Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Plasma Fibronectin: Biochemical Properties and Clinical Relevance

  • Chapter
Bloodtransfusion and Problems of Bleeding

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 5))

  • 47 Accesses

Abstract

The reticuloendothelial system (RES) consists of a network of sessile and mobile mononuclear phagocytes which perform a variety of physiological functions with respect to host defense. Those fixed macrophages that reside in the liver and spleen and comprise the majority of the RES are uniquely located anatomically such that they can monitor the circulation and have been demonstrated to remove a variety of blood-borne toxic and particulate material of both endogenous and exogenous origin (37). These cells can selectively recognize and remove from the vascular compartment endogenously generated material including cell debris (26), denatured collagen (43), fibrin aggregates (23), and a variety of exogenous colloidal and particulate material including bacteria (4,16,34,41). Early studies involved in the evaluation of the activity of this system which is responsible for the removal of circulating particulate demonstrated that activation of the system as evidenced by an enhanced rate of removal of test particulate from the blood was associated with an increased resistance to a variety of pathophysiological situations such as traumatic injury (51), infection (34), and tumor growth (4). Conversely, depression of the clearance capacity of the system resulted in an increased sensitivity of experimental animals to the same pathological insults. Therefore, the concept that the RES was important in host defense processes became firmly established.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen, C., Saba, T.M., Molnar, J.: Isolation, purification and characterization of opsonic protein. J. Reticuloendothelial Soc. 13: 410, 1973.

    CAS  Google Scholar 

  2. Annest, S.J., Scovill, W.A., Blumenstock, F.A., Stratton, H.H., Newell, J.C., Paloski, W.H., Saba, T.M., Powers, S.R.: Increased creatinine clearance following cryoprecipitate infusion in trauma and surgical patients with decreased renal function. J. Trauma 20: 726, 1980.

    Article  CAS  PubMed  Google Scholar 

  3. Atherton, B.T., Hynes, R.O.: A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell 25: 133 1981.

    Article  CAS  PubMed  Google Scholar 

  4. Biozzi, B., Stiffel, C., Halpern, B.M., Manton, D.: Etude de la fonction phagocytaire du SRE au cours du développement de tumeurs expérimentales chez le rat et la souris. Ann. Inst. Pasteur. 94: 681, 1958.

    CAS  Google Scholar 

  5. Biozzi, G., Benacerraf, B., Halpern, B.N.: Quantitative study of the granulopectic activity of the reticuloendothelial system. II. A study of the kinetics of the granulopectic activity of the RES in relation to the dose of carbon injected. Relationship between the weight of the organs and their activity. Brit. J. Exp. Path. 34: 441, 1953.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Blumenstock, F.A., Saha, T.M.: Purification of alpha-2-opsonic glycoprotein from human serum and its measurement by immunoassay. J. Reticuloendothelial Soc. 23: 119, 1978.

    CAS  Google Scholar 

  7. Blumenstock, F.A., Saba, T.M., Weber, P., Cho, E.: Purification and biochemical characterization of a macrophage stimulated alpha2-globulin opsonic protein. J. Reticuloendothelial Soc. 19: 157, 1976.

    CAS  Google Scholar 

  8. Blumenstock, F.A., Saba, T.M., Weber, P., Laffin, R.: Biochemical and immunological characterization of human opsonic alpha-2-SB glycoprotein; Its identity with cold-insoluble globulin. J. Biol. Chem. 253: 4387, 1978.

    Google Scholar 

  9. Blumenstock, F.A., Weber, P.B., Saba, T.M.: Isolation and purification from rat serum of an alpha-2-opsonic glycoprotein. J. Biol. Chem. 252: 7156, 1977.

    CAS  PubMed  Google Scholar 

  10. Blumenstock, F.A., Weber, P., Saba, T.M., Laffin, R.: Electroimmunoassay of alpha-2-opsonic protein during reticuloendothelial blockade. Am. J. Physiol. 232: R80, 1977.

    CAS  PubMed  Google Scholar 

  11. Brodin, B., Bergham, L., Frigerg-Nielson, S., Nordstrom, H., Schildt, B.: Fibronectin in the treatment of septicemia - a preliminary report. Excerpta Medica. 7th World Congress of Anesthesiology. Hamburg, 1980, p. 504.

    Google Scholar 

  12. Dillon, B.C., Saba, T.M.: Starvation-induced hepatic phagocytic depression: Role of opsonic fibronectin and neutrophils in the distribution of blood-borne taphcloeoceus aureur. Abstracts of Association for Academic Surgery, 1981, p. 68.

    Google Scholar 

  13. Dillon, B.C., Saba, T.M., Cho, E., Lewis, E.: Opsonic fibronectin deficiency in the etiology of starvation induced reticuloendothelial phagocytic dysfunction. Exp. and Molec. Path. 36 (in press), 1982.

    Google Scholar 

  14. Di Luzio, N.R.: Macrophages, recognition factors and neoplasia. In: RES System. International Academy of Pathology Monograph. Baltimore, MD, Williams and Wilkins, 1975, p. 49.

