. Immun. 25: 273–278.
Specter, S., Friedman, H. & Chedid, L., 1977. Proc. Soc. Exp. Biol. Med. 155: 349–352.
Damais, C., Parant, M., Chedid, L., Lefrancier, P. & Choay, J., 1978. Cell. Immunol. 35: 173–179.
Specter, S., Cimprich, R., Friedman, H. & Chedid, L., 1978. J. Immunol. 120: 487–491.
Watson, J. & Whitlock, C., 1978. J. Immunol. 121: 383–389.
Takada, H., Tsujimoto, M., Kotani, S., Kusumoto, S., Inage, M., Shida, T., Nagao, S., Yano, I., Kawata, S. & Yokogawa, K., 1979. Infect. Immun. 25: 645–652.
Damais, C., Parant, M. & Chedid, L., 1978. Antibiotics Chemother. 24: 19–29.
Möller, G., 1975. Transplant Rev. 23: 126–130.
Leclerc, C., Löwy, I. & Chedid, L., 1978. Cell. Immunol. 38: 286–293.
Löwy, I., Leclerc, C. & Chedid, L., 1980. Immunology 39: 441–450.
Löwy, I., Leclerc, C., Bourgeois, E. & Chedid, L., 1980. J. Immunol. 124: 320–325.
Kotani, S., Watanabe, Y., Shimono, T., Harada, K., Shiba, T., Kusumoto, S., Yokogawa, K. & Taniguchi, M., 1976. Biken J. 19: 9–13.
Dinarello, C. A., Elin, R. J., Chedid, L. & Wolff, S. M., 1978. J. Infect. Dis. 138: 760–767.
Wahl, S. M., Wahl, L. M., McCarthy, J. B. & Chedid, L., 1979. J. Immunol. 122: 2226–2231.
Parant, M., Riveau, G., Parant, F., Dinarello, C. A., Wolff, S. M. & Chedid, L., 1980. J. Infect. Dis. 124: 708–718.
Riveau, G., Masek, K., Parant, M. & Chedid, L., (1981) J. Exp. Med. 152: 869–877.
Masek,K., Kadlecova, O. & Petrovicky, P., 1980. Fever, Proc. Int. Symp. 1979 Ed. Lipton, J. M. Raven, New York, 123–130.
Prunet, J., Birrien, J. L., Panijel, J. & Liacopoulos, P., 1978. Cell. Immunol. 37: 151–161.
Sugimoto, M., Germain, R. N., Chedid, L. & Benacerraf, B., 1978. J. Immunol. 120: 980–982.
Leclerc, C., Juy, D. & Chedid, L., 1979. Cell. Immunol. 42: 336–343.
Fevrier, M., Birrien, J. L., Leclerc, C., Chedid, L. & Liacopoulos, P., 1978. Eur. J. Immunol. 8: 558–562.
Leclerc, C., Bourgeois, E. & Chedid, L., 1978. Immunol. Commun. 8: 55–64.
Lefkovits, I., 1972. Eur. J. Immunol. 2: 360–365.
Sugimura, K., Uemiya, M., Saiki, I., Azuma, I. & Yamamura, Y., 1979. Cell. Immunol. 43: 137–149.
Tanaka, A., Nagao, S., Saito, R., Kotani, S., Kusumoto, S. & Shela, T., 1977. Biochem. Biophys. Res. Comm. 77: 621–627.
Hadden, J. W., Englard, A., Sadlick, J. R. & Hadden, E. M., 1979. Int. J. Immunopharmac. 1: 17–27.
Pabst, M. J. & Johnston, R. B., 1980. J. Exp. Med. 151: 101–114.
Juy, C. & Chedid, L., 1975. Proc. Natl. Acad. Sci. USA 72: 4105–4109.
Tenu, J. P., Lederer, E. & Petit, J. F., 1980. Eur. J. Immunol. 10: 647–653.
Taniyama, T. & Holden, H. T., 1979. Cell. Immunol. 48: 369–374.
Yamamoto, Y., Nagao, S., Tanaka, A., Koga, T. & Onoue, K., 1978. Biochem. Biophys. Res. Comm. 80: 923–928.
Adam, A., Souvannavong, V. & Lederer, E., 1978. Biochem. Biophys. Res. Comm. 85: 684–690.
Takada, H., Tsujimoto, M., Kato, K., Kotani, S., Kusumoto, S., Inage, M., Shiba, T., Yono, I., Kawata, S. & Yokogawa, K., 1979. Infect. Immun. 25: 48–53.
Drapier, J. C., Lemaire, G. & Petit, J. F., 1980. In: Inflammation: Mechanisms and treatment (D. A. Willoughby, J. P. Giroud & N. Suartz, Eds), M.T.P. Press Ltd., Lancaster.
Staber, F. G., Gisler, R. H., Schumann, G., Tarcsay, L., Schäfli, E. & Dukor, P., 1978. Cell. Immunol. 37: 174–187.
Oppenheim, J. J., Tagawa, A., Chedid, L. & Mizel, S., 1980. Cell. Immunol. 50: 71–81.
Tomasic, J., Ladesic, B., Valinger, Z. & Hrsak, 1980. Biochim. Biophys. Acta 629: 77–82.
Gisler, R. H., Dietrich, F. M., Baschang, G., Brownbill, A., Schumann, G., Staber, F. G., Tarcsay, L., Wachsmuth, E. D. & Dukor, P., 1979. In: Drugs & Immune Responsiveness (J. L. Turk & Darien Parker, Eds.), MacMillan Press, New York, pp. 133–160.
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© 1981 Martinus Nijhoff/ Dr W. Junk Publishers, The Hague
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Adam, A., Petit, JF., Lefrancier, P., Lederer, E. (1981). Muramyl peptides. In: Najjar, V.A. (eds) Immunologically Active Peptides. Developments in Molecular and Cellular Biochemistry, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8030-3_5
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DOI: https://doi.org/10.1007/978-94-009-8030-3_5
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