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Bactericidal activity of tuftsin

  • Chapter
Immunologically Active Peptides

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 2))

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Summary

The biological activities of the phagocytosis stimulating tetrapeptide, Thr-Lys-Pro-Arg are discussed. A brief account on the stimulation by tuftsin of phagocytosis of various particles, including bacteria was reported. Stimulation of bactericidal activity by this tetrapeptide was investigated in vitro as well as in vivo. The potency of tuftsin to enhance blood clearing of Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Serratia marcescens by mouse peritoneal macrophages was demonstrated.

Bactericidal activity and effects of tuftsin on this phenomenon were studied in liver and spleen of mice. Tuftsin stimulates these activities. Same experiments were performed in infected leukemic mice by Serratia marcescens or Escherichia coli. Results on blood clearing and bactericidal activities in liver and spleen were reported and compared to those of healthy and leukemic untreated animals. Tuftsin was found to present interesting stimulatory effects on the bactericidal activity of phagocytes.

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References

  1. Winkelstein, J. A. & Drachman, R. H., 1974. Symposium on infectious disease. Pediatric Clinics of North America 21: 551–569.

    PubMed  CAS  Google Scholar 

  2. Fidalgo, B. V. & Najjar, V. A., 1967. Proc. Natl. Acad. Sci. U.S. 57: 957–964.

    Article  CAS  Google Scholar 

  3. Fidalgo, B. V. & Najjar, V. A., 1967. Biochemistry 6: 3386–3392.

    Article  PubMed  CAS  Google Scholar 

  4. Najjar, V. A., Fidalgo, B. V. & Stitt, E., 1968. Biochemistry 7: 2376–2379.

    Article  PubMed  CAS  Google Scholar 

  5. Nishioka, K., Satoh, P. S., Constantopoulos, A. & Najjar, V. A., 1973. Biochim. Biophys. Acta 310: 230–237.

    PubMed  CAS  Google Scholar 

  6. Najjar, V. A. & Nishioka, K., 1970. Nature 228: 672–673.

    Article  PubMed  CAS  Google Scholar 

  7. Nishioka, K., Constantopoulos, A., Satoh, P. S. & Najjar, V. A., 1972. Biochem. Biophys. Res. Comm. 47: 172–179.

    Article  PubMed  CAS  Google Scholar 

  8. Najjar, V. A., 1976. J. Pediat. 87: 1121–1124.

    Article  Google Scholar 

  9. Najjar, V. A., 1976. In: Biological Membranes (Chapman and Wallach, eds.). London, Academic Press, pp. 191–240.

    Google Scholar 

  10. Stossel, T. P., 1974. N. Engl. J. Med. 290: 774–780.

    Article  Google Scholar 

  11. Stossel, T. P., 1974. N. Engl. J. Med. 290: 833–839.

    Article  PubMed  CAS  Google Scholar 

  12. Baehner, R. L. & Nathan, D. G., 1968. N. Engl. J. Med. 278: 971–976.

    Article  PubMed  CAS  Google Scholar 

  13. Park, B. H., Figrig, S. M. & Smithwick, E. M., 1968. Lancet 2: 532–534.

    Article  PubMed  CAS  Google Scholar 

  14. Park, B. H. & Good, R. H., 1970. Lancet 2: 616.

    Article  PubMed  CAS  Google Scholar 

  15. Constantopoulos, A., Najjar, V. A. & Smith, J. W., 1972. J. Pediat. 80: 564–572.

    Article  PubMed  CAS  Google Scholar 

  16. Martinez, J., Winternitz, F. & Vindel, J., 1977. Eur. J. Med. Chem. 12: 511–516.

    CAS  Google Scholar 

  17. Najjar, V. A., 1980. Macrophages and Lymphocytes, Part A (Escobar, M. R. & Friedman, H., eds. ), pp. 131–147.

    Google Scholar 

  18. Najjar, V. A. & Constantopoulos, A., 1972. J. Reticuloendothel. Soc. 12: 197–215.

    PubMed  CAS  Google Scholar 

  19. Fridkin, M., Stabinsky, Y., Zakuth, V. & Spirer, Z., 1977. Peptides 1976 ( Loffet, A., ed. ), pp. 541–549.

    Google Scholar 

  20. Fridkin, M., Stabinsky, Y., Zakuth, V. & Spirer, Z., 1977. Biochim. Biophys. Acta 496: 203–211.

    PubMed  CAS  Google Scholar 

  21. Bar-Shavit, Z., Stabinsky, Y., Fridkin, M. & Goldman, R., 1979. J. Cell. Physiol. 100: 55–62.

    Article  PubMed  CAS  Google Scholar 

  22. Constantopoulos, A. & Najjar, V. A., 1972. Cytobios. 6: 97–100.

    CAS  Google Scholar 

  23. Spirer, A., Zakuth, V., Golander, A., Bogair, N. & Fridkin, M., 1975. J. Clin. Invest. 55: 198–200.

    Article  PubMed  CAS  Google Scholar 

  24. Van Furth, L., 1973. Handbook Exp. Immunol. 2:

    Google Scholar 

  25. Nair, R. M. G., Ponce, B. & Fudenberg, H. H., 1978. Immunochemistry 15: 901–907.

    Article  PubMed  CAS  Google Scholar 

  26. Chaudhuri, M. K. & Najjar, V. A., 1979. Analytical. Biochem. 95: 305–310.

    Article  CAS  Google Scholar 

  27. Yajima, H., Ogawa, H., Watanabe, H., Fujii, N., Kurobe, M. & Miyamoto, S., 1975. Chem. Pharm. Bull. 23: 371–374.

    CAS  Google Scholar 

  28. Najjar, V. A., 1974. Adv. Enzymol. 41: 129–178.

    PubMed  CAS  Google Scholar 

  29. Nishioka, K., Constantopoulos, A., Satoh, P. S., Mitchell, W. M. & Najjar, V. A., 1973. Biochim. Biophys. Acta 310: 217–229.

    PubMed  CAS  Google Scholar 

  30. Rauner, R. A., Schmidt, J. J. & Najjar, V. A., 1976. Mol. Cell. Biochem. 10: 77–80.

    Article  PubMed  CAS  Google Scholar 

  31. Hisatsune, K., Kobayashi, K., Nozaki, S. & Muramatsu, I., 1978. Microbiol. Immunol. 22: 581–584.

    PubMed  CAS  Google Scholar 

  32. Najjar, V. A., 1978. Expl. Cell. Biol. 46: 114–126.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Equipe de Recherche No. 195 CNRS, Ecole Nationale Supérieure de Chimie, 8, rue de l’Ecole Normale, 34075, Montpellier Cedex, France

    Jean Martinez & François Winternitz

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  1. Jean Martinez
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  2. François Winternitz
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V. A. Najjar

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© 1981 Martinus Nijhoff/ Dr W. Junk Publishers, The Hague

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Martinez, J., Winternitz, F. (1981). Bactericidal activity of tuftsin. In: Najjar, V.A. (eds) Immunologically Active Peptides. Developments in Molecular and Cellular Biochemistry, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8030-3_13

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  • DOI: https://doi.org/10.1007/978-94-009-8030-3_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8032-7

  • Online ISBN: 978-94-009-8030-3

  • eBook Packages: Springer Book Archive

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