    Google Scholar 

  15. Engel, J., Odermatt, E., Engel, A., Madri, J.A., Furthmayer, H., Rohde, H., Timpl, R.: Shapes, domain organization and flexibility of laminin in fibronectin. Two multi-functional proteins of the extracellular matrix. J. Molec. Biol. 150: 97, 1981.

    Article  CAS  PubMed  Google Scholar 

  16. Filkins, F.P.: Detoxification of endotoxin by leukocytes and macrophages. Proc. Soc. Exp. Biol. Med. 137: 1396, 1971.

    Article  CAS  PubMed  Google Scholar 

  17. Filkins, F.P., Chase, R.E., Smith, J.J.: Characteristics of a plasma factor governing carbon phagocytosis in the isolated per-fused rat liver. J. Reticuloendothelial Soc. 2: 287, 1965.

    CAS  Google Scholar 

  18. Graham, C.W., Blumenstock, F.A., Saha, T.M., Gotoff, S.: Labor modulates alpha-2-opsonic protein (2OP) for fixed macrophages. J. Reticuloendothelial Soc. 24: 31a, 1978.

    Google Scholar 

  19. Graham, C.W., Saba, T.M.: Opsonin in reticuloendothelial regulation during and following pregnancy. J. Reticuloendothelial Soc. 14: 121, 1973.

    CAS  Google Scholar 

  20. Jilek, F., Hormann, H.: Fibronectin (cold-insoluble globulin). VI. Influence of heparin and hyaluronic acid on the binding of native collagen. Hoppe-Seyler’s Z. Physiol. Chem. 360: 597, 1979.

    Article  CAS  Google Scholar 

  21. Kaplan, J.E., Saba, T.M.: Humoral deficiency and reticuloendothelial depression after traumatic shock. Am. J. Physiol. 230: 7, 1976

    CAS  PubMed  Google Scholar 

  22. Kaplan, J.E., Saba, T.M., Cho, E.: Serological modifications of reticuloendothelial capacity and altered resistance to traumatic shock. Circ. Shock 3: 203, 1976.

    Google Scholar 

  23. Kaplan, J.E.: The role of the reticuloendothelial system in control of hemostatic and thrombotic mechanisms. In: Pathophysiology of the Reticuloendothelial System. eds. B.M. Altura and T.M. Saba. Raven Press, New York, 1981, p. 111.

    Google Scholar 

  24. Lanser, M.E., Saba, T.M., Scovill, W.A.: Opsonic glycoprotein (plasma fibronectin) levels after burn injury: Relationship to extent of burn and development of

    Google Scholar 

  25. Manwaring, W.H., Coe, H.C.: Endothelial opsonins. J. Immunol. 1: 401, 1916.

    CAS  Google Scholar 

  26. Molnar, J., McLain, S., Allen, C., Laga, H., Gava, A., Gelder, R.: Specificity of a non-complement related opsonic protein. Biochem. Biophys. Acta 493: 37, 1977.

    CAS  PubMed  Google Scholar 

  27. Morrison, P.R., Edsall, J.T., Miller, S.G.: Preparation and properties of serum and plasma proteins. XVIII. The separation of purified fibrinogen from fraction I of human plasma. J. Am. Chem. Soc. 70: 3103, 1948.

    Article  CAS  PubMed  Google Scholar 

  28. Mosesson, M.W., Umfleet, R.A.: The cold-insoluble globulin of human plasma. I. Purification, primary characterization and relationship to fibrinogen and other cold-insoluble fraction components. J. Biol. Chem. 245: 572 8, 1970.

    Google Scholar 

  29. Mosher, D.F.: Changes in plasma cold-insoluble globulin concentration during experimental Rocky Mountain Spotted Fever infection in rhesus monkeys. Thromb. Res. 9: 37, 1976.

    Article  CAS  PubMed  Google Scholar 

  30. Mosher, D.F.: Cross-linking of cold-insoluble globulin by fibrin stabilizing factors. J. Biol. Chem. 250: 6614, 1976.

    Google Scholar 

  31. Mosher, D.F., Williams, E.M.: Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intra-vascular coagulation. J. Lab. Clin. Med. 91: 729, 1978.

    CAS  PubMed  Google Scholar 

  32. Ruoslahti, E., Vaheri, A.: Interaction of soluble fibroblast surface antigens with fibrinogen and fibrin. Identity with cold-insoluble globulin of human plasma. J. Exp. Med. 141: 497, 1975.

    Article  CAS  PubMed  Google Scholar 

  33. Robbins, A.B., Doran, J.E., Reese, A.C., Mansberger, A.R.: Cold-insoluble globulin levels in operative trauma: Serum depletion, wound sequestration and biological activity. Am. Surg. 46: 663, 1980.

