Summary
Peritoneal macrophages from tuftsin or MDP-treated mice were tested for their cytostatic activity for tumor cell proliferation. Both substances are able to activate macrophages either after intravenous injection or after incubation in vitro with normal macrophages. But a stimulation as well as an inhibition of tumor cell growth can result from macrophage activation depending on the timing and dose injected. Restoration of the impaired cytostatic capacity of macrophages of mice observed with aging, is obtained by repeated administration of tuftsin. Normal and BCG-stimulated macrophages were examined for their regulatory activity on the proliferation of P815 tumor cells. Low density of macrophages per well determines a stimulation of target cell growth whether the macrophages are normal or activated. When the number of macrophages is increased, under conditions in which normal macrophages are not inhibitory. BCG stimulated macrophages exert already a strong cytostatic activity. At high macrophage content it appears that normal macrophages can also display an inhibitory activity. Macrophage-tumor cell interactions are highly dependent on the concentration and the state of activation of macrophages.
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References
Schultz, R. M., Papamatheakis, D., Luetzeler, J. & Chirigos, M. A., 1977. Cancer Res. 37: 3338 3347.
Mackaness, G. B., 1962. J. Exp. Med. 116: 381–388.
Mackaness, G. B., 1969. J. Exp. Med. 129: 973–985.
North, R. J., 1978. J. of Immunol. 121: 806–809.
Karnosky, M. L. & Lazdins, J. K., 1978. J. of Immunol. 121: 809 813.
Cohn, Z. A., 1978. J. of Immunol. 121: 813–816.
Hibbs, J. B., Lambert, L. H. & Remington, J. S., 1972. Proc. Soc. Exp. Biol. Med. 139: 1049 1052.
Martinez, J., Winternitz, F. & Vindel, J., 1980. Eur. J. Med. Chem., in the press.
Florentin, I., Bruley-Rosset, M., Kiger, N., Imbach, J. L., Winternitz, F. & Mathe, G., 1978. Cancer Immunol. Immunoth. 5: 21 1216.
Ellouz, F., Adam, A., Ciobaru, R. & Lederer, E., 1974. Biochem. Biophys. Res. Commun. 59: 1317–1325.
Juy, D. & Chedid, L., 1975. Proc. Natl. Acad. Sci. USA 72: 4105–4111.
Bruley-Rosset, M., Florentin, I., Khalil, A. M. & Mathe, G., 1976. Int. Arch. Allergy Appl. Immun. 51: 594–607.
Najjar, V. A. & Nishioka, K., 1970. Nature (London) 228–673.
Nishioka, K., 1979. Brit. J. Cancer 39: 342–345.
Hadden, J. W., Englard, A., Sadlik, J. R. & Hadden, E. M., 1979. Int. J. Immunopharmacol. 1: 17–27.
Alexander, P. & Evans, R., 1971. Nature New Biol. 232: 76–78.
Cheers, C. & Waller, R., 1975. J. of Immunol. 115: 844–847.
Nathan, C. F. & Terry, W. D., 1975. J. Exp. Med. 142: 887–902.
Goldman, R. & Bar-Shavit, Z., 1979. J. Natl. Cancer Inst. 63: 1009–1016.
Keller, R., 1974. Brit. J. Cancer 30: 401–415.
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© 1981 Martinus Nijhoff/ Dr W. Junk Publishers, The Hague
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Bruley-Rosset, M., Florentin, I., Mathé, G. (1981). Macrophage activation by tuftsin and muramyl-dipeptide. In: Najjar, V.A. (eds) Immunologically Active Peptides. Developments in Molecular and Cellular Biochemistry, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8030-3_11
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DOI: https://doi.org/10.1007/978-94-009-8030-3_11
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