Structural Elements of the Mammalian Sperm Nucleus
During spermiogenesis the spherical nucleus of the germ cell condenses and assumes a configuration that is distinct for each mammalian species. This nuclear transformation, whether yielding a falciform, spatulate or discoid shape, serves to protect the haploid genome and to facilitate penetration of the ovum by the motile sperm cell. Remodeling of the nucleus is complex. The process involves the removal of histones, the selective elimination of most nonhistone chromosomal proteins, the deposition of protamines, and the insertion of novel nuclear proteins (Bellvé, 1979; Bellvé & O’Brien, 1982). A microtubular array, the manchette, exists transiently in association with the condensing nucleus, acting as an external scaffold rather than imposing a direct mechanical force (Myles & Hepler, 1982). Consequently, sperm nuclear shape may be defined intrinsically by nuclear proteins, as suggested previously by Fawcett et al. (1971).
KeywordsAgar Heparin Polypeptide Arginine Hydrochloride
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- 2.Bellvé AR. 1979. In: Finn CA, ed. Oxford Reviews of Reproductive Biology, pp. 159–261. Oxford, Oxford University Press.Google Scholar
- 3.Bellvé AR. 1982, in press. In: Amann RP, Seidel GE Jr, eds. Prospects for Sexing Mammalian Sperm. Boulder, Colorado Assoc. University Press.Google Scholar
- 5.Bellvé AR, O’Brien DA. 1982, in press. In: Hartman JF, ed. Mechanisms and Control of Fertilization. New York, Academic Press, Inc.Google Scholar
- 11.Lalli M, Clermont Y. 1981. Am J Arat. 160: 419–434.Google Scholar