    CAS  PubMed  Google Scholar 

  34. Rogers, B.E.: Host mechanisms which act to remove bacteria from the bloodstream. Bart. Rev. 24: 50, 1960.

    CAS  Google Scholar 

  35. Saba, T.M.: Physiology and pathophysiology of the reticuloendothelial system. Arch. Intern. Med. 126: 1031, 1970.

    Article  CAS  PubMed  Google Scholar 

  36. Saba, T.M.: Aspecific Opsonins. In: Proc. of 4th Internat. Convocation on immunology. In: Immune System and Infectious Diseases. S. Karger Co., Basel, 1975, p. 489.

    Google Scholar 

  37. Saba, T.M., Antikatzides, T.G.: Humoral mediated macrophage response during tumor growth. Brit. J. Cancer 21: 471, 1975.

    Article  Google Scholar 

  38. Saba, T.M., Albert, W.H., Blumenstock, F.A., Evanega, G., Staehler, F., Cho, F.: Evaluation of a rapid immunoturbidimetric assay for opsonic fibronectin in surgical and trauma patients administered cryoprecipitate. J. Lab. Clin. Med. 90: 473, 1981.

    Google Scholar 

  39. Saba, T.M., Blumenstock, F.A., Scovill, W.A., Bernard, H.R.: Cryoprecipitate reversal of opsonic alpha-2-surface binding glycoprotein deficiency in septic surgical and trauma patients. Science 201:622., 1977.

    Article  Google Scholar 

  40. Saba, T.M., Blumenstock, F.A., Weber, P., Kaplan, J.E.: Physiologic role for cold-insoluble globulin in systemic host defense: Implications of its characterization as the opsonic R2SB glycoprotein. Ann. N.Y. Acad. Sci. 312: 43, 1978.

    Article  CAS  PubMed  Google Scholar 

  41. Saba, T.M., Di Luzio, N.R.: Kupffer cell phagocytosis and metabolism of a variety of particles as a function of opsonization. J. Reticuloendothelial Soc. 2: 437, 1965.

    CAS  Google Scholar 

  42. Saba, T.M., Di Luzi_o, N.R.: Reticuloendothelial blockade and recovery as a function of opsonic activity. Am. J. Physiol. 216: 197, 1969.

    CAS  PubMed  Google Scholar 

  43. Saba, T.M., Jaffe, E.: Plasma fibronectin (opsonic glycoprotein): Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am. J. Med. 68: 577, 1980.

    Article  CAS  PubMed  Google Scholar 

  44. Scovill, W.A., Saba, T.M., Blumenstock, F.A., Bernard, H., Powers, S.R.: Opsonic alpha-2-surface binding glycoprotein therapy during sepsis. Ann. Surg. 188: 521, 1978.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Scovill, W.A., Saba, T.M., Kaplan, J.E., Bernard, H.R., Powers, S.R.: Disturbances in circulating opsonic activity in man after operative and blunt trauma. J. Surg. Res. 22: 709, 1977.

    Article  CAS  PubMed  Google Scholar 

  46. Snyder, E.L., Mosher, D.F., Hezzey, A., Golenwski, G.: Effect of blood transfusion on in vivo levels of plasma fibronectin. J. Lab. Clin. Med. 98: 336, 1981.

    CAS  PubMed  Google Scholar 

  47. Stathakis, N.E., Fountas, A., Tsianos, E.: Plasma fibronectin in normal subjects and in various disease states. J. Clin. Pathol. 34: 504, 1981.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Stossel, T.P.: Phagocytosis. New Engl. J. Med. 290: 717, 1974.

    CAS  Google Scholar 

  49. Yamada, K.M., Kennedy, D.W.: Fibroblast cellular and plasma fibronectin are similar but not identical. J. Cell. Biol. 80: 492, 1979

    Article  CAS  PubMed  Google Scholar 

  50. Yamada, K.M., Olden, K.: Fibronectin: Adhesive glycoproteins of cell surface and blood. Nature 275: 179, 1978.

    Article  CAS  PubMed  Google Scholar 

  51. Zweifach, B.W. Benacerraf, B., Thomas, L.: Relationship between the vascular manifestation of shock produced by endotoxin, trauma and hemorrhage. II. The possible role of the RES in resistance to each type of shock. J. Exp. Med. 106: 403, 1957.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Authors
  1. F. A. Blumenstock
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. M. Saba
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Kaplan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Red Cross Bloodbank Groningen-Drenthe, Groningen, The Netherlands

    P. C. Das

  2. Central Laboratory of the Dutch, Red Cross, Amsterdam, The Netherlands

    J. J. van Loghem (Professor of Immunology) (Professor of Immunology)

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Martinus Nijhoff Publishers, The Hague

About this chapter

Cite this chapter

Blumenstock, F.A., Saba, T.M., Kaplan, J.E. (1982). Plasma Fibronectin: Biochemical Properties and Clinical Relevance. In: Smit Sibinga, C.T., Das, P.C., van Loghem, J.J. (eds) Bloodtransfusion and Problems of Bleeding. Developments in Hematology and Immunology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7692-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-7692-4_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7694-8

  • Online ISBN: 978-94-009-7692-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation