A Forecast for Application of Cyclodextrins in the Pharma-Industry

  • Á. Stadler-Szőke
  • J. Szejtli
Part of the Advances in Inclusion Science book series (AIS, volume 1)


During the last decade a rapidly increasing activity was reflected in the number of papers and patents dedicated to the pharmaceutical application of CD-s.

The main results of these investigations should be summarised as follows:
  1. a./

    on account of solubility and toxicity reasons the β -CD — until now the only industrially produced CD — can be utilized in oral and rectal preparations

  2. b./

    the main features of complexation of active ingradients by β -CD are the stabilization of labile compounds and enhancement of bioavsilability

  3. c./

    the accumulated knowledge on this field allow to set limits with acceptable certainty to the group of drugs, which can be and which are worth of transformation into CD-complex.


Shape, size and hydrophobicity of molecules are the main factors in determining the complexability.

About 10 % of orally applied drugs — their active ingredient — seems to be complexable; about half of these cases one or other physical or chemical properties can be modified up to such an extent, which give reason of CD complexation.

Taking into account all factors, in at least 2 % of all actually produced tablets the presence of CD as complexing agent /or auxiliary substance/ is favourable. It means, that in a not too far future a several thousand ton fraction of the β -CD market might be consumed by the pharmaceutical industry for production of oral preparations.


Inclusion Complex Guest Molecule Anthranilic Acid Cyclodextrin Complexation Japan Patent 
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Copyright information

© Springer Science+Business Media Dordrecht 1982

Authors and Affiliations

  • Á. Stadler-Szőke
    • 1
  • J. Szejtli
    • 1
  1. 1.CHINOIN Pharmaceutical-Chemical WorksBudapestHungary